Reactome | MHC Class I interacts with CD160

MHC Class I interacts with CD160

Stable Identifier

R-HSA-199169

Type

Reaction [binding]

Species

Homo sapiens

Compartment

plasma membrane

ReviewStatus

5/5

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CD160 is a GPI-anchored lymphocyte surface receptor in which expression is mostly restricted to the highly cytotoxic NK cells. MHC class I molecules bind to CD160 receptors on circulating NK lymphocytes and this triggers their cytotoxic activity and cytokine production. NK cells stimulated by IL-15 secrete soluble CD160 protein that binds to MHC-I molecules, resulting in the inhibition of the cytotoxic CD8+ T lymphocyte activity and of the CD160-mediated NK cell cytotoxicity.

Literature References

PubMed ID	Title	Journal	Year
17237375	A soluble form of the MHC class I-specific CD160 receptor is released from human activated NK lymphocytes and inhibits cell-mediated cytotoxicity Bensussan, A, Marie-Cardine, A, Giustiniani, J	J Immunol	2007
16129954	HLA class I/NK cell receptor interaction in early human decidua basalis: possible functional consequences Strbo, N, Polgar, B, Berrebi, A, Bensussan, A, Tabiasco, J, Rukavina, D, Rabot, M, Aguerre-Girr, M, Le Bouteiller, P	Chem Immunol Allergy	2005