Reactome | FABP1 [nucleoplasm]

FABP1 [nucleoplasm]

Stable Identifier

R-HSA-1989743

Type

Protein [EntityWithAccessionedSequence]

Species

Homo sapiens

Compartment

nucleoplasm

Synonyms

Fatty acid-binding protein, liver, FABPL_HUMAN

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General

As inferred from mouse, FABP1 localizes to the nucleus where it may deliver lipids to PPARA.

Literature References

PubMed ID	Title	Journal	Year
11226238	Fatty acids and hypolipidemic drugs regulate peroxisome proliferator-activated receptors alpha - and gamma-mediated gene expression via liver fatty acid binding protein: a signaling path to the nucleus Borrmann, CM, Wolfrum, C, Borchers, T, Spener, F	Proc Natl Acad Sci U S A	2001
19289416	L-FABP directly interacts with PPARalpha in cultured primary hepatocytes Payne, HR, Storey, SM, Hostetler, HA, Schroeder, F, Kier, AB, McIntosh, AL, Atshaves, BP	J Lipid Res	2009

External Reference Information

External Reference

UniProt:P07148 FABP1

Gene Names

FABP1, FABPL

Chain

chain:1-127

Reference Genes

BioGPS Gene:2168 FABP1

COSMIC (genes):FABP1 FABP1

CTD Gene:2168 FABP1

dbSNP Gene:2168 FABP1

ENSEMBL:ENSG00000163586.10 FABP1

HGNC:3555 FABP1

KEGG Gene (Homo sapiens):2168 FABP1

Monarch:2168 FABP1

NCBI Gene:2168 FABP1

OMIM:134650 FABP1

Reference Transcript

RefSeq:NM_001443.2 FABP1

Other Identifiers

0006550025

11723040_a_at

11723041_s_at

11758878_x_at

16900030

205892_PM_s_at

205892_s_at

2168

2563539

2563540

2563546

2563548

2563554

2563555

38586_at

8053654

A_23_P79562

GE81021

GO:0003682

GO:0005215

GO:0005324

GO:0005504

GO:0005515

GO:0005543

GO:0005576

GO:0005615

GO:0005622

GO:0005634

GO:0005654

GO:0005737

GO:0005777

GO:0005782

GO:0005829

GO:0006629

GO:0008289

GO:0012501

GO:0015908

GO:0015909

GO:0016209

GO:0022600

GO:0032000

GO:0032052

GO:0032991

GO:0043066

GO:0043154

GO:0043226

GO:0045179

GO:0050892

GO:0051345

GO:0070062

GO:0070301

GO:0070538

GO:0071456

GO:0098754

GO:0098869

GO:1901363

HMNXSV003007276

ILMN_1678965

ILMN_1772328

M10050_at

PH_hs_0018467

TC02002069.hg

TC02004392.hg

g4557576_3p_at

g4557576_3p_s_at

Participates

as an output of

as a component of

FABP1:ligands of PPARA [nucleoplasm] (Homo sapiens)

Other forms of this molecule

FABP1 [cytosol]

Inferred To

Fabp1 [nucleoplasm] (Mus musculus)

LFABP [nucleoplasm] (Gallus gallus)

fabp [nucleoplasm] (Drosophila melanogaster)

fabp1b.1 [nucleoplasm] (Danio rerio)

FABP1 [nucleoplasm] (Bos taurus)

FABP1 [nucleoplasm] (Canis familiaris)

FABP1 [nucleoplasm] (Rattus norvegicus)

Cross References

RefSeq

NP_001434.1

Guide to Pharmacology - Targets

2531

OpenTargets

ENSG00000163586

GeneCards

P07148

HPA

ENSG00000163586-FABP1

Ensembl

ENSG00000163586, ENST00000295834, ENSP00000295834

ZINC target

P07148

PRO

P07148

Pharos - Targets

P07148

PDB

3STN, 3B2L, 6DRG, 2L67, 3VG3, 3B2H, 6MP4, 3VG6, 3VG7, 3STM, 3VG2, 3B2K, 2LKK, 3B2I, 3STK, 2PY1, 2F73, 3B2J, 3VG4, 6DO6, 3VG5, 2L68, 6DO7

Interactors (2)

Accession	#Entities	Entities	Confidence Score	Evidence (IntAct)
UniProt:P21333-2 FLNA			0.556	3
UniProt:FLNA Q5HY54			0.556	3