Upon phosphorylation of the R-SMAD (SMAD2/3), the conformation of the C-terminal (MH2) domain of the R-SMAD changes, lowering its affinity for the type I receptor and ZFYVE9 (SARA). As a result, the phosphorylated R-SMAD dissociates from the activated receptor complex (TGFBR).
Massague, J, Kretzschmar, M, Doody, J, Liu, F, Hata, A
Massague, J, Lagna, G, Hemmati-Brivanlou, A, Hata, A
Cao, X, Chang, C, Nie, S, Wan, M, Shi, W, Xie, S
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