Reactome | Creatine transport across the plasma membrane

Creatine transport across the plasma membrane

Stable Identifier

R-HSA-200396

Type

Reaction [transition]

Species

Homo sapiens

Compartment

plasma membrane

ReviewStatus

5/5

Locations in the PathwayBrowser

Expand all

General

SBML | | PDF

SVG | | PPTX | SBGN

Creatine transport across the plasma membrane

Click the image above or here to open this reaction in the Pathway Browser
The layout of this reaction may differ from that in the pathway view due to the constraints in pathway layout

The SLC6A8 transport protein associated with the plasma membrane mediates the uptake of extracellular creatine and a sodium ion (Sora et al. 1994). Molecular and biochemical studies of patients deficient in SLC6A8 protein confirm this function in vivo (e.g., Salomons et al. 2003).

Literature References

PubMed ID	Title	Journal	Year
12889669	X-linked creatine transporter defect: an overview van Dooren, SJ, Verhoeven, NM, Schwartz, C, DeGrauw, TJ, Marsden, D, Salomons, GS, Cecil, KM, Jakobs, C	J Inherit Metab Dis	2003
7945388	The cloning and expression of a human creatine transporter Santoro, G, Roeske, WR, Horvath, R, Yamamura, HI, Sora, I, Richman, J, Wang, Y, Wei, H, Nguyen, M, Waite, S, Vanderah, T	Biochem Biophys Res Commun	1994