Ubiquitin-dependent degradation of the Smad complex terminates BMP2 signalling

Stable Identifier
R-HSA-201425
Type
Reaction [omitted]
Species
Homo sapiens
Compartment
nucleoplasm
ReviewStatus
5/5
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Ubiquitin-dependent degradation of the Smad complex terminates BMP2 signalling
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The nuclear R-SMAD:Co-SMAD complex recruits ubiquitin conjugating enzymes, such as UBE2D1 and UBE2D3, that ubiquitinate the complex and eventually lead to its proteasomal degradation. This provides an end point to the signaling pathway.
Literature References
PubMed ID Title Journal Year
10587654 SMAD destruction turns off signalling

Heldin, CH, ten Dijke, P

Nat Cell Biol 1999
11571290 Proteasomal degradation of Smad1 induced by bone morphogenetic proteins

Gruendler, C, Lin, Y, Farley, J, Wang, T

J Biol Chem 2001
Participants
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as an event of
Event Information
Go Biological Process
negative regulation of BMP signaling pathway (0030514)
Catalyst Activity

ubiquitin-protein transferase activity of Nuclear ubiquitin ligase [nucleoplasm]

Physical Entity
Nuclear ubiquitin ligase [nucleoplasm] (Homo sapiens)
Activity
ubiquitin-protein transferase activity (GO:0004842)
Orthologous Events
Ubiquitin-dependent degradation of the Smad complex terminates BMP2 signalling (Bos taurus)
Ubiquitin-dependent degradation of the Smad complex terminates BMP2 signalling (Caenorhabditis elegans)
Ubiquitin-dependent degradation of the Smad complex terminates BMP2 signalling (Canis familiaris)
Ubiquitin-dependent degradation of the Smad complex terminates BMP2 signalling (Drosophila melanogaster)
Ubiquitin-dependent degradation of the Smad complex terminates BMP2 signalling (Gallus gallus)
Ubiquitin-dependent degradation of the Smad complex terminates BMP2 signalling (Mus musculus)
Ubiquitin-dependent degradation of the Smad complex terminates BMP2 signalling (Rattus norvegicus)
Ubiquitin-dependent degradation of the Smad complex terminates BMP2 signalling (Sus scrofa)
Authored
Huminiecki, L  (2007-11-07)
Moustakas, A  (2007-11-07)
Reviewed
Heldin, CH  (2007-11-12)
Created
Jassal, B  (2007-08-13)
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