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p-S463,S465-SMAD5 [cytosol]
Stable Identifier
R-HSA-201473
Type
Protein [EntityWithAccessionedSequence]
Species
Homo sapiens
Compartment
cytosol
Synonyms
Phospho-R-SMAD5, Mothers against decapentaplegic homolog 5, SMA5_HUMAN
Icon
Locations in the PathwayBrowser
Expand all
Signal Transduction (Homo sapiens)
Signaling by TGFB family members (Homo sapiens)
Signaling by BMP (Homo sapiens)
Activated type I receptor phosphorylates R-Smad1/5/8 directly (Homo sapiens)
BMP:p-BMPR:Endofin:p-2S-SMAD1/5/8 [early endosome membrane] (Homo sapiens)
p-2S-SMAD1/5/8 [cytosol] (Homo sapiens)
p-S463,S465-SMAD5 [cytosol] (Homo sapiens)
I-Smad competes with Co-Smad for R-Smad1/5/8 (Homo sapiens)
I-SMAD:p-2S-SMAD1/5/8 [cytosol] (Homo sapiens)
p-2S-SMAD1/5/8 [cytosol] (Homo sapiens)
p-S463,S465-SMAD5 [cytosol] (Homo sapiens)
p-2S-SMAD1/5/8 [cytosol] (Homo sapiens)
p-S463,S465-SMAD5 [cytosol] (Homo sapiens)
Phospho-R-Smad1/5/8 dissociates from the receptor complex (Homo sapiens)
BMP:p-BMPR:Endofin:p-2S-SMAD1/5/8 [early endosome membrane] (Homo sapiens)
p-2S-SMAD1/5/8 [cytosol] (Homo sapiens)
p-S463,S465-SMAD5 [cytosol] (Homo sapiens)
p-2S-SMAD1/5/8 [cytosol] (Homo sapiens)
p-S463,S465-SMAD5 [cytosol] (Homo sapiens)
Phospho-R-Smad1/5/8 forms a complex with Co-Smad (Homo sapiens)
p-2S-SMAD1/5/8 [cytosol] (Homo sapiens)
p-S463,S465-SMAD5 [cytosol] (Homo sapiens)
p-2S-SMAD1/5/8:SMAD4 [cytosol] (Homo sapiens)
p-2S-SMAD1/5/8 [cytosol] (Homo sapiens)
p-S463,S465-SMAD5 [cytosol] (Homo sapiens)
The phospho-R-Smad1/5/8:Co-Smad transfers to the nucleus (Homo sapiens)
p-2S-SMAD1/5/8:SMAD4 [cytosol] (Homo sapiens)
p-2S-SMAD1/5/8 [cytosol] (Homo sapiens)
p-S463,S465-SMAD5 [cytosol] (Homo sapiens)
External Reference Information
External Reference
UniProt:Q99717 SMAD5
Gene Names
SMAD5, MADH5
Chain
initiator methionine:, chain:2-465
Reference Genes
BioGPS Gene:4090 SMAD5
COSMIC (genes):SMAD5 SMAD5
CTD Gene:4090 SMAD5
dbSNP Gene:4090 SMAD5
ENSEMBL:ENSG00000113658 SMAD5
ENSEMBL_homo_sapiens_GENE:ENSG00000113658.18 SMAD5
HGNC:6771 SMAD5
KEGG Gene (Homo sapiens):4090 SMAD5
Monarch:4090 SMAD5
NCBI Gene:4090 SMAD5
OMIM:603110 SMAD5
UCSC:Q99717 SMAD5
Reference Transcript
RefSeq:NM_005903.6 SMAD5
RefSeq:NM_001001420.2 SMAD5
RefSeq:NM_001001419.2 SMAD5
RefSeq:XM_017009470.1 SMAD5
Other Identifiers
1013_at
11729717_a_at
11729718_s_at
11729719_a_at
11741023_a_at
11757679_s_at
16989534
1952_s_at
205187_PM_at
205187_at
205188_PM_s_at
205188_s_at
225219_PM_at
225219_at
225223_PM_at
225223_at
235451_PM_at
235451_at
2830018
2830019
2830020
2830021
2830022
2830023
2830024
2830027
2830029
2830030
2830031
2830032
2830037
2830039
2830041
2830043
2830046
2830047
2830048
2830049
2830050
39926_at
4090
54698_at
8108238
84185_r_at
A_14_P106211
A_14_P121517
A_14_P123776
A_14_P137757
A_19_P00804893
A_23_P144944
A_33_P3220445
GE55680
GE79186
GO:0000122
GO:0000785
GO:0000977
GO:0000978
GO:0000981
GO:0001227
GO:0001503
GO:0001649
GO:0001657
GO:0001880
GO:0002051
GO:0002376
GO:0003012
GO:0003013
GO:0003161
GO:0003677
GO:0003700
GO:0005515
GO:0005634
GO:0005654
GO:0005667
GO:0005694
GO:0005737
GO:0005739
GO:0005829
GO:0006351
GO:0006355
GO:0006357
GO:0007165
GO:0007179
GO:0007281
GO:0009653
GO:0009880
GO:0010629
GO:0012501
GO:0017151
GO:0022414
GO:0023052
GO:0030154
GO:0030218
GO:0030509
GO:0031625
GO:0032991
GO:0043066
GO:0043226
GO:0045669
GO:0045893
GO:0045944
GO:0046872
GO:0048856
GO:0051216
GO:0060048
GO:0060348
GO:0060395
GO:0070411
GO:0071141
GO:0071144
GO:0071407
GO:0140110
GO:1902045
GO:1990837
HMNXSV003024162
Hs.165210.0.A1_3p_at
Hs.167700.0.S1_3p_at
Hs.167700.0.S2_3p_at
ILMN_1674551
ILMN_2371984
PH_hs_0022793
TC05000683.hg
TC05002640.hg
U59913_at
g2317785_3p_at
g5174514_3p_a_at
Participates
as a member of
p-2S-SMAD1/5/8 [cytosol] (Homo sapiens)
Other forms of this molecule
SMAD5 [cytosol]
p-S463,S465-SMAD5 [nucleoplasm]
Inferred To
phospho-SMAD5 [cytosol]
(Bos taurus)
phospho-SMAD5 [cytosol]
(Canis familiaris)
phospho-SMAD5 [cytosol]
(Sus scrofa)
phospho-p-S463,S465-SMAD5 [cytosol]
(Caenorhabditis elegans)
phospho-p-S463,S465-SMAD5 [cytosol]
(Danio rerio)
phospho-p-S463,S465-SMAD5 [cytosol]
(Drosophila melanogaster)
phospho-p-S463,S465-SMAD5 [cytosol]
(Gallus gallus)
phospho-p-S463,S465-SMAD5 [cytosol]
(Mus musculus)
phospho-p-S463,S465-SMAD5 [cytosol]
(Rattus norvegicus)
Modified Residues
Name
O-phospho-L-serine at 463
Coordinate
463
PsiMod Name
O-phospho-L-serine [MOD:00046]
PsiMod Definition
A protein modification that effectively converts an L-serine residue to O-phospho-L-serine.
Name
O-phospho-L-serine at 465
Coordinate
465
PsiMod Name
O-phospho-L-serine [MOD:00046]
PsiMod Definition
A protein modification that effectively converts an L-serine residue to O-phospho-L-serine.
Cross References
RefSeq
NP_001001419.1
,
NP_005894.3
,
NP_001001420.1
,
XP_016864959.1
OpenTargets
ENSG00000113658
GeneCards
Q99717
HPA
ENSG00000113658-SMAD5
Ensembl
ENST00000545279
,
ENST00000545620
,
ENSP00000441954
,
ENST00000509297
,
ENSP00000426696
,
ENSP00000446474
,
ENSG00000113658
PRO
Q99717
Pharos - Targets
Q99717
PDB
6TCE
,
6FZS
Interactors (3)
Accession
#Entities
Entities
Confidence Score
Evidence (IntAct)
UniProt:Q9HAU4 SMURF2
2
SMURF2 [nucleoplasm]
(R-HSA-178202)
SMURF2 [cytosol]
(R-HSA-173537)
0.659
3
UniProt:P17844 DDX5
4
DDX5 [nucleoplasm]
(R-HSA-3900136)
DDX5 [cytosol]
(R-HSA-9682643)
polySUMO2-K53-DDX5 [nucleoplasm]
(R-HSA-3900186)
monoSUMO1-K53-DDX5 [nucleoplasm]
(R-HSA-3900041)
0.558
3
UniProt:Q9H8X2 IPPK
2
IPPK [cytosol]
(R-HSA-1604598)
IPPK [nucleoplasm]
(R-HSA-2023949)
0.527
2
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