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MEF2A [nucleoplasm]
Stable Identifier
R-HSA-199903
Type
Protein [EntityWithAccessionedSequence]
Species
Homo sapiens
Compartment
nucleoplasm
Synonyms
Myocyte-specific enhancer factor 2A, MEFA_HUMAN
Locations in the PathwayBrowser
Expand all
Developmental Biology (Homo sapiens)
Myogenesis (Homo sapiens)
Phosphorylation of MEF2 proteins by p38 (Homo sapiens)
MEF2 proteins [nucleoplasm] (Homo sapiens)
MEF2A [nucleoplasm] (Homo sapiens)
Immune System (Homo sapiens)
Cytokine Signaling in Immune system (Homo sapiens)
Signaling by Interleukins (Homo sapiens)
Interleukin-17 signaling (Homo sapiens)
MAP kinase activation (Homo sapiens)
MAPK targets/ Nuclear events mediated by MAP kinases (Homo sapiens)
ERK/MAPK targets (Homo sapiens)
ERK5 activates the transcription factor MEF2 (Homo sapiens)
MEF2 [nucleoplasm] (Homo sapiens)
MEF2A [nucleoplasm] (Homo sapiens)
Innate Immune System (Homo sapiens)
Toll-like Receptor Cascades (Homo sapiens)
Toll Like Receptor 10 (TLR10) Cascade (Homo sapiens)
MyD88 cascade initiated on plasma membrane (Homo sapiens)
MAP kinase activation (Homo sapiens)
MAPK targets/ Nuclear events mediated by MAP kinases (Homo sapiens)
ERK/MAPK targets (Homo sapiens)
ERK5 activates the transcription factor MEF2 (Homo sapiens)
MEF2 [nucleoplasm] (Homo sapiens)
MEF2A [nucleoplasm] (Homo sapiens)
Toll Like Receptor 2 (TLR2) Cascade (Homo sapiens)
Toll Like Receptor TLR1:TLR2 Cascade (Homo sapiens)
MyD88:MAL(TIRAP) cascade initiated on plasma membrane (Homo sapiens)
MAP kinase activation (Homo sapiens)
MAPK targets/ Nuclear events mediated by MAP kinases (Homo sapiens)
ERK/MAPK targets (Homo sapiens)
ERK5 activates the transcription factor MEF2 (Homo sapiens)
MEF2 [nucleoplasm] (Homo sapiens)
MEF2A [nucleoplasm] (Homo sapiens)
Toll Like Receptor TLR6:TLR2 Cascade (Homo sapiens)
MyD88:MAL(TIRAP) cascade initiated on plasma membrane (Homo sapiens)
MAP kinase activation (Homo sapiens)
MAPK targets/ Nuclear events mediated by MAP kinases (Homo sapiens)
ERK/MAPK targets (Homo sapiens)
ERK5 activates the transcription factor MEF2 (Homo sapiens)
MEF2 [nucleoplasm] (Homo sapiens)
MEF2A [nucleoplasm] (Homo sapiens)
Toll Like Receptor 3 (TLR3) Cascade (Homo sapiens)
MAP kinase activation (Homo sapiens)
MAPK targets/ Nuclear events mediated by MAP kinases (Homo sapiens)
ERK/MAPK targets (Homo sapiens)
ERK5 activates the transcription factor MEF2 (Homo sapiens)
MEF2 [nucleoplasm] (Homo sapiens)
MEF2A [nucleoplasm] (Homo sapiens)
Toll Like Receptor 4 (TLR4) Cascade (Homo sapiens)
MyD88-independent TLR4 cascade (Homo sapiens)
TRIF(TICAM1)-mediated TLR4 signaling (Homo sapiens)
MAP kinase activation (Homo sapiens)
MAPK targets/ Nuclear events mediated by MAP kinases (Homo sapiens)
ERK/MAPK targets (Homo sapiens)
ERK5 activates the transcription factor MEF2 (Homo sapiens)
MEF2 [nucleoplasm] (Homo sapiens)
MEF2A [nucleoplasm] (Homo sapiens)
MyD88:MAL(TIRAP) cascade initiated on plasma membrane (Homo sapiens)
MAP kinase activation (Homo sapiens)
MAPK targets/ Nuclear events mediated by MAP kinases (Homo sapiens)
ERK/MAPK targets (Homo sapiens)
ERK5 activates the transcription factor MEF2 (Homo sapiens)
MEF2 [nucleoplasm] (Homo sapiens)
MEF2A [nucleoplasm] (Homo sapiens)
Toll Like Receptor 5 (TLR5) Cascade (Homo sapiens)
MyD88 cascade initiated on plasma membrane (Homo sapiens)
MAP kinase activation (Homo sapiens)
MAPK targets/ Nuclear events mediated by MAP kinases (Homo sapiens)
ERK/MAPK targets (Homo sapiens)
ERK5 activates the transcription factor MEF2 (Homo sapiens)
MEF2 [nucleoplasm] (Homo sapiens)
MEF2A [nucleoplasm] (Homo sapiens)
Toll Like Receptor 7/8 (TLR7/8) Cascade (Homo sapiens)
MyD88 dependent cascade initiated on endosome (Homo sapiens)
TRAF6 mediated induction of NFkB and MAP kinases upon TLR7/8 or 9 activation (Homo sapiens)
MAP kinase activation (Homo sapiens)
MAPK targets/ Nuclear events mediated by MAP kinases (Homo sapiens)
ERK/MAPK targets (Homo sapiens)
ERK5 activates the transcription factor MEF2 (Homo sapiens)
MEF2 [nucleoplasm] (Homo sapiens)
MEF2A [nucleoplasm] (Homo sapiens)
Toll Like Receptor 9 (TLR9) Cascade (Homo sapiens)
MyD88 dependent cascade initiated on endosome (Homo sapiens)
TRAF6 mediated induction of NFkB and MAP kinases upon TLR7/8 or 9 activation (Homo sapiens)
MAP kinase activation (Homo sapiens)
MAPK targets/ Nuclear events mediated by MAP kinases (Homo sapiens)
ERK/MAPK targets (Homo sapiens)
ERK5 activates the transcription factor MEF2 (Homo sapiens)
MEF2 [nucleoplasm] (Homo sapiens)
MEF2A [nucleoplasm] (Homo sapiens)
Signal Transduction (Homo sapiens)
Signaling by Receptor Tyrosine Kinases (Homo sapiens)
Signaling by NTRKs (Homo sapiens)
Signaling by NTRK1 (TRKA) (Homo sapiens)
Nuclear Events (kinase and transcription factor activation) (Homo sapiens)
ERK/MAPK targets (Homo sapiens)
ERK5 activates the transcription factor MEF2 (Homo sapiens)
MEF2 [nucleoplasm] (Homo sapiens)
MEF2A [nucleoplasm] (Homo sapiens)
External Reference Information
External Reference
UniProt:Q02078 MEF2A
Gene Names
MEF2A, MEF2
Chain
chain:1-507
Reference Genes
BioGPS Gene:4205 MEF2A
COSMIC (genes):MEF2A MEF2A
CTD Gene:4205 MEF2A
dbSNP Gene:4205 MEF2A
ENSEMBL:ENSG00000068305 MEF2A
HGNC:6993 MEF2A
KEGG Gene (Homo sapiens):4205 MEF2A
Monarch:4205 MEF2A
NCBI Gene:4205 MEF2A
OMIM:600660 MEF2A
UCSC:Q02078 MEF2A
Reference Transcript
RefSeq:NM_001319206.1 MEF2A
RefSeq:XM_011521586.2 MEF2A
RefSeq:NM_001130927.2 MEF2A
RefSeq:NM_005587.3 MEF2A
RefSeq:XM_017022190.1 MEF2A
RefSeq:XM_017022194.1 MEF2A
RefSeq:NM_001130928.2 MEF2A
RefSeq:XM_011521581.2 MEF2A
RefSeq:XM_017022191.1 MEF2A
RefSeq:NM_001171894.2 MEF2A
RefSeq:XM_011521582.2 MEF2A
RefSeq:XM_017022193.1 MEF2A
Other Identifiers
0002690048
11718096_a_at
11718097_a_at
11724863_a_at
11735491_a_at
16805594
208328_s_at
212535_at
214684_3p_at
214684_at
3611172
3611173
3611174
3611175
3611176
3611177
3611189
3611198
3611199
3611201
3611219
3611221
3611222
3611223
3611229
3611230
3611247
3611250
3611251
3611255
3611256
3611257
3611258
3611259
3611260
3611261
3611262
3611263
3611264
41747_s_at
4205
44865_s_at
7986411
A_14_P133989
A_23_P353652
A_24_P1731
A_33_P3341676
GE81532
GO:0000002
GO:0000122
GO:0000165
GO:0000785
GO:0000902
GO:0000977
GO:0000978
GO:0000981
GO:0001085
GO:0001228
GO:0003013
GO:0003674
GO:0003677
GO:0003682
GO:0003700
GO:0005515
GO:0005575
GO:0005622
GO:0005634
GO:0005654
GO:0005667
GO:0005694
GO:0005737
GO:0005829
GO:0006351
GO:0006355
GO:0006357
GO:0006464
GO:0006810
GO:0006915
GO:0007005
GO:0007010
GO:0007165
GO:0007275
GO:0007399
GO:0007507
GO:0007517
GO:0008134
GO:0008150
GO:0008219
GO:0009058
GO:0010613
GO:0010628
GO:0019899
GO:0019901
GO:0022607
GO:0030154
GO:0032991
GO:0033613
GO:0034641
GO:0035035
GO:0042826
GO:0043226
GO:0043565
GO:0045893
GO:0045944
GO:0046326
GO:0046332
GO:0046982
GO:0046983
GO:0048311
GO:0048646
GO:0048813
GO:0048856
GO:0051149
GO:0055005
GO:0055085
GO:0061337
GO:0070375
GO:0071277
HMNXSV003023441
HMNXSV003026888
Hs.182280.2.S1_3p_at
Hs.182280.2.S1_3p_x_at
Hs.288993.0.A1_3p_at
ILMN_1661888
ILMN_3249825
ILMN_3251100
PH_hs_0025001
TC15000955.hg
TC15002404.hg
U49020_cds2_s_at
X68505_s_at
g5031906_3p_a_at
Participates
as a member of
MEF2 proteins [nucleoplasm] (Homo sapiens)
MEF2 [nucleoplasm] (Homo sapiens)
Other forms of this molecule
p-T312,T319-MEF2A [nucleoplasm]
p-S408-MEF2A [nucleoplasm]
Inferred To
SMP1 [nucleoplasm]
(Saccharomyces cerevisiae)
pvg4 [nucleoplasm]
(Schizosaccharomyces pombe)
mef2A [nucleoplasm]
(Dictyostelium discoideum)
Mef2a [nucleoplasm]
(Mus musculus)
Mef2a [nucleoplasm]
(Rattus norvegicus)
Mef2 [nucleoplasm]
(Drosophila melanogaster)
srfD [nucleoplasm]
(Dictyostelium discoideum)
Homologues of MEF2A [nucleoplasm]
(Dictyostelium discoideum)
Homologues of MEF2A [nucleoplasm]
(Saccharomyces cerevisiae)
mef-2 [nucleoplasm]
(Caenorhabditis elegans)
mef2aa [nucleoplasm]
(Danio rerio)
RLM1 [nucleoplasm]
(Saccharomyces cerevisiae)
MEF2A [nucleoplasm]
(Canis familiaris)
MEF2A [nucleoplasm]
(Sus scrofa)
Cross References
RefSeq
NP_001124400.1
,
NP_001165365.1
,
XP_016877680.1
,
XP_011519888.1
,
XP_016877682.1
,
NP_005578.2
,
NP_001306135.1
,
NP_001124399.1
,
XP_016877679.1
,
XP_011519883.1
,
XP_016877683.1
,
XP_011519884.1
OpenTargets
ENSG00000068305
HPA
ENSG00000068305-MEF2A
GeneCards
Q02078
Ensembl
ENSP00000399460
,
ENST00000557785
,
ENST00000449277
,
ENSP00000337202
,
ENST00000354410
,
ENSG00000068305
,
ENST00000338042
,
ENSP00000453441
,
ENSP00000346389
,
ENST00000557942
,
ENSP00000453095
,
ENSP00000454120
,
ENST00000558812
PRO
Q02078
Pharos - Targets
Q02078
Orphanet
23149
GlyGen
Q02078
PDB
6BYY
,
1C7U
,
3MU6
,
3KOV
,
1EGW
,
6BZ1
,
1LEW
,
3P57
Interactors (2)
Accession
#Entities
Entities
Confidence Score
Evidence (IntAct)
UniProt:P56524 HDAC4
3
polySUMO2,3-K559-HDAC4 [nucleoplasm]
(R-HSA-4616029)
monoSUMO1-K559-HDAC4 [nucleoplasm]
(R-HSA-4616016)
HDAC4 [nucleoplasm]
(R-HSA-351581)
0.489
2
UniProt:P05412 JUN
4
JUN [nucleoplasm]
(R-HSA-450250)
p-S63,S73-JUN [nucleoplasm]
(R-HSA-450237)
JUN [cytosol]
(R-HSA-168194)
p-S63,S73-JUN [cytosol]
(R-HSA-8868682)
0.462
4
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