Reactome | A2M [cytosol]

A2M [cytosol]

Stable Identifier

R-HSA-200618

Type

Protein [EntityWithAccessionedSequence]

Species

Homo sapiens

Compartment

cytosol

Locations in the PathwayBrowser

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External Reference Information

External Reference

UniProt:P01023 A2M

Gene Names

A2M, CPAMD5, FWP007

Chain

signal peptide:1-23, chain:24-1474

Reference Genes

BioGPS Gene:2 A2M

COSMIC (genes):A2M A2M

CTD Gene:2 A2M

dbSNP Gene:2 A2M

ENSEMBL:ENSG00000175899 A2M

HGNC:7 A2M

KEGG Gene (Homo sapiens):2 A2M

Monarch:2 A2M

NCBI Gene:2 A2M

OMIM:103950 A2M

UCSC:P01023 A2M

Reference Transcript

Other Identifiers

11715363_a_at

16761012

217757_at

3443351

3443352

3443353

3443355

3443356

3443358

3443362

3443366

3443367

3443368

3443369

3443370

3443374

3443377

3443379

3443380

3443381

3443383

3443385

3443386

3443387

3443388

3443390

3443392

3443393

3443395

3443396

3443397

3443400

3443402

3443403

3443405

3443406

3443407

3443409

3443410

3443411

3443412

3443413

3443415

3443416

3443419

3443422

3443424

3443425

3443426

3443431

3443432

3443433

74536_i_at

74537_f_at

75187_f_at

7960947

A_23_P116898

GE57808

GO:0001869

GO:0002020

GO:0002376

GO:0002576

GO:0003674

GO:0004866

GO:0004867

GO:0005102

GO:0005515

GO:0005575

GO:0005576

GO:0005615

GO:0005622

GO:0005737

GO:0005829

GO:0006810

GO:0006950

GO:0007165

GO:0007597

GO:0008150

GO:0010466

GO:0010951

GO:0016192

GO:0019838

GO:0019899

GO:0019959

GO:0019966

GO:0022617

GO:0030154

GO:0030198

GO:0030234

GO:0030414

GO:0031012

GO:0031093

GO:0031410

GO:0043120

GO:0043226

GO:0048306

GO:0048863

GO:0051056

GO:0062023

GO:0070062

GO:0072562

ILMN_1745607

M11313_s_at

PH_hs_0041025

TC12001187.hg

Participant Of

hasMember

GAPs [cytosol]

Other forms of this molecule

A2M [platelet alpha granule lumen]

A2M [extracellular region]

Inferred To

tep-1 [cytosol] (Caenorhabditis elegans)

a2m [cytosol] (Xenopus tropicalis)

a2ml [cytosol] (Danio rerio)

A2m [cytosol] (Mus musculus)

A2m [cytosol] (Rattus norvegicus)

LOC477699 [cytosol] (Canis familiaris)

A2M [cytosol] (Gallus gallus)

A2M [cytosol] (Sus scrofa)

Tep2 [cytosol] (Drosophila melanogaster)

Cross References

RefSeq

NP_001334353.1, NP_000005.2, NP_001334354.1, NP_001334352.1

OpenTargets

ENSG00000175899

GeneCards

P01023

HPA

ENSG00000175899-A2M

Ensembl

ENSG00000175899, ENSP00000323929, ENST00000318602

PRO

P01023

Orphanet

26464

HMDB Protein

HMDBP02061

PDB

1BV8, 4ACQ, 2P9R

Interactors (11)

Accession	#Entities	Entities	Confidence Score	Evidence (IntAct)
UniProt:P07948 LYN	5	LYN [cytosol] (R-HSA-354251) LYN [plasma membrane] (R-HSA-197943) p-Y396-LYN [plasma membrane] (R-HSA-2454229) MyrG2-PalmC3-LYN [plasma membrane] (R-HSA-9606875) p-Y397-LYN [cytosol] (R-HSA-8942608)	0.556	3
UniProt:P09017 HOXC4	1	HOXC4 [nucleoplasm] (R-HSA-5617871)	0.556	3
UniProt:Q92993 KAT5	1	KAT5 [nucleoplasm] (R-HSA-3321979)	0.556	3
UniProt:Q9UNE7 STUB1	1	STUB1 [cytosol] (R-HSA-975970)	0.556	3
UniProt:P35222 CTNNB1	33	CTNNB1 S45F [cytosol] (R-HSA-4791268) CTNNB1 S45A [cytosol] (R-HSA-9663982) CTNNB1 S45C [cytosol] (R-HSA-9663983) CTNNB1 S45Y [cytosol] (R-HSA-9663975) CTNNB1 S45N [cytosol] (R-HSA-9663984) CTNNB1 S45P [cytosol] (R-HSA-4791272) pT41,S45-CTNNB1 S37P [cytosol] (R-HSA-9663981) pT41,S45-CTNNB1 S37F [cytosol] (R-HSA-4839621) pT41,S45-CTNNB1 S37A [cytosol] (R-HSA-4839619) pT41,S45-CTNNB1 S37Y [cytosol] (R-HSA-9663978) pT41,S45-CTNNB1 S37C [cytosol] (R-HSA-4839617) pS37,T41,S45-CTNNB1 S33A [cytosol] (R-HSA-9663976) pS37,T41,S45-CTNNB1 S33T [cytosol] (R-HSA-9663977) pS37,T41,S45-CTNNB1 S33C [cytosol] (R-HSA-4839630) pS37,T41,S45-CTNNB1 S33F [cytosol] (R-HSA-4839628) pS37,T41,S45-CTNNB1 S33P [cytosol] (R-HSA-4839626) pS37,T41,S45-CTNNB1 S33Y [cytosol] (R-HSA-4839625) pS45-CTNNB1 T41N [cytosol] (R-HSA-9663980) pS45-CTNNB1 T41A [cytosol] (R-HSA-4836868) pS45-CTNNB1 T41I [cytosol] (R-HSA-4839612) Ub-K,p-Y-CTNNB1 [cytosol] (R-HSA-8877006) p-Y-CTNNB1 [cytosol] (R-HSA-8876940) p-S552-CTNNB1 [nucleoplasm] (R-HSA-3134926) p-S552-CTNNB1 [cytosol] (R-HSA-3134933) CTNNB1(116-376) [cytosol] (R-HSA-202950) CTNNB1(1-115) [cytosol] (R-HSA-202930) CTNNB1 [plasma membrane] (R-HSA-9038440) p-S45 CTNNB1 [cytosol] (R-HSA-8942363) p-T41,S45 CTNNB1 [cytosol] (R-HSA-8942367) p-S37,T41,S45, CTNNB1 [cytosol] (R-HSA-8942369) p-S33,S37,T41,S45 CTNNB1 [cytosol] (R-HSA-8942374) CTNNB1 [cytosol] (R-HSA-448839) CTNNB1 [nucleoplasm] (R-HSA-3451168)	0.556	3
UniProt:O75925 PIAS1	1	PIAS1 [nucleoplasm] (R-HSA-877307)	0.556	3
UniProt:Q9ULV1 FZD4	4	ub-FZD4 [plasma membrane] (R-HSA-4641182) FZD4 [clathrin-coated endocytic vesicle membrane] (R-HSA-8869088) FZD4 [clathrin-coated endocytic vesicle membrane] (R-HSA-5138457) FZD4 [plasma membrane] (R-HSA-443956)	0.556	3
UniProt:P10599 TXN	4	TXN [nucleoplasm] (R-HSA-9617732) 2xHC-TXN [nucleoplasm] (R-HSA-9617733) 2xHC-TXN [cytosol] (R-HSA-73668) TXN [cytosol] (R-HSA-66000)	0.556	3
UniProt:Q99497 PARK7	7	PARK7 [nucleoplasm] (R-HSA-3900141) SUMO1-K130-PARK7 [nucleoplasm] (R-HSA-4085351) PolyUb-Misfolded PARK7 [late endosome lumen] (R-HSA-9660005) Misfolded PARK7 [cytosol] (R-HSA-9641100) Ub-Misfolded PARK7 [cytosol] (R-HSA-9641123) PolyUb-Misfolded PARK7 [cytosol] (R-HSA-9641128) PolyUb-Misfolded PARK7 [lysosomal lumen] (R-HSA-9659997)	0.556	3
UniProt:P04141 CSF2	1	CSF2 [extracellular region] (R-HSA-517562)	0.556	3
UniProt:P04271 S100B	1	S100B [extracellular region] (R-HSA-879433)	0.556	3

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