Exchange of palmitoylcarnitine and carnitine across the inner mitochondrial membrane

Stable Identifier
R-HSA-200424
Type
Reaction [transition]
Species
Homo sapiens
Compartment
mitochondrial intermembrane space, mitochondrial inner membrane, mitochondrial matrix
Synonyms
(R)-carnitine(out) + O-hexadecanoyl-(R)-carnitine(in) = (R)-carnitine(in) + O-hexadecanoyl-(R)-carnitine(out)
ReviewStatus
5/5
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Exchange of palmitoylcarnitine and carnitine across the inner mitochondrial membrane
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The carnitine-acylcarnitine transporter (SLC25A20 / CACT), embedded in the inner mitochondrial membrane, mediates the exchange of palmitoyl-carnitine (and other acylcarnitine esters) and carnitine across the inner mitochondrial membrane (Huizing et al., 1997).
Literature References
PubMed ID Title Journal Year
9399886 Cloning of the human carnitine-acylcarnitine carrier cDNA and identification of the molecular defect in a patient

Huizing, M, Iacobazzi, V, IJlst, L, Savelkoul, P, Ruitenbeek, W, van den Heuvel, L, Indiveri, C, Smeitink, J, Trijbels, F, Wanders, RJA, Palmieri, F

Am J Hum Genet 1997
Participants
Input
Output
Participates
as an event of
Catalyst Activity

carnitine:O-acyl-L-carnitine antiporter activity of SLC25A20 [mitochondrial inner membrane]

Physical Entity
SLC25A20 [mitochondrial inner membrane] (Homo sapiens)
Activity
carnitine:O-acyl-L-carnitine antiporter activity (GO:0005476)
Orthologous Events
Exchange of palmitoylcarnitine and carnitine across the inner mitochondrial membrane (Bos taurus)
Exchange of palmitoylcarnitine and carnitine across the inner mitochondrial membrane (Caenorhabditis elegans)
Exchange of palmitoylcarnitine and carnitine across the inner mitochondrial membrane (Canis familiaris)
Exchange of palmitoylcarnitine and carnitine across the inner mitochondrial membrane (Danio rerio)
Exchange of palmitoylcarnitine and carnitine across the inner mitochondrial membrane (Drosophila melanogaster)
Exchange of palmitoylcarnitine and carnitine across the inner mitochondrial membrane (Gallus gallus)
Exchange of palmitoylcarnitine and carnitine across the inner mitochondrial membrane (Mus musculus)
Exchange of palmitoylcarnitine and carnitine across the inner mitochondrial membrane (Rattus norvegicus)
Exchange of palmitoylcarnitine and carnitine across the inner mitochondrial membrane (Saccharomyces cerevisiae)
Exchange of palmitoylcarnitine and carnitine across the inner mitochondrial membrane (Schizosaccharomyces pombe)
Exchange of palmitoylcarnitine and carnitine across the inner mitochondrial membrane (Sus scrofa)
Exchange of palmitoylcarnitine and carnitine across the inner mitochondrial membrane (Xenopus tropicalis)
Cross References
RHEA
Rhea
Authored
Gopinathrao, G  (2007-07-30)
Reviewed
D'Eustachio, P  (2007-07-31)
Created
Gopinathrao, G  (2007-07-18)
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