Reactome | creatine + ATP => phosphocreatine + ADP [CKB,CKM]

creatine + ATP => phosphocreatine + ADP [CKB,CKM]

Stable Identifier

R-HSA-200318

Type

Reaction [transition]

Species

Homo sapiens

Compartment

cytosol

ReviewStatus

5/5

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creatine + ATP => phosphocreatine + ADP [CKB,CKM]

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Cytosolic creatine kinase catalyzes the reaction of creatine and ATP to form phosphocreatine and ADP. The active form of the enzyme is a dimer. Monomers of the cytosolic enzyme occur in two isoforms, B and M, so called because of their abundance in brain and muscle respectively. The enzyme is widely expressed in the body and many tissues express both isoforms. Both homo- (BB, MM) and heterodimers (BM) are catalytically active.

Literature References

PubMed ID	Title	Journal	Year
16981706	Exploring the role of the active site cysteine in human muscle creatine kinase Flynn, AJ, Naor, MM, McLeish, MJ, Jensen, JH, Cui, G, Wang, PF, Merz KM, Jr, Kenyon, GL	Biochemistry	2006