Reactome | SLC2A1,3 transports DeHA from extracellular region to cytosol

SLC2A1,3 transports DeHA from extracellular region to cytosol

Stable Identifier

R-HSA-198818

Type

Reaction [transition]

Species

Homo sapiens

Compartment

plasma membrane

Synonyms

Dehydroascorbate transport across the plasma membrane, dehydroascorbate [extracellular] => dehydroascorbate [cytosol]

ReviewStatus

5/5

Locations in the PathwayBrowser

Expand all

General

SBML | | PDF

SVG | | PPTX | SBGN

SLC2A1,3 transports DeHA from extracellular region to cytosol

Click the image above or here to open this reaction in the Pathway Browser
The layout of this reaction may differ from that in the pathway view due to the constraints in pathway layout

The uptake of extracellular dehydroascorbate (DeHA) into the cytosol is mediated by GLUT1 and GLUT3 (encoded by SLC2A1 and SLCA3 respectively) associated with the plasma membrane (Rumsey et al. 1997, 2000). This process may play a significant role in ascorbate utilization in the central nervous system (Agus et al. 1997). The process is efficiently competitively inhibited by glucose, leading to the suggestion that inhibited dehydroascorbate uptake may contribute to the pathology of diabetes (Liang et al. 2001, Rumsey et al. 2000).

Literature References

PubMed ID	Title	Journal	Year
10862609	Dehydroascorbic acid transport by GLUT4 in Xenopus oocytes and isolated rat adipocytes Rumsey, SC, Daruwala, R, Levine, M, Simpson, I, Zarnowski, MJ, Al-Hasani, H	J Biol Chem	2000
9228080	Glucose transporter isoforms GLUT1 and GLUT3 transport dehydroascorbic acid Rumsey, SC, Burant, CF, Levine, M, Simpson, I, Xu, GW, Kwon, O	J Biol Chem	1997