Toggle navigation
About
What is Reactome ?
News
Team
Scientific Advisory Board
Funding
Editorial Calendar
Release Calendar
Statistics
Our Logo
License Agreement
Privacy Notice
Disclaimer
Digital Preservation
Contact us
Content
Table of Contents
DOIs
Data Schema
Reactome Research Spotlight
ORCID Integration Project
COVID-19 Disease Pathways
Docs
Userguide
Pathway Browser
How do I search ?
Details Panel
Analysis Tools
Analysis Data
Analysis Gene Expression
Species Comparison
Tissue Distribution
Diseases
Cytomics
Review Status of Reactome Events
ReactomeFIViz
Developer's Zone
Graph Database
Analysis Service
Content Service
Pathways Overview
Pathway Diagrams
Icon Info
EHLD Specs & Guidelines
Icon Library Guidelines
Data Model
Curator Guide
Release Documentation
Computationally inferred events
FAQ
Linking to Us
Citing us
Tools
Pathway Browser
Analyse gene list
Analyse gene expression
Species Comparison
Tissue Distribution
Analysis Service
Content Service
ReactomeFIViz
Advanced Data Search
Site Search
Community
Contribute Pathway Knowledge
Icon Library
Outreach
Events
Publications
Partners
Contributors
Resources Guide
Download
About
What is Reactome ?
News
Team
Scientific Advisory Board
Funding
Editorial Calendar
Release Calendar
Statistics
Our Logo
License Agreement
Privacy Notice
Disclaimer
Digital Preservation
Contact us
Content
Table of Contents
DOIs
Data Schema
Reactome Research Spotlight
ORCID Integration Project
COVID-19 Disease Pathways
Docs
Userguide
Pathway Browser
How do I search ?
Details Panel
Analysis Tools
Analysis Data
Analysis Gene Expression
Species Comparison
Tissue Distribution
Diseases
Cytomics
Review Status of Reactome Events
ReactomeFIViz
Developer's Zone
Graph Database
Analysis Service
Content Service
Pathways Overview
Pathway Diagrams
Icon Info
EHLD Specs & Guidelines
Icon Library Guidelines
Data Model
Curator Guide
Release Documentation
Computationally inferred events
FAQ
Linking to Us
Citing us
Tools
Pathway Browser
Analyse gene list
Analyse gene expression
Species Comparison
Tissue Distribution
Analysis Service
Content Service
ReactomeFIViz
Advanced Data Search
Site Search
Community
Contribute Pathway Knowledge
Icon Library
Outreach
Events
Publications
Partners
Contributors
Resources Guide
Download
Search ...
Go!
p-T32,S253,S315-FOXO3 [nucleoplasm]
Stable Identifier
R-HSA-199289
Type
Protein [EntityWithAccessionedSequence]
Species
Homo sapiens
Compartment
nucleoplasm
Synonyms
Phospho-Forkhead box protein O3A (T32, S253, S315), FOXO3_HUMAN, FOXO3A
Icon
Locations in the PathwayBrowser for interactor UniProt:Q92974 ARHGEF2
Expand all
Immune System (Homo sapiens)
Cytokine Signaling in Immune system (Homo sapiens)
FLT3 Signaling (Homo sapiens)
AKT phosphorylates FOXO3 downstream of FLT3 (Homo sapiens)
p-T32,S253,S315-FOXO3 [nucleoplasm] (Homo sapiens)
AKT-phosphorylated FOXO3 translocates to cytosol (Homo sapiens)
p-T32,S253,S315-FOXO3 [nucleoplasm] (Homo sapiens)
Signal Transduction (Homo sapiens)
Signaling by Nuclear Receptors (Homo sapiens)
ESR-mediated signaling (Homo sapiens)
Extra-nuclear estrogen signaling (Homo sapiens)
Estrogen-dependent nuclear events downstream of ESR-membrane signaling (Homo sapiens)
AKT phosphorylates FOXO3 downstream of ESR1 and EGFR (Homo sapiens)
p-T32,S253,S315-FOXO3 [nucleoplasm] (Homo sapiens)
AKT-phosphorylated FOXO3 translocates to cytosol (Homo sapiens)
p-T32,S253,S315-FOXO3 [nucleoplasm] (Homo sapiens)
External Reference Information
External Reference
UniProt:O43524 FOXO3
Gene Names
FOXO3, FKHRL1, FOXO3A
Chain
chain:1-673
Reference Genes
BioGPS Gene:2309 FOXO3
COSMIC (genes):FOXO3 FOXO3
CTD Gene:2309 FOXO3
dbSNP Gene:2309 FOXO3
ENSEMBL:ENSG00000118689 FOXO3
ENSEMBL_homo_sapiens_GENE:ENSG00000118689.15 FOXO3
HGNC:3821 FOXO3
KEGG Gene (Homo sapiens):2309 FOXO3
Monarch:2309 FOXO3
NCBI Gene:2309 FOXO3
OMIM:602681 FOXO3
UCSC:O43524 FOXO3
Reference Transcript
RefSeq:XM_005266868.3 FOXO3
RefSeq:XM_011535629.2 FOXO3
RefSeq:NM_201559.2 FOXO3
RefSeq:XM_011535628.2 FOXO3
RefSeq:NM_001455.3 FOXO3
RefSeq:XM_017010586.1 FOXO3
Other Identifiers
11718890_x_at
11718891_s_at
11718892_s_at
11737906_x_at
11746522_s_at
11746523_x_at
11749812_s_at
11755663_s_at
204131_PM_s_at
204131_s_at
204132_PM_s_at
204132_s_at
210655_PM_s_at
210655_s_at
217399_3p_s_at
217399_PM_s_at
217399_s_at
224889_3p_at
224889_PM_at
224889_at
224891_PM_at
224891_at
2309
2920476
2920477
2920478
2920479
2920480
2920481
2920482
2920483
2920484
2920485
2920486
2920537
2920538
2920541
2920542
2920543
2920556
2920567
2920568
2920570
2920572
2920574
2920575
34740_at
3748537
3748538
3748557
3748558
3748560
3748563
3748564
3748565
3748566
3748567
3748568
3748569
3748570
47893_s_at
49469_at
49651_at
8013307
8121365
A_23_P345575
A_32_P102062
A_33_P3240392
A_33_P3375665
GE54251
GE85764
GO:0000122
GO:0000785
GO:0000976
GO:0000978
GO:0000981
GO:0001221
GO:0001227
GO:0001228
GO:0001542
GO:0001544
GO:0001547
GO:0001556
GO:0002376
GO:0003012
GO:0003677
GO:0003700
GO:0005515
GO:0005634
GO:0005654
GO:0005694
GO:0005737
GO:0005739
GO:0005741
GO:0005759
GO:0005829
GO:0006351
GO:0006355
GO:0006357
GO:0006390
GO:0006417
GO:0006914
GO:0006915
GO:0007155
GO:0008013
GO:0009410
GO:0010508
GO:0012501
GO:0014737
GO:0016020
GO:0019901
GO:0022414
GO:0023052
GO:0030154
GO:0030330
GO:0030336
GO:0031490
GO:0031667
GO:0032991
GO:0033209
GO:0034246
GO:0034599
GO:0042149
GO:0042593
GO:0042594
GO:0043065
GO:0043226
GO:0043525
GO:0043565
GO:0045591
GO:0045648
GO:0045665
GO:0045893
GO:0045944
GO:0048854
GO:0048856
GO:0048870
GO:0060070
GO:0070542
GO:0071333
GO:0071386
GO:0071456
GO:0071548
GO:0090090
GO:0090571
GO:0097150
GO:0097192
GO:0140053
GO:0140110
GO:1901300
GO:1902895
GO:1903428
GO:1904646
GO:1990090
GO:1990785
GO:1990837
GO:2000177
GO:2000353
GO:2000377
HMNXSV003035668
Hs.14845.0.A2_3p_a_at
Hs.214783.0.S1_3p_at
Hs.214783.0.S1_3p_x_at
Hs.214783.0.S2_3p_at
Hs.274468.0.S1_3p_s_at
ILMN_1681703
ILMN_1687940
ILMN_1712515
ILMN_1844692
PH_hs_0028777
PH_hs_0033951
TC06000868.hg
TC06002977.hg
g4106722_3p_a_at
Participates
as an output of
AKT phosphorylates FOXO3 downstream of FLT3 (Homo sapiens)
AKT phosphorylates FOXO3 downstream of ESR1 and EGFR (Homo sapiens)
as an input of
AKT-phosphorylated FOXO3 translocates to cytosol (Homo sapiens)
AKT-phosphorylated FOXO3 translocates to cytosol (Homo sapiens)
as a member of
p-T24,S256,S319-FOXO1,p-T32,S253,S315-FOXO3,p-T32,S197,S262-FOXO4 [nucleoplasm] (Homo sapiens)
p-T24,S256,S319-FOXO1,p-T32,S253,S315-FOXO3,p-T32,S197,S262-FOXO4,(p-T26,S184-FOXO6) [nucleoplasm] (Homo sapiens)
Other forms of this molecule
p-S215 FOXO3 [nucleoplasm]
p-S215 FOXO3 [cytosol]
FOXO3 [cytosol]
p-S43,S173,S294,S325-FOXO3 [nucleoplasm]
p-S43,S173,S294,S325-FOXO3 [cytosol]
FOXO3(?-673) [mitochondrial matrix]
Ac-K271,K290-FOXO3(?-673) [mitochondrial matrix]
Ac-K242,K259,K271,K290,K569-FOXO3 [nucleoplasm]
p-T32,S253,S315-FOXO3 [cytosol]
FOXO3 [nucleoplasm]
Inferred To
phospho-Foxo3 [nucleoplasm]
(Mus musculus)
phospho-Foxo3 [nucleoplasm]
(Rattus norvegicus)
phospho-FOXO3 [nucleoplasm]
(Bos taurus)
phospho-FOXO3 [nucleoplasm]
(Canis familiaris)
phospho-FOXO3 [nucleoplasm]
(Gallus gallus)
phospho-FOXO3 [nucleoplasm]
(Sus scrofa)
phospho-foxo3 [nucleoplasm]
(Xenopus tropicalis)
phospho-foxo [nucleoplasm]
(Drosophila melanogaster)
phospho-foxo3b [nucleoplasm]
(Danio rerio)
phospho-daf-16 [nucleoplasm]
(Caenorhabditis elegans)
Modified Residues
Name
O-phospho-L-serine at 253
Coordinate
253
PsiMod Name
O-phospho-L-serine [MOD:00046]
PsiMod Definition
A protein modification that effectively converts an L-serine residue to O-phospho-L-serine.
Name
O-phospho-L-serine at 315
Coordinate
315
PsiMod Name
O-phospho-L-serine [MOD:00046]
PsiMod Definition
A protein modification that effectively converts an L-serine residue to O-phospho-L-serine.
Name
O-phospho-L-threonine at 32
Coordinate
32
PsiMod Name
O-phospho-L-threonine [MOD:00047]
PsiMod Definition
A protein modification that effectively converts an L-threonine residue to O-phospho-L-threonine.
Cross References
RefSeq
XP_016866075.1
,
XP_005266925.1
,
XP_011533931.1
,
NP_001446.1
,
NP_963853.1
,
XP_011533930.1
OpenTargets
ENSG00000118689
HPA
ENSG00000118689-FOXO3
GeneCards
O43524
Ensembl
ENSP00000446316
,
ENST00000406360
,
ENSP00000339527
,
ENSP00000385824
,
ENST00000343882
,
ENST00000540898
,
ENSG00000118689
PRO
O43524
Pharos - Targets
O43524
PDB
6MNL
,
7V9B
,
2UZK
,
2K86
,
2LQH
,
2LQI
Interactors (29)
Accession
#Entities
Entities
Confidence Score
Evidence (IntAct)
UniProt:P63104 YWHAZ
2
YWHAZ [nucleoplasm]
(R-HSA-450469)
YWHAZ [cytosol]
(R-HSA-206099)
0.851
6
UniProt:P31946 YWHAB
1
YWHAB [cytosol]
(R-HSA-48888)
0.774
6
UniProt:Q04917 YWHAH
1
YWHAH [cytosol]
(R-HSA-1445107)
0.774
6
UniProt:Q13485 SMAD4
20
SMAD4 P356R [cytosol]
(R-HSA-3310988)
SMAD4 K428T [cytosol]
(R-HSA-3311004)
SMAD4 D351del [cytosol]
(R-HSA-3310974)
SMAD4 R361H [cytosol]
(R-HSA-3310984)
SMAD4 P356L [cytosol]
(R-HSA-3310987)
SMAD4 A406T [cytosol]
(R-HSA-3311003)
SMAD4 D351Y [cytosol]
(R-HSA-3310970)
SMAD4 D351H [cytosol]
(R-HSA-3310965)
SMAD4 R361C [cytosol]
(R-HSA-3310983)
SMAD4 D351G [cytosol]
(R-HSA-3310967)
SMAD4 R515T [cytosol]
(R-HSA-3311008)
SMAD4 G352* [cytosol]
(R-HSA-9678445)
SMAD4 S178* [cytosol]
(R-HSA-9675630)
SMAD4 G477* [cytosol]
(R-HSA-9678447)
SMAD4 G473* [cytosol]
(R-HSA-9678440)
SMAD4 S144* [cytosol]
(R-HSA-9675625)
SMAD4 E538* [cytosol]
(R-HSA-9675626)
SMAD4 E390* [cytosol]
(R-HSA-9675620)
SMAD4 S154* [cytosol]
(R-HSA-9675621)
SMAD4 E330* [cytosol]
(R-HSA-9675622)
0.743
9
UniProt:P61981 YWHAG
1
YWHAG [cytosol]
(R-HSA-380312)
0.706
5
UniProt:Q96EB6 SIRT1
1
SIRT1 [nucleoplasm]
(R-HSA-427531)
0.704
5
UniProt:P62258 YWHAE
1
YWHAE [cytosol]
(R-HSA-194368)
0.695
5
UniProt:P31749 AKT1
14
p-T308,S473-AKT1 E17K [nucleoplasm]
(R-HSA-2399994)
p-T308,S473-AKT1 E17K [cytosol]
(R-HSA-2243935)
AKT1 E17K [cytosol]
(R-HSA-2219526)
p-S473-AKT1 E17K [plasma membrane]
(R-HSA-2243944)
AKT1 E17K [plasma membrane]
(R-HSA-1500573)
p-S473-AKT1 [cytosol]
(R-HSA-9841264)
p-T308,S473-AKT1 [plasma membrane]
(R-HSA-199430)
p-Y315,Y326-AKT1 [cytosol]
(R-HSA-8848757)
p-T308-AKT1 [cytosol]
(R-HSA-198634)
AKT1 [cytosol]
(R-HSA-58252)
AKT1 [plasma membrane]
(R-HSA-199416)
p-S473-AKT1 [plasma membrane]
(R-HSA-377265)
p-T308,S473-AKT1 [cytosol]
(R-HSA-198356)
p-T308,S473-AKT1 [nucleoplasm]
(R-HSA-198357)
0.692
3
UniProt:P84022 SMAD3
20
Ub-SMAD3 [cytosol]
(R-HSA-6782830)
p-S423,S425-SMAD3 D258N [cytosol]
(R-HSA-3315470)
p-S423,S425-SMAD3 R268C [cytosol]
(R-HSA-3315075)
p-S423,S425-SMAD3 R268H [cytosol]
(R-HSA-3315080)
SMAD3 Q316* [cytosol]
(R-HSA-9668765)
SMAD3 Y384* [cytosol]
(R-HSA-9668782)
SMAD3 W326* [cytosol]
(R-HSA-9668766)
SMAD3 E246* [cytosol]
(R-HSA-9668776)
SMAD3 Q358* [cytosol]
(R-HSA-9668772)
SMAD3 Q322* [cytosol]
(R-HSA-9668773)
SMAD3 S425F [cytosol]
(R-HSA-8944158)
SMAD3 E383* [cytosol]
(R-HSA-9668775)
SMAD3 R368* [cytosol]
(R-HSA-9668768)
SMAD3 Y298* [cytosol]
(R-HSA-9668769)
SMAD3 S425C [cytosol]
(R-HSA-3308499)
p-S208-SMAD3 [cytosol]
(R-HSA-9731114)
SMAD3 [nucleoplasm]
(R-HSA-206150)
2xADPRib-p-S423,S425-SMAD3 [nucleoplasm]
(R-HSA-2187326)
Ub,p-T179,S423,S425-SMAD3 [nucleoplasm]
(R-HSA-9773841)
p-T179,S423,S425-SMAD3 [nucleoplasm]
(R-HSA-2176471)
0.667
5
UniProt:P03372 ESR1
10
p-S118-ESR1 [nucleoplasm]
(R-HSA-9024210)
monoSUMO1-5K-ESR1 [nucleoplasm]
(R-HSA-4090302)
p-S167-ESR1 [nucleoplasm]
(R-HSA-9841867)
p-S167-ESR1 [cytosol]
(R-HSA-9841254)
Me260-ESR1 [cytosol]
(R-HSA-9632177)
PalmS-ESR1 [cytosol]
(R-HSA-9020974)
Me260-PalmS-ESR1 [plasma membrane]
(R-HSA-9637788)
PalmS-ESR1 [plasma membrane]
(R-HSA-9021057)
ESR1 [nucleoplasm]
(R-HSA-446168)
ESR1 [cytosol]
(R-HSA-9020968)
0.632
7
UniProt:P27348 YWHAQ
1
YWHAQ [cytosol]
(R-HSA-1445116)
0.615
3
UniProt:Q92731 ESR2
5
PalmS-ESR2 [cytosol]
(R-HSA-9020979)
Me-PalmS-ESR2 [plasma membrane]
(R-HSA-9637787)
PalmS-ESR2 [plasma membrane]
(R-HSA-9021059)
ESR2 [nucleoplasm]
(R-HSA-446165)
ESR2 [cytosol]
(R-HSA-9020970)
0.591
4
IntAct:EBI-1767788 BIM
0.59
2
UniProt:Q92793 CREBBP
4
monoSUMO1-K998,K1033,K1056-CREBBP [nucleoplasm]
(R-HSA-3927877)
FOXO4-S-S-CREBBP [nucleoplasm]
(R-HSA-9617684)
CREBBP [cytosol]
(R-HSA-9756493)
CREBBP [nucleoplasm]
(R-HSA-193545)
0.564
3
UniProt:Q60987 Foxg1
2
Foxg1 [nucleoplasm]
(R-MMU-9022630)
Foxg1 [nucleoplasm]
(R-MMU-9022629)
0.544
5
UniProt:P04637 TP53
20
Unfolded TP53 [cytosol]
(R-HSA-6813797)
TP53 [cytosol]
(R-HSA-8869337)
PolyUb-TP53 [nucleoplasm]
(R-HSA-6782509)
polySUMO2,3-K386-TP53 [nucleoplasm]
(R-HSA-2997661)
TP53 F341C [nucleoplasm]
(R-HSA-9726318)
TP53 G334V [nucleoplasm]
(R-HSA-9726126)
TP53 L330H [nucleoplasm]
(R-HSA-9726124)
TP53 A347T [nucleoplasm]
(R-HSA-9726339)
TP53 R337C [nucleoplasm]
(R-HSA-9726118)
TP53 L344P [nucleoplasm]
(R-HSA-9726075)
TP53 L344R [nucleoplasm]
(R-HSA-9726073)
TP53 R337H [nucleoplasm]
(R-HSA-9726169)
TP53 R337P [nucleoplasm]
(R-HSA-9726168)
TP53 L330P [nucleoplasm]
(R-HSA-9726136)
TP53 L348S [nucleoplasm]
(R-HSA-9726366)
TP53 R337L [nucleoplasm]
(R-HSA-9726163)
TP53 K351E [nucleoplasm]
(R-HSA-9726258)
TP53 F338I [nucleoplasm]
(R-HSA-9726358)
TP53 R342P [nucleoplasm]
(R-HSA-9726101)
TP53 L330R [nucleoplasm]
(R-HSA-9726133)
0.536
2
IntAct:EBI-1657542 ERALPHA
0.527
2
UniProt:P01106 MYC
2
PolyUb-MYC [nucleoplasm]
(R-HSA-6783169)
MYC [nucleoplasm]
(R-HSA-188379)
0.524
3
UniProt:P28749 RBL1
2
RBL1 [nucleoplasm]
(R-HSA-389104)
p-T369,S640,S964,S975-RBL1 [nucleoplasm]
(R-HSA-1226085)
0.499
3
UniProt:P30260 CDC27
2
CDC27 [nucleoplasm]
(R-HSA-174175)
CDC27 [cytosol]
(R-HSA-174073)
0.499
2
UniProt:P85037 FOXK1
1
FOXK1 [nucleoplasm]
(R-HSA-5689673)
0.499
2
UniProt:Q92974 ARHGEF2
1
ARHGEF2 [cytosol]
(R-HSA-195101)
0.499
2
UniProt:Q96T60 PNKP
1
PNKP [nucleoplasm]
(R-HSA-5649651)
0.499
2
UniProt:O75529 TAF5L
1
TAF5L [nucleoplasm]
(R-HSA-212336)
0.499
2
UniProt:P06400 RB1
20
RB1 R661W [nucleoplasm]
(R-HSA-9659801)
RB1 C706F [nucleoplasm]
(R-HSA-9659812)
RB1 N480del [nucleoplasm]
(R-HSA-9659792)
RB1 C706Y [nucleoplasm]
(R-HSA-9659821)
RB1 R661Q [nucleoplasm]
(R-HSA-9659807)
RB1 I703_E737del [nucleoplasm]
(R-HSA-9661065)
RB1 R830_G887del [cytosol]
(R-HSA-9661059)
RB1 K791* [cytosol]
(R-HSA-9662284)
RB1 Q176* [cytosol]
(R-HSA-9661774)
RB1 S114* [cytosol]
(R-HSA-9661775)
RB1 K765* [cytosol]
(R-HSA-9662281)
RB1 W99* [cytosol]
(R-HSA-9661769)
RB1 S149* [cytosol]
(R-HSA-9661770)
RB1 E166* [cytosol]
(R-HSA-9661767)
RB1 G100* [cytosol]
(R-HSA-9661763)
RB1 E125* [cytosol]
(R-HSA-9661784)
RB1 Q121* [cytosol]
(R-HSA-9661780)
RB1 E184* [cytosol]
(R-HSA-9661781)
RB1 E137* [cytosol]
(R-HSA-9661782)
RB1 K745* [cytosol]
(R-HSA-9662288)
0.499
2
UniProt:P31947 SFN
1
SFN [cytosol]
(R-HSA-1445105)
0.471
3
UniProt:P30153 PPP2R1A
2
PPP2R1A [nucleoplasm]
(R-HSA-165968)
PPP2R1A [cytosol]
(R-HSA-165982)
0.462
2
IntAct:EBI-2891650 CDKN1B
0.462
2
IntAct:EBI-2678752 ANDR
0.462
2
© 2024
Reactome
Cite Us!
Cite Us!
Cite Us!
Warning!
Unable to extract citation. Please try again later.
Download As:
BibTeX
RIS
Text