Reactome | MEF2A [nucleoplasm]

MEF2A [nucleoplasm]

Stable Identifier

R-HSA-199903

Type

Protein [EntityWithAccessionedSequence]

Species

Homo sapiens

Compartment

nucleoplasm

Synonyms

Myocyte-specific enhancer factor 2A, MEFA_HUMAN

Locations in the PathwayBrowser

Expand all

Immune System (Homo sapiens)

- Cytokine Signaling in Immune system (Homo sapiens)
  - Signaling by Interleukins (Homo sapiens)
    - Interleukin-17 signaling (Homo sapiens)
      - MAP kinase activation (Homo sapiens)
        
        MAPK targets/ Nuclear events mediated by MAP kinases (Homo sapiens)
        
        ERK/MAPK targets (Homo sapiens)
        
        ERK5 activates the transcription factor MEF2 (Homo sapiens)
        
        MEF2 [nucleoplasm] (Homo sapiens)
        
        MEF2A [nucleoplasm] (Homo sapiens)
- Innate Immune System (Homo sapiens)
  - Toll-like Receptor Cascades (Homo sapiens)
    - Toll Like Receptor 10 (TLR10) Cascade (Homo sapiens)
      - MyD88 cascade initiated on plasma membrane (Homo sapiens)
        
        MAP kinase activation (Homo sapiens)
        
        MAPK targets/ Nuclear events mediated by MAP kinases (Homo sapiens)
        
        ERK/MAPK targets (Homo sapiens)
        
        ERK5 activates the transcription factor MEF2 (Homo sapiens)
        
        MEF2 [nucleoplasm] (Homo sapiens)
        
        MEF2A [nucleoplasm] (Homo sapiens)
    - Toll Like Receptor 2 (TLR2) Cascade (Homo sapiens)
      - Toll Like Receptor TLR1:TLR2 Cascade (Homo sapiens)
        
        MyD88:MAL(TIRAP) cascade initiated on plasma membrane (Homo sapiens)
        
        MAP kinase activation (Homo sapiens)
        
        MAPK targets/ Nuclear events mediated by MAP kinases (Homo sapiens)
        
        ERK/MAPK targets (Homo sapiens)
        
        ERK5 activates the transcription factor MEF2 (Homo sapiens)
        
        MEF2 [nucleoplasm] (Homo sapiens)
        
        MEF2A [nucleoplasm] (Homo sapiens)
      - Toll Like Receptor TLR6:TLR2 Cascade (Homo sapiens)
        
        MyD88:MAL(TIRAP) cascade initiated on plasma membrane (Homo sapiens)
        
        MAP kinase activation (Homo sapiens)
        
        MAPK targets/ Nuclear events mediated by MAP kinases (Homo sapiens)
        
        ERK/MAPK targets (Homo sapiens)
        
        ERK5 activates the transcription factor MEF2 (Homo sapiens)
        
        MEF2 [nucleoplasm] (Homo sapiens)
        
        MEF2A [nucleoplasm] (Homo sapiens)
    - Toll Like Receptor 3 (TLR3) Cascade (Homo sapiens)
      - MAP kinase activation (Homo sapiens)
        
        MAPK targets/ Nuclear events mediated by MAP kinases (Homo sapiens)
        
        ERK/MAPK targets (Homo sapiens)
        
        ERK5 activates the transcription factor MEF2 (Homo sapiens)
        
        MEF2 [nucleoplasm] (Homo sapiens)
        
        MEF2A [nucleoplasm] (Homo sapiens)
    - Toll Like Receptor 4 (TLR4) Cascade (Homo sapiens)
      - MyD88-independent TLR4 cascade (Homo sapiens)
        
        TRIF(TICAM1)-mediated TLR4 signaling (Homo sapiens)
        
        MAP kinase activation (Homo sapiens)
        
        MAPK targets/ Nuclear events mediated by MAP kinases (Homo sapiens)
        
        ERK/MAPK targets (Homo sapiens)
        
        ERK5 activates the transcription factor MEF2 (Homo sapiens)
        
        MEF2 [nucleoplasm] (Homo sapiens)
        
        MEF2A [nucleoplasm] (Homo sapiens)
      - MyD88:MAL(TIRAP) cascade initiated on plasma membrane (Homo sapiens)
        
        MAP kinase activation (Homo sapiens)
        
        MAPK targets/ Nuclear events mediated by MAP kinases (Homo sapiens)
        
        ERK/MAPK targets (Homo sapiens)
        
        ERK5 activates the transcription factor MEF2 (Homo sapiens)
        
        MEF2 [nucleoplasm] (Homo sapiens)
        
        MEF2A [nucleoplasm] (Homo sapiens)
    - Toll Like Receptor 5 (TLR5) Cascade (Homo sapiens)
      - MyD88 cascade initiated on plasma membrane (Homo sapiens)
        
        MAP kinase activation (Homo sapiens)
        
        MAPK targets/ Nuclear events mediated by MAP kinases (Homo sapiens)
        
        ERK/MAPK targets (Homo sapiens)
        
        ERK5 activates the transcription factor MEF2 (Homo sapiens)
        
        MEF2 [nucleoplasm] (Homo sapiens)
        
        MEF2A [nucleoplasm] (Homo sapiens)
    - Toll Like Receptor 7/8 (TLR7/8) Cascade (Homo sapiens)
      - MyD88 dependent cascade initiated on endosome (Homo sapiens)
        
        TRAF6 mediated induction of NFkB and MAP kinases upon TLR7/8 or 9 activation (Homo sapiens)
        
        MAP kinase activation (Homo sapiens)
        
        MAPK targets/ Nuclear events mediated by MAP kinases (Homo sapiens)
        
        ERK/MAPK targets (Homo sapiens)
        
        ERK5 activates the transcription factor MEF2 (Homo sapiens)
        
        MEF2 [nucleoplasm] (Homo sapiens)
        
        MEF2A [nucleoplasm] (Homo sapiens)
    - Toll Like Receptor 9 (TLR9) Cascade (Homo sapiens)
      - MyD88 dependent cascade initiated on endosome (Homo sapiens)
        
        TRAF6 mediated induction of NFkB and MAP kinases upon TLR7/8 or 9 activation (Homo sapiens)
        
        MAP kinase activation (Homo sapiens)
        
        MAPK targets/ Nuclear events mediated by MAP kinases (Homo sapiens)
        
        ERK/MAPK targets (Homo sapiens)
        
        ERK5 activates the transcription factor MEF2 (Homo sapiens)
        
        MEF2 [nucleoplasm] (Homo sapiens)
        
        MEF2A [nucleoplasm] (Homo sapiens)

Signal Transduction (Homo sapiens)

- Signaling by Receptor Tyrosine Kinases (Homo sapiens)
  - Signaling by NTRKs (Homo sapiens)
    - Signaling by NTRK1 (TRKA) (Homo sapiens)
      - Nuclear Events (kinase and transcription factor activation) (Homo sapiens)
        
        ERK/MAPK targets (Homo sapiens)
        
        ERK5 activates the transcription factor MEF2 (Homo sapiens)
        
        MEF2 [nucleoplasm] (Homo sapiens)
        
        MEF2A [nucleoplasm] (Homo sapiens)

External Reference Information

External Reference

UniProt:Q02078 MEF2A

Gene Names

MEF2A, MEF2

Chain

chain:1-507

Reference Genes

BioGPS Gene:4205 MEF2A

COSMIC (genes):MEF2A MEF2A

CTD Gene:4205 MEF2A

dbSNP Gene:4205 MEF2A

ENSEMBL:ENSG00000068305 MEF2A

ENSEMBL:ENSG00000068305.19 MEF2A

HGNC:6993 MEF2A

KEGG Gene (Homo sapiens):4205 MEF2A

Monarch:4205 MEF2A

NCBI Gene:4205 MEF2A

OMIM:600660 MEF2A

UCSC:Q02078 MEF2A

Reference Transcript

Other Identifiers

11718096_a_at

11718097_a_at

11724863_a_at

11735491_a_at

16805594

208328_PM_s_at

208328_s_at

212535_PM_at

212535_at

214684_3p_at

214684_PM_at

214684_at

3611172

3611173

3611174

3611175

3611176

3611177

3611189

3611198

3611199

3611201

3611219

3611221

3611222

3611223

3611229

3611230

3611247

3611250

3611251

3611255

3611256

3611257

3611258

3611259

3611260

3611261

3611262

3611263

3611264

41747_s_at

4205

44865_s_at

7986411

A_14_P133989

A_23_P353652

A_24_P1731

A_33_P3341676

GE81532

GO:0000002

GO:0000122

GO:0000165

GO:0000785

GO:0000977

GO:0000978

GO:0000981

GO:0001228

GO:0003012

GO:0003013

GO:0003677

GO:0003682

GO:0003700

GO:0005515

GO:0005634

GO:0005654

GO:0005667

GO:0005694

GO:0005829

GO:0006351

GO:0006355

GO:0006915

GO:0007005

GO:0007010

GO:0007399

GO:0007507

GO:0007517

GO:0010613

GO:0010628

GO:0012501

GO:0019901

GO:0023052

GO:0030154

GO:0035035

GO:0042826

GO:0043226

GO:0043229

GO:0043565

GO:0045893

GO:0045944

GO:0046326

GO:0046332

GO:0046982

GO:0046983

GO:0048311

GO:0048513

GO:0048813

GO:0048856

GO:0055005

GO:0055085

GO:0061337

GO:0061629

GO:0070375

GO:0071277

GO:0140110

GO:0140297

HMNXSV003023441

HMNXSV003026888

Hs.182280.2.S1_3p_at

Hs.182280.2.S1_3p_x_at

Hs.288993.0.A1_3p_at

ILMN_1661888

PH_hs_0025001

TC15000955.hg

TC15002404.hg

U49020_cds2_s_at

X68505_s_at

g5031906_3p_a_at

Participates

as a member of

Other forms of this molecule

p-T312,T319-MEF2A [nucleoplasm]

p-S408-MEF2A [nucleoplasm]

Inferred To

SMP1 [nucleoplasm] (Saccharomyces cerevisiae)

mef2A [nucleoplasm] (Dictyostelium discoideum)

Mef2a [nucleoplasm] (Mus musculus)

Mef2a [nucleoplasm] (Rattus norvegicus)

Mef2 [nucleoplasm] (Drosophila melanogaster)

MEF2D [nucleoplasm] (Gallus gallus)

RLM1 [nucleoplasm] (Saccharomyces cerevisiae)

pvg4 [nucleoplasm] (Schizosaccharomyces pombe)

mbx1 [nucleoplasm] (Schizosaccharomyces pombe)

MEF2B [nucleoplasm] (Danio rerio)

srfD [nucleoplasm] (Dictyostelium discoideum)

Homologues of MEF2A [nucleoplasm] (Danio rerio)

Homologues of MEF2A [nucleoplasm] (Dictyostelium discoideum)

Homologues of MEF2A [nucleoplasm] (Saccharomyces cerevisiae)

Homologues of MEF2A [nucleoplasm] (Schizosaccharomyces pombe)

mef-2 [nucleoplasm] (Caenorhabditis elegans)

MEF2A [nucleoplasm] (Canis familiaris)

MEF2A [nucleoplasm] (Danio rerio)

MEF2A [nucleoplasm] (Sus scrofa)

Cross References

RefSeq

NP_001124400.1, NP_001165365.1, XP_016877679.1, XP_016877680.1, XP_011519888.1, NP_001124399.1, XP_011519884.1, XP_016877683.1, XP_016877682.1, NP_005578.2, NP_001306135.1, XP_011519883.1

OpenTargets

ENSG00000068305

GeneCards

Q02078

HPA

ENSG00000068305-MEF2A

Ensembl

ENST00000449277, ENSP00000453095, ENSP00000399460, ENST00000557785, ENSP00000454120, ENST00000691492, ENST00000558812, ENSP00000509137, ENST00000557942, ENSP00000509537, ENSP00000453441, ENSP00000346389, ENSG00000068305, ENST00000354410, ENST00000686611

PRO

Q02078

Pharos - Targets

Q02078

Orphanet

23149

PDB

6BYY, 6BZ1, 1EGW, 3P57, 3KOV, 1LEW, 3MU6, 1C7U

Interactors (2)

Accession	#Entities	Entities	Confidence Score	Evidence (IntAct)
UniProt:P56524 HDAC4	3	polySUMO2,3-K559-HDAC4 [nucleoplasm] (R-HSA-4616029) monoSUMO1-K559-HDAC4 [nucleoplasm] (R-HSA-4616016) HDAC4 [nucleoplasm] (R-HSA-351581)	0.489	2
UniProt:P05412 JUN	4	JUN [nucleoplasm] (R-HSA-450250) p-S63,S73-JUN [nucleoplasm] (R-HSA-450237) JUN [cytosol] (R-HSA-168194) p-S63,S73-JUN [cytosol] (R-HSA-8868682)	0.462	4

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