Phosphopantetheine conjugation of the ACP domain of FAS

Stable Identifier
R-HSA-199202
Type
Reaction [transition]
Species
Homo sapiens
Compartment
Synonyms
CoA-SH + FAS apoenzyme => adenosine 3',5'-bisphosphate + FAS holoenzyme
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Cytosolic AASDHPPT (alpha-aminoadipic semialdehyde dehydrogenase-phosphopantetheinyl transferase) catalyzes the transfer of a phosphopantetheine moiety from coenzyme A to serine 2156 within the ACP domain of FAS (fatty acyl synthase). Only a single human enzyme with phosphopantetheinyl transferase activity has been identified, and its broad substrate specificity suggests that it may be responsible as well for the postranslational modification of enzymes of lysine catabolism (Joshi et al. 2003; Praphanphoj et al. 2001).

Literature References
PubMed ID Title Journal Year
12815048 Cloning, expression, and characterization of a human 4'-phosphopantetheinyl transferase with broad substrate specificity

Joshi, AK, Zhang, L, Rangan, VS, Smith, S

J Biol Chem 2003
Participants
Participant Of
Catalyst Activity
Catalyst Activity
Title
holo-[acyl-carrier-protein] synthase activity of AASDHPPT [cytosol]
Physical Entity
Activity
Orthologous Events
Authored
Created