Exchange of palmitoylcarnitine and carnitine across the inner mitochondrial membrane

Stable Identifier
R-HSA-200424
Type
Reaction [transition]
Species
Homo sapiens
Compartment
Synonyms
(R)-carnitine(out) + O-hexadecanoyl-(R)-carnitine(in) = (R)-carnitine(in) + O-hexadecanoyl-(R)-carnitine(out)
ReviewStatus
5/5
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The carnitine-acylcarnitine transporter (SLC25A20 / CACT), embedded in the inner mitochondrial membrane, mediates the exchange of palmitoyl-carnitine (and other acylcarnitine esters) and carnitine across the inner mitochondrial membrane (Huizing et al., 1997).
Literature References
PubMed ID Title Journal Year
9399886 Cloning of the human carnitine-acylcarnitine carrier cDNA and identification of the molecular defect in a patient

Indiveri, C, IJlst, L, Smeitink, J, Ruitenbeek, W, Savelkoul, P, Huizing, M, Palmieri, F, Wanders, RJA, Trijbels, F, van den Heuvel, L, Iacobazzi, V

Am J Hum Genet 1997
Participants
Participates
Catalyst Activity

carnitine:acyl carnitine antiporter activity of SLC25A20 [mitochondrial inner membrane]

Orthologous Events
Cross References
RHEA
Authored
Reviewed
Created
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