Reactome | MEF2A [nucleoplasm]

MEF2A [nucleoplasm]

Stable Identifier

R-HSA-199903

Type

Protein [EntityWithAccessionedSequence]

Species

Homo sapiens

Compartment

nucleoplasm

Synonyms

Myocyte-specific enhancer factor 2A, MEFA_HUMAN

Locations in the PathwayBrowser

Expand all

Immune System (Homo sapiens)

- Cytokine Signaling in Immune system (Homo sapiens)
  - Signaling by Interleukins (Homo sapiens)
    - Interleukin-17 signaling (Homo sapiens)
      - MAP kinase activation (Homo sapiens)
        
        MAPK targets/ Nuclear events mediated by MAP kinases (Homo sapiens)
        
        ERK/MAPK targets (Homo sapiens)
        
        ERK5 activates the transcription factor MEF2 (Homo sapiens)
        
        MEF2 [nucleoplasm] (Homo sapiens)
        
        MEF2A [nucleoplasm] (Homo sapiens)
- Innate Immune System (Homo sapiens)
  - Toll-like Receptor Cascades (Homo sapiens)
    - Toll Like Receptor 10 (TLR10) Cascade (Homo sapiens)
      - MyD88 cascade initiated on plasma membrane (Homo sapiens)
        
        MAP kinase activation (Homo sapiens)
        
        MAPK targets/ Nuclear events mediated by MAP kinases (Homo sapiens)
        
        ERK/MAPK targets (Homo sapiens)
        
        ERK5 activates the transcription factor MEF2 (Homo sapiens)
        
        MEF2 [nucleoplasm] (Homo sapiens)
        
        MEF2A [nucleoplasm] (Homo sapiens)
    - Toll Like Receptor 2 (TLR2) Cascade (Homo sapiens)
      - Toll Like Receptor TLR1:TLR2 Cascade (Homo sapiens)
        
        MyD88:MAL(TIRAP) cascade initiated on plasma membrane (Homo sapiens)
        
        MAP kinase activation (Homo sapiens)
        
        MAPK targets/ Nuclear events mediated by MAP kinases (Homo sapiens)
        
        ERK/MAPK targets (Homo sapiens)
        
        ERK5 activates the transcription factor MEF2 (Homo sapiens)
        
        MEF2 [nucleoplasm] (Homo sapiens)
        
        MEF2A [nucleoplasm] (Homo sapiens)
      - Toll Like Receptor TLR6:TLR2 Cascade (Homo sapiens)
        
        MyD88:MAL(TIRAP) cascade initiated on plasma membrane (Homo sapiens)
        
        MAP kinase activation (Homo sapiens)
        
        MAPK targets/ Nuclear events mediated by MAP kinases (Homo sapiens)
        
        ERK/MAPK targets (Homo sapiens)
        
        ERK5 activates the transcription factor MEF2 (Homo sapiens)
        
        MEF2 [nucleoplasm] (Homo sapiens)
        
        MEF2A [nucleoplasm] (Homo sapiens)
    - Toll Like Receptor 3 (TLR3) Cascade (Homo sapiens)
      - MAP kinase activation (Homo sapiens)
        
        MAPK targets/ Nuclear events mediated by MAP kinases (Homo sapiens)
        
        ERK/MAPK targets (Homo sapiens)
        
        ERK5 activates the transcription factor MEF2 (Homo sapiens)
        
        MEF2 [nucleoplasm] (Homo sapiens)
        
        MEF2A [nucleoplasm] (Homo sapiens)
    - Toll Like Receptor 4 (TLR4) Cascade (Homo sapiens)
      - MyD88-independent TLR4 cascade (Homo sapiens)
        
        TRIF (TICAM1)-mediated TLR4 signaling (Homo sapiens)
        
        MAP kinase activation (Homo sapiens)
        
        MAPK targets/ Nuclear events mediated by MAP kinases (Homo sapiens)
        
        ERK/MAPK targets (Homo sapiens)
        
        ERK5 activates the transcription factor MEF2 (Homo sapiens)
        
        MEF2 [nucleoplasm] (Homo sapiens)
        
        MEF2A [nucleoplasm] (Homo sapiens)
      - MyD88:MAL(TIRAP) cascade initiated on plasma membrane (Homo sapiens)
        
        MAP kinase activation (Homo sapiens)
        
        MAPK targets/ Nuclear events mediated by MAP kinases (Homo sapiens)
        
        ERK/MAPK targets (Homo sapiens)
        
        ERK5 activates the transcription factor MEF2 (Homo sapiens)
        
        MEF2 [nucleoplasm] (Homo sapiens)
        
        MEF2A [nucleoplasm] (Homo sapiens)
    - Toll Like Receptor 5 (TLR5) Cascade (Homo sapiens)
      - MyD88 cascade initiated on plasma membrane (Homo sapiens)
        
        MAP kinase activation (Homo sapiens)
        
        MAPK targets/ Nuclear events mediated by MAP kinases (Homo sapiens)
        
        ERK/MAPK targets (Homo sapiens)
        
        ERK5 activates the transcription factor MEF2 (Homo sapiens)
        
        MEF2 [nucleoplasm] (Homo sapiens)
        
        MEF2A [nucleoplasm] (Homo sapiens)
    - Toll Like Receptor 7/8 (TLR7/8) Cascade (Homo sapiens)
      - MyD88 dependent cascade initiated on endosome (Homo sapiens)
        
        TRAF6 mediated induction of NFkB and MAP kinases upon TLR7/8 or 9 activation (Homo sapiens)
        
        MAP kinase activation (Homo sapiens)
        
        MAPK targets/ Nuclear events mediated by MAP kinases (Homo sapiens)
        
        ERK/MAPK targets (Homo sapiens)
        
        ERK5 activates the transcription factor MEF2 (Homo sapiens)
        
        MEF2 [nucleoplasm] (Homo sapiens)
        
        MEF2A [nucleoplasm] (Homo sapiens)
    - Toll Like Receptor 9 (TLR9) Cascade (Homo sapiens)
      - MyD88 dependent cascade initiated on endosome (Homo sapiens)
        
        TRAF6 mediated induction of NFkB and MAP kinases upon TLR7/8 or 9 activation (Homo sapiens)
        
        MAP kinase activation (Homo sapiens)
        
        MAPK targets/ Nuclear events mediated by MAP kinases (Homo sapiens)
        
        ERK/MAPK targets (Homo sapiens)
        
        ERK5 activates the transcription factor MEF2 (Homo sapiens)
        
        MEF2 [nucleoplasm] (Homo sapiens)
        
        MEF2A [nucleoplasm] (Homo sapiens)

Signal Transduction (Homo sapiens)

- Signaling by Receptor Tyrosine Kinases (Homo sapiens)
  - Signaling by NTRKs (Homo sapiens)
    - Signaling by NTRK1 (TRKA) (Homo sapiens)
      - Nuclear Events (kinase and transcription factor activation) (Homo sapiens)
        
        ERK/MAPK targets (Homo sapiens)
        
        ERK5 activates the transcription factor MEF2 (Homo sapiens)
        
        MEF2 [nucleoplasm] (Homo sapiens)
        
        MEF2A [nucleoplasm] (Homo sapiens)

External Reference Information

External Reference

UniProt:Q02078 MEF2A

Gene Names

MEF2A, MEF2

Chain

chain:1-507

Reference Genes

BioGPS Gene:4205 MEF2A

COSMIC (genes):MEF2A MEF2A

CTD Gene:4205 MEF2A

dbSNP Gene:4205 MEF2A

ENSEMBL:ENSG00000068305 MEF2A

HGNC:6993 MEF2A

KEGG:hsa:4205 MEF2A

Monarch:4205 MEF2A

NCBI Gene:4205 MEF2A

OMIM:600660 MEF2A

UCSC:Q02078 MEF2A

Reference Transcript

Participates

as a member of

Other forms of this molecule

p-S408-MEF2A [nucleoplasm]

p-T312,T319-MEF2A [nucleoplasm]

Inferred To

SMP1 [nucleoplasm] (Saccharomyces cerevisiae)

pvg4 [nucleoplasm] (Schizosaccharomyces pombe)

mef2A [nucleoplasm] (Dictyostelium discoideum)

Mef2a [nucleoplasm] (Rattus norvegicus)

Mef2 [nucleoplasm] (Drosophila melanogaster)

mbx1 [nucleoplasm] (Schizosaccharomyces pombe)

srfD [nucleoplasm] (Dictyostelium discoideum)

Homologues of MEF2A [nucleoplasm] (Dictyostelium discoideum)

Homologues of MEF2A [nucleoplasm] (Saccharomyces cerevisiae)

Homologues of MEF2A [nucleoplasm] (Schizosaccharomyces pombe)

mef-2 [nucleoplasm] (Caenorhabditis elegans)

RLM1 [nucleoplasm] (Saccharomyces cerevisiae)

MEF2A [nucleoplasm] (Sus scrofa)

Cross References

RefSeq

XP_054233920.1, NP_001339544.1, NP_001352138.1, XP_047288481.1, XP_047288487.1, NP_001386988.1, NP_001386980.1, NP_001386961.1, XP_047288485.1, NP_001386959.1, NP_001386967.1, NP_001165365.1, NP_001386992.1, XP_047288478.1, XP_054233924.1, NP_001339546.1, XP_054233918.1, NP_001386985.1, NP_001386981.1, XP_054233921.1, NP_001339543.1, NP_001386958.1, XP_047288484.1, NP_001339545.1, NP_001124398.1, NP_001386991.1, NP_001386983.1, XP_054233916.1, NP_001380488.1, XP_047288477.1, NP_001386995.1, NP_001386986.1, XP_047288482.1, NP_001386978.1, NP_001386984.1, NP_001386965.1, XP_011519884.1, NP_001124399.1, NP_001352132.1, XP_054233922.1, XP_054233917.1, XP_011519888.1, NP_001386969.1, NP_001386994.1, NP_001386990.1, NP_005578.2, XP_054233926.1, NP_001386979.1, NP_001352136.1, XP_016877683.1, NP_001352134.1, XP_011519883.1, NP_001124400.1, NP_001386960.1, NP_001386964.1, XP_047288486.1, NP_001352133.1, NP_001352137.1, NP_001386987.1, NP_001386962.1, NP_001386968.1, XP_016877679.1, XP_016877682.1, NP_001386993.1, NP_001386982.1, NP_001386963.1, XP_054233927.1, XP_054233925.1, XP_047288480.1, NP_001306135.1, XP_016877680.1, NP_001386989.1

OpenTargets

ENSG00000068305

ENSEMBL

ENSG00000068305, ENST00000449277, ENSP00000454120, ENSP00000453095, ENST00000691492, ENST00000686611, ENSP00000509137, ENSP00000346389, ENST00000557942, ENST00000558812, ENSP00000509537, ENST00000354410, ENST00000557785, ENSP00000399460, ENSP00000453441

HPA

ENSG00000068305-MEF2A

GeneCards

MEF2A

PRO

Q02078

Pharos - Targets

Q02078

GlyGen

Q02078

PDB

1C7U, 6BZ1, 3P57, 3MU6, 7XUZ, 1LEW, 3KOV, 6BYY, 1EGW

Interactors (4)

Accession	#Entities	Entities	Confidence Score	Evidence (IntAct)
UniProt:Q14814 MEF2D	1	MEF2D [nucleoplasm] (R-HSA-445328)	0.527	3
UniProt:Q06413 MEF2C	3	MEF2C [nucleoplasm] (R-HSA-199938) p-S396-MEF2C [nucleoplasm] (R-HSA-199942) p-T293,T300,S387-MEF2C [nucleoplasm] (R-HSA-448838)	0.527	3
UniProt:P56524 HDAC4	3	HDAC4 [nucleoplasm] (R-HSA-351581) monoSUMO1-K559-HDAC4 [nucleoplasm] (R-HSA-4616016) polySUMO2,3-K559-HDAC4 [nucleoplasm] (R-HSA-4616029)	0.489	2
UniProt:P05412 JUN	4	JUN [nucleoplasm] (R-HSA-450250) p-S63,S73-JUN [nucleoplasm] (R-HSA-450237) JUN [cytosol] (R-HSA-168194) p-S63,S73-JUN [cytosol] (R-HSA-8868682)	0.462	4

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