Toggle navigation
About
What is Reactome ?
News
Team
Scientific Advisory Board
Editorial Calendar
Statistics
Our Logo
License Agreement
Privacy Notice
Disclaimer
Content
Table of Contents
DOIs
Data Schema
ORCID Integration Project
COVID-19 Disease Pathways
Docs
Userguide
Pathway Browser
How do I search ?
Details Panel
Analysis Tools
Analysis Data
Analysis Gene Expression
Species Comparison
Tissue Distribution
Diseases
ReactomeFIViz
Developer's Zone
Graph Database
Analysis Service
Content Service
Pathways Overview
Pathway Diagrams
Icon Info
EHLD Specs & Guidelines
Icon Library Guidelines
Data Model
Computationally inferred events
Linking to Us
Citing us
Tools
Pathway Browser
Analysis Data
Analysis Gene Expression
Species Comparison
Tissue Distribution
Analysis Service
Content Service
ReactomeFIViz
Overlays
DisGeNET
Web
API
Advanced Data Search
Site Search
Community
Icon Library
Outreach
Events
Training
Publications
Partners
Papers Citing Us
Resources Guide
Collaboration
Download
About
What is Reactome ?
News
Team
Scientific Advisory Board
Editorial Calendar
Statistics
Our Logo
License Agreement
Privacy Notice
Disclaimer
Content
Table of Contents
DOIs
Data Schema
ORCID Integration Project
COVID-19 Disease Pathways
Docs
Userguide
Pathway Browser
How do I search ?
Details Panel
Analysis Tools
Analysis Data
Analysis Gene Expression
Species Comparison
Tissue Distribution
Diseases
ReactomeFIViz
Developer's Zone
Graph Database
Analysis Service
Content Service
Pathways Overview
Pathway Diagrams
Icon Info
EHLD Specs & Guidelines
Icon Library Guidelines
Data Model
Computationally inferred events
Linking to Us
Citing us
Tools
Pathway Browser
Analysis Data
Analysis Gene Expression
Species Comparison
Tissue Distribution
Analysis Service
Content Service
ReactomeFIViz
Overlays
DisGeNET
Web
API
Advanced Data Search
Site Search
Community
Icon Library
Outreach
Events
Training
Publications
Partners
Papers Citing Us
Resources Guide
Collaboration
Download
Search ...
Go!
A2M [cytosol]
Stable Identifier
R-HSA-200618
Type
Protein [EntityWithAccessionedSequence]
Species
Homo sapiens
Compartment
cytosol
Locations in the PathwayBrowser
Expand all
Signal Transduction (Homo sapiens)
Signaling by Rho GTPases (Homo sapiens)
Rho GTPase cycle (Homo sapiens)
GAPs inactivate Rho GTPase:GTP by hydrolysis (Homo sapiens)
GAPs [cytosol] (Homo sapiens)
A2M [cytosol] (Homo sapiens)
External Reference Information
External Reference
UniProt:P01023 A2M
Gene Names
A2M, CPAMD5, FWP007
Chain
signal peptide:1-23, chain:24-1474
Reference Genes
BioGPS Gene:2 A2M
COSMIC (genes):A2M A2M
CTD Gene:2 A2M
dbSNP Gene:2 A2M
ENSEMBL:ENSG00000175899 A2M
HGNC:7 A2M
KEGG Gene (Homo sapiens):2 A2M
Monarch:2 A2M
NCBI Gene:2 A2M
OMIM:103950 A2M
UCSC:P01023 A2M
Reference Transcript
RefSeq:NM_001347425.1 A2M
RefSeq:NM_001347423.1 A2M
RefSeq:NM_000014.5 A2M
RefSeq:NM_001347424.1 A2M
Other Identifiers
11715363_a_at
16761012
2
217757_at
3443351
3443352
3443353
3443355
3443356
3443358
3443362
3443366
3443367
3443368
3443369
3443370
3443374
3443377
3443379
3443380
3443381
3443383
3443385
3443386
3443387
3443388
3443390
3443392
3443393
3443395
3443396
3443397
3443400
3443402
3443403
3443405
3443406
3443407
3443409
3443410
3443411
3443412
3443413
3443415
3443416
3443419
3443422
3443424
3443425
3443426
3443431
3443432
3443433
74536_i_at
74537_f_at
75187_f_at
7960947
A_23_P116898
GE57808
GO:0001869
GO:0002020
GO:0002376
GO:0002576
GO:0003674
GO:0004866
GO:0004867
GO:0005102
GO:0005515
GO:0005575
GO:0005576
GO:0005615
GO:0005622
GO:0005737
GO:0005829
GO:0006810
GO:0006950
GO:0007165
GO:0007597
GO:0008150
GO:0010466
GO:0010951
GO:0016192
GO:0019838
GO:0019899
GO:0019959
GO:0019966
GO:0022617
GO:0030154
GO:0030198
GO:0030234
GO:0030414
GO:0031012
GO:0031093
GO:0031410
GO:0043120
GO:0043226
GO:0048306
GO:0048863
GO:0051056
GO:0062023
GO:0070062
GO:0072562
ILMN_1745607
M11313_s_at
PH_hs_0041025
TC12001187.hg
Participant Of
hasMember
GAPs [cytosol]
Other forms of this molecule
A2M [platelet alpha granule lumen]
A2M [extracellular region]
Inferred To
tep-1 [cytosol] (Caenorhabditis elegans)
a2m [cytosol] (Xenopus tropicalis)
a2ml [cytosol] (Danio rerio)
A2m [cytosol] (Mus musculus)
A2m [cytosol] (Rattus norvegicus)
LOC477699 [cytosol] (Canis familiaris)
A2M [cytosol] (Gallus gallus)
A2M [cytosol] (Sus scrofa)
Tep2 [cytosol] (Drosophila melanogaster)
Cross References
RefSeq
NP_001334353.1
,
NP_000005.2
,
NP_001334354.1
,
NP_001334352.1
OpenTargets
ENSG00000175899
GeneCards
P01023
HPA
ENSG00000175899-A2M
Ensembl
ENSG00000175899
,
ENSP00000323929
,
ENST00000318602
PRO
P01023
Orphanet
26464
HMDB Protein
HMDBP02061
PDB
1BV8
,
4ACQ
,
2P9R
Interactors (11)
Accession
#Entities
Entities
Confidence Score
Evidence (IntAct)
UniProt:P07948 LYN
5
LYN [cytosol]
(R-HSA-354251)
LYN [plasma membrane]
(R-HSA-197943)
p-Y396-LYN [plasma membrane]
(R-HSA-2454229)
MyrG2-PalmC3-LYN [plasma membrane]
(R-HSA-9606875)
p-Y397-LYN [cytosol]
(R-HSA-8942608)
0.556
3
UniProt:P09017 HOXC4
1
HOXC4 [nucleoplasm]
(R-HSA-5617871)
0.556
3
UniProt:Q92993 KAT5
1
KAT5 [nucleoplasm]
(R-HSA-3321979)
0.556
3
UniProt:Q9UNE7 STUB1
1
STUB1 [cytosol]
(R-HSA-975970)
0.556
3
UniProt:P35222 CTNNB1
33
CTNNB1 S45F [cytosol]
(R-HSA-4791268)
CTNNB1 S45A [cytosol]
(R-HSA-9663982)
CTNNB1 S45C [cytosol]
(R-HSA-9663983)
CTNNB1 S45Y [cytosol]
(R-HSA-9663975)
CTNNB1 S45N [cytosol]
(R-HSA-9663984)
CTNNB1 S45P [cytosol]
(R-HSA-4791272)
pT41,S45-CTNNB1 S37P [cytosol]
(R-HSA-9663981)
pT41,S45-CTNNB1 S37F [cytosol]
(R-HSA-4839621)
pT41,S45-CTNNB1 S37A [cytosol]
(R-HSA-4839619)
pT41,S45-CTNNB1 S37Y [cytosol]
(R-HSA-9663978)
pT41,S45-CTNNB1 S37C [cytosol]
(R-HSA-4839617)
pS37,T41,S45-CTNNB1 S33A [cytosol]
(R-HSA-9663976)
pS37,T41,S45-CTNNB1 S33T [cytosol]
(R-HSA-9663977)
pS37,T41,S45-CTNNB1 S33C [cytosol]
(R-HSA-4839630)
pS37,T41,S45-CTNNB1 S33F [cytosol]
(R-HSA-4839628)
pS37,T41,S45-CTNNB1 S33P [cytosol]
(R-HSA-4839626)
pS37,T41,S45-CTNNB1 S33Y [cytosol]
(R-HSA-4839625)
pS45-CTNNB1 T41N [cytosol]
(R-HSA-9663980)
pS45-CTNNB1 T41A [cytosol]
(R-HSA-4836868)
pS45-CTNNB1 T41I [cytosol]
(R-HSA-4839612)
Ub-K,p-Y-CTNNB1 [cytosol]
(R-HSA-8877006)
p-Y-CTNNB1 [cytosol]
(R-HSA-8876940)
p-S552-CTNNB1 [nucleoplasm]
(R-HSA-3134926)
p-S552-CTNNB1 [cytosol]
(R-HSA-3134933)
CTNNB1(116-376) [cytosol]
(R-HSA-202950)
CTNNB1(1-115) [cytosol]
(R-HSA-202930)
CTNNB1 [plasma membrane]
(R-HSA-9038440)
p-S45 CTNNB1 [cytosol]
(R-HSA-8942363)
p-T41,S45 CTNNB1 [cytosol]
(R-HSA-8942367)
p-S37,T41,S45, CTNNB1 [cytosol]
(R-HSA-8942369)
p-S33,S37,T41,S45 CTNNB1 [cytosol]
(R-HSA-8942374)
CTNNB1 [cytosol]
(R-HSA-448839)
CTNNB1 [nucleoplasm]
(R-HSA-3451168)
0.556
3
UniProt:O75925 PIAS1
1
PIAS1 [nucleoplasm]
(R-HSA-877307)
0.556
3
UniProt:Q9ULV1 FZD4
4
ub-FZD4 [plasma membrane]
(R-HSA-4641182)
FZD4 [clathrin-coated endocytic vesicle membrane]
(R-HSA-8869088)
FZD4 [clathrin-coated endocytic vesicle membrane]
(R-HSA-5138457)
FZD4 [plasma membrane]
(R-HSA-443956)
0.556
3
UniProt:P10599 TXN
4
TXN [nucleoplasm]
(R-HSA-9617732)
2xHC-TXN [nucleoplasm]
(R-HSA-9617733)
2xHC-TXN [cytosol]
(R-HSA-73668)
TXN [cytosol]
(R-HSA-66000)
0.556
3
UniProt:Q99497 PARK7
7
PARK7 [nucleoplasm]
(R-HSA-3900141)
SUMO1-K130-PARK7 [nucleoplasm]
(R-HSA-4085351)
PolyUb-Misfolded PARK7 [late endosome lumen]
(R-HSA-9660005)
Misfolded PARK7 [cytosol]
(R-HSA-9641100)
Ub-Misfolded PARK7 [cytosol]
(R-HSA-9641123)
PolyUb-Misfolded PARK7 [cytosol]
(R-HSA-9641128)
PolyUb-Misfolded PARK7 [lysosomal lumen]
(R-HSA-9659997)
0.556
3
UniProt:P04141 CSF2
1
CSF2 [extracellular region]
(R-HSA-517562)
0.556
3
UniProt:P04271 S100B
1
S100B [extracellular region]
(R-HSA-879433)
0.556
3
© 2021
Reactome
Cite Us!
Cite Us!
Cite Us!
Warning!
Unable to extract citation. Please try again later.
Download As:
BibTeX
RIS
Text