Reactome | CD200 binds to CD200R

CD200 binds to CD200R

Stable Identifier

R-HSA-199154

Type

Reaction [binding]

Species

Homo sapiens

Compartment

plasma membrane

ReviewStatus

5/5

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While not ubiquitously distributed, CD200 is expressed on a wide range of cell types including thymocytes, B-cells, activated T-cells, follicular dendritic cells, endothelium, CNS neurons in the central nervous system, cells in reproductive organs, keratinocytes and renal glomeruli. CD200R is a myeloid-inhibitory receptor, despite the absence of classical ITIMs in the cytoplasmic portion of the protein. Interestingly, CD200 is also expressed on neurons within the CNS and would be predicted to modulate activation of microglia through CD200R.

Literature References

PubMed ID	Title	Journal	Year
15187158	CD200 is a ligand for all members of the CD200R family of immunoregulatory molecules Gorczynski, R, Chen, Z, Kai, Y, Lee, L, Wong, S, Marsden, PA	J Immunol	2004
16928187	Is the CD200/CD200 receptor interaction more than just a myeloid cell inhibitory signal? Minas, K, Liversidge, J	Crit Rev Immunol	2006