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Nuclear Events (kinase and transcription factor activation)
Stable Identifier
R-HSA-198725
DOI
10.3180/REACT_12433.1
Type
Pathway
Species
Homo sapiens
ReviewStatus
5/5
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Signal Transduction (Homo sapiens)
Signaling by Receptor Tyrosine Kinases (Homo sapiens)
Signaling by NTRKs (Homo sapiens)
Signaling by NTRK1 (TRKA) (Homo sapiens)
Nuclear Events (kinase and transcription factor activation) (Homo sapiens)
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An important function of the kinase cascade triggered by neurotrophins is to induce the phosphorylation and activation of transcription factors in the nucleus to initiate new programs of gene expression. Transcription factors directly activated by neurotrophin signalling are responsible for induction of immediate-early genes, many of which are transcription factors. These in turn are involved in the induction of delayed-early genes.
Literature References
PubMed ID
Title
Journal
Year
8833451
Intracellular signaling pathways activated by neurotrophic factors
Segal, RA
,
Greenberg, ME
Annu Rev Neurosci
1996
Participants
Events
ERK/MAPK targets
(Homo sapiens)
CREB phosphorylation
(Homo sapiens)
NGF-stimulated transcription
(Homo sapiens)
Participates
as an event of
Signaling by NTRK1 (TRKA) (Homo sapiens)
Orthologous Events
Nuclear Events (kinase and transcription factor activation) (Bos taurus)
Nuclear Events (kinase and transcription factor activation) (Caenorhabditis elegans)
Nuclear Events (kinase and transcription factor activation) (Canis familiaris)
Nuclear Events (kinase and transcription factor activation) (Danio rerio)
Nuclear Events (kinase and transcription factor activation) (Dictyostelium discoideum)
Nuclear Events (kinase and transcription factor activation) (Drosophila melanogaster)
Nuclear Events (kinase and transcription factor activation) (Gallus gallus)
Nuclear Events (kinase and transcription factor activation) (Mus musculus)
Nuclear Events (kinase and transcription factor activation) (Plasmodium falciparum)
Nuclear Events (kinase and transcription factor activation) (Rattus norvegicus)
Nuclear Events (kinase and transcription factor activation) (Saccharomyces cerevisiae)
Nuclear Events (kinase and transcription factor activation) (Schizosaccharomyces pombe)
Nuclear Events (kinase and transcription factor activation) (Sus scrofa)
Nuclear Events (kinase and transcription factor activation) (Xenopus tropicalis)
Authored
Nasi, S (2006-10-10)
Annibali, D (2006-10-10)
Reviewed
Greene, LA (2007-11-08)
Created
© 2025
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