SLC2A1,3 transports DeHA from extracellular region to cytosol

Stable Identifier
Reaction [transition]
Homo sapiens
Dehydroascorbate transport across the plasma membrane, dehydroascorbate [extracellular] => dehydroascorbate [cytosol]
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The uptake of extracellular dehydroascorbate (DeHA) into the cytosol is mediated by GLUT1 and GLUT3 (encoded by SLC2A1 and SLCA3 respectively) associated with the plasma membrane (Rumsey et al. 1997, 2000). This process may play a significant role in ascorbate utilization in the central nervous system (Agus et al. 1997). The process is efficiently competitively inhibited by glucose, leading to the suggestion that inhibited dehydroascorbate uptake may contribute to the pathology of diabetes (Liang et al. 2001, Rumsey et al. 2000).

Literature References
PubMed ID Title Journal Year
10862609 Dehydroascorbic acid transport by GLUT4 in Xenopus oocytes and isolated rat adipocytes

Rumsey, SC, Daruwala, R, Levine, M, Simpson, I, Zarnowski, MJ, Al-Hasani, H

J Biol Chem 2000
9228080 Glucose transporter isoforms GLUT1 and GLUT3 transport dehydroascorbic acid

Rumsey, SC, Burant, CF, Levine, M, Simpson, I, Xu, GW, Kwon, O

J Biol Chem 1997
Catalyst Activity

dehydroascorbic acid transmembrane transporter activity of SLC2A1,3 [plasma membrane]

Orthologous Events
Cross References
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