SLC2A1,3 transports DeHA from extracellular region to cytosol

Stable Identifier
R-HSA-198818
Type
Reaction [transition]
Species
Homo sapiens
Compartment
Synonyms
Dehydroascorbate transport across the plasma membrane, dehydroascorbate [extracellular] => dehydroascorbate [cytosol]
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The uptake of extracellular dehydroascorbate (DeHA) into the cytosol is mediated by GLUT1 and GLUT3 (encoded by SLC2A1 and SLCA3 respectively) associated with the plasma membrane (Rumsey et al. 1997, 2000). This process may play a significant role in ascorbate utilization in the central nervous system (Agus et al. 1997). The process is efficiently competitively inhibited by glucose, leading to the suggestion that inhibited dehydroascorbate uptake may contribute to the pathology of diabetes (Liang et al. 2001, Rumsey et al. 2000).

Literature References
PubMed ID Title Journal Year
9228080 Glucose transporter isoforms GLUT1 and GLUT3 transport dehydroascorbic acid

Rumsey, SC, Kwon, O, Xu, GW, Burant, CF, Simpson, I, Levine, M

J Biol Chem 1997
10862609 Dehydroascorbic acid transport by GLUT4 in Xenopus oocytes and isolated rat adipocytes

Rumsey, SC, Daruwala, R, Al-Hasani, H, Zarnowski, MJ, Simpson, I, Levine, M

J Biol Chem 2000
Participants
Participant Of
Catalyst Activity
Catalyst Activity
Title
dehydroascorbic acid transmembrane transporter activity of SLC2A1,3 [plasma membrane]
Physical Entity
Activity
Orthologous Events
Cross References
Rhea
Authored
Created