Reactome | creatine + ATP => phosphocreatine + ADP [CK octamer]

creatine + ATP => phosphocreatine + ADP [CK octamer]

Stable Identifier

R-HSA-200326

Type

Reaction [transition]

Species

Homo sapiens

Compartment

mitochondrial inner membrane, cytosol

ReviewStatus

5/5

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creatine + ATP => phosphocreatine + ADP [CK octamer]

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Creatine kinase octamers associated with the inner mitochondrial membrane catalyze the reaction of creatine and ATP to form phosphocreatine and ADP. Two mitochondrial creatine kinase proteins have been identified, one encoded by CKMT1A and B that is found in many tissues and one encoded by CKMT2 that is found in sarcomeres (Haas et al. 1988; Haas and Straus 1990). Studies of sarcomeric creatine kinase octamers suggest that their organization and association with phospholipids in the inner mitochondrial membrane may facilitate energy transfer from ATP generated in the mitochondrial matrix to cytosolic phosphocreatine (Khuchua et al. 1998; Schlattner et al. 2004).

Literature References

PubMed ID	Title	Journal	Year
2324105	Separate nuclear genes encode sarcomere-specific and ubiquitous human mitochondrial creatine kinase isoenzymes Haas, RC, Strauss, AW	J Biol Chem	1990
15044463	C-terminal lysines determine phospholipid interaction of sarcomeric mitochondrial creatine kinase Schlattner, U, Gehring, F, Vernoux, N, Tokarska-Schlattner, M, Neumann, D, Marcillat, O, Vial, C, Wallimann, T	J Biol Chem	2004
9722522	Octamer formation and coupling of cardiac sarcomeric mitochondrial creatine kinase are mediated by charged N-terminal residues Khuchua, ZA, Qin, W, Boero, J, Cheng, J, Payne, RM, Saks, VA, Strauss, AW	J Biol Chem	1998
2914937	Isolation and characterization of the gene and cDNA encoding human mitochondrial creatine kinase Haas, RC, Korenfeld, C, Zhang, Z, Perryman, B, Roman, D, Strauss, AW	J Biol Chem	1989