THEM4 (CTMP) and/or TRIB3 inhibit AKT phosphorylation

Stable Identifier
R-HSA-199443
Type
Reaction [binding]
Species
Homo sapiens
Compartment
ReviewStatus
5/5
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The phosphorylation of membrane-recruited AKT at threonine and serine can be inhibited by direct binding of two different proteins, C-terminal modulator protein (THEM4 i.e. CTMP), which binds to the carboxy-terminal tail of AKT (Maira et al. 2001), or Tribbles homolog 3 (TRIB3), which binds to the catalytic domain of AKT (Du et al. 2003).
Literature References
PubMed ID Title Journal Year
12791994 TRB3: a tribbles homolog that inhibits Akt/PKB activation by insulin in liver

Kulkarni, RN, Herzig, S, Du, K, Montminy, M

Science 2003
11598301 Carboxyl-terminal modulator protein (CTMP), a negative regulator of PKB/Akt and v-Akt at the plasma membrane

Kaech, S, Maira, SM, Brazil, DP, Galetic, I, Ingley, E, Thelen, M, Hemmings, BA

Science 2001
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