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p-T23-CHUK [cytosol]
Stable Identifier
R-HSA-198615
Type
Protein [EntityWithAccessionedSequence]
Species
Homo sapiens
Compartment
cytosol
Synonyms
p-T23-IKKA, p-T23-IKK1, Phospho-IKK1 (T23)
Icon
Locations in the PathwayBrowser for interactor UniProt:Q9ULZ3 PYCARD
Expand all
Disease (Homo sapiens)
Diseases of signal transduction by growth factor receptors and second messengers (Homo sapiens)
PI3K/AKT Signaling in Cancer (Homo sapiens)
Constitutive Signaling by AKT1 E17K in Cancer (Homo sapiens)
AKT1 E17K mutant phosphorylates CHUK (IKKalpha) (Homo sapiens)
p-T23-CHUK [cytosol] (Homo sapiens)
Signal Transduction (Homo sapiens)
Intracellular signaling by second messengers (Homo sapiens)
PIP3 activates AKT signaling (Homo sapiens)
AKT phosphorylates targets in the cytosol (Homo sapiens)
AKT phosphorylates IKKalpha (Homo sapiens)
p-T23-CHUK [cytosol] (Homo sapiens)
External Reference Information
External Reference
UniProt:O15111 CHUK
Gene Names
CHUK, IKKA, TCF16
Chain
chain:1-745
Reference Genes
BioGPS Gene:1147 CHUK
COSMIC (genes):CHUK CHUK
CTD Gene:1147 CHUK
dbSNP Gene:1147 CHUK
ENSEMBL:ENSG00000213341 CHUK
ENSEMBL_homo_sapiens_GENE:ENSG00000213341.11 CHUK
HGNC:1974 CHUK
KEGG Gene (Homo sapiens):1147 CHUK
Monarch:1147 CHUK
NCBI Gene:1147 CHUK
OMIM:600664 CHUK
UCSC:O15111 CHUK
Reference Transcript
RefSeq:NM_001278.4 CHUK
Other Identifiers
1147
11754797_a_at
16717469
209666_PM_s_at
209666_s_at
3303298
3303299
3303301
3303302
3303304
3303309
3303310
3303312
3303314
3303315
3303320
3303321
3303322
3303324
3303325
3303326
3303327
3303328
3303329
3303330
3303331
3303332
3303333
3303334
3303335
3303336
3303337
3303338
33770_at
7935707
A_23_P46748
A_33_P3258141
GE62511
GE81000
GO:0000166
GO:0002376
GO:0003009
GO:0003012
GO:0003824
GO:0004672
GO:0004674
GO:0005515
GO:0005524
GO:0005634
GO:0005654
GO:0005737
GO:0005829
GO:0005886
GO:0006351
GO:0006355
GO:0006468
GO:0006954
GO:0006955
GO:0007249
GO:0007252
GO:0007266
GO:0008384
GO:0008385
GO:0009410
GO:0009615
GO:0009636
GO:0009653
GO:0009898
GO:0009967
GO:0010033
GO:0010034
GO:0010628
GO:0016301
GO:0016310
GO:0016740
GO:0023052
GO:0030154
GO:0032088
GO:0032496
GO:0032727
GO:0033194
GO:0033209
GO:0034142
GO:0034614
GO:0035631
GO:0036211
GO:0038061
GO:0042803
GO:0043123
GO:0043200
GO:0043226
GO:0044877
GO:0045087
GO:0045893
GO:0045944
GO:0046982
GO:0048856
GO:0050877
GO:0050896
GO:0051092
GO:0051146
GO:0061847
GO:0071276
GO:0071356
GO:0097110
GO:0098542
GO:0098586
GO:0140096
GO:1990459
HMNXSV003015828
ILMN_1677041
PH_hs_0011697
TC10002931.hg
g4185272_3p_s_at
Participates
as an output of
AKT1 E17K mutant phosphorylates CHUK (IKKalpha) (Homo sapiens)
AKT phosphorylates IKKalpha (Homo sapiens)
Other forms of this molecule
CHUK [cytosol]
p-S176,S180-CHUK [cytosol]
p-Y187,Y198-CHUK [cytosol]
Inferred To
phospho-p-T23-CHUK [cytosol]
(Bos taurus)
phospho-p-T23-CHUK [cytosol]
(Danio rerio)
phospho-p-T23-CHUK [cytosol]
(Drosophila melanogaster)
phospho-p-T23-CHUK [cytosol]
(Gallus gallus)
phospho-p-T23-CHUK [cytosol]
(Mus musculus)
phospho-p-T23-CHUK [cytosol]
(Rattus norvegicus)
phospho-p-T23-CHUK [cytosol]
(Sus scrofa)
phospho-p-T23-CHUK [cytosol]
(Xenopus tropicalis)
phospho-CHUK [cytosol]
(Canis familiaris)
Modified Residues
Name
O-phospho-L-threonine at 23
Coordinate
23
PsiMod Name
O-phospho-L-threonine [MOD:00047]
PsiMod Definition
A protein modification that effectively converts an L-threonine residue to O-phospho-L-threonine.
Cross References
RefSeq
NP_001269.3
ZINC - World Drugs
IKKA_HUMAN
Guide to Pharmacology - Targets
1989
OpenTargets
ENSG00000213341
ZINC - FDA approved
IKKA_HUMAN
ZINC - Substances
IKKA_HUMAN
ZINC - Biogenic
IKKA_HUMAN
ZINC target
O15111
PRO
O15111
PDB
5TQX
,
3BRT
,
5EBZ
,
5TQY
,
5TQW
ZINC - Investigational
IKKA_HUMAN
IntEnz
2.7.11.10
GeneCards
O15111
HPA
ENSG00000213341-CHUK
Ensembl
ENSG00000213341
,
ENST00000370397
,
ENSP00000359424
Pharos - Targets
O15111
Orphanet
24278
ZINC - Predictions - Purchasable
IKKA_HUMAN
HMDB Protein
HMDBP02038
Interactors (25)
Accession
#Entities
Entities
Confidence Score
Evidence (IntAct)
UniProt:Q9Y6K9 IKBKG
12
IKBKG D406V [cytosol]
(R-HSA-5262943)
IKBKG L153R [cytosol]
(R-HSA-5262879)
IKBKG E391* [cytosol]
(R-HSA-5262924)
IKBKG C417R [cytosol]
(R-HSA-5262858)
IKBKG R173G [cytosol]
(R-HSA-5262966)
IKBKG R175P [cytosol]
(R-HSA-5262916)
IKBKG *420Wext*447 [cytosol]
(R-HSA-5262978)
monoSUMO1-K277,K309-IKBKG [nucleoplasm]
(R-HSA-4755449)
IKBKG [nucleoplasm]
(R-HSA-4755413)
K63polyUb-IKBKG [cytosol]
(R-HSA-202530)
Ub-285-IKBKG [cytosol]
(R-HSA-741397)
IKBKG [cytosol]
(R-HSA-168108)
0.972
31
UniProt:O14920 IKBKB
3
IKBKB Q432Pfs*62 [cytosol]
(R-HSA-9628518)
IKBKB [cytosol]
(R-HSA-168114)
p-S177,S181-IKBKB [cytosol]
(R-HSA-202506)
0.956
21
UniProt:P25963 NFKBIA
9
PolyUb-NFKBIA [cytosol]
(R-HSA-6782960)
NFKBIA [cytosol]
(R-HSA-168151)
p-S32,S36-NFKBIA [cytosol]
(R-HSA-177677)
Ub-K21,22-p-S32,S36-NFKBIA [cytosol]
(R-HSA-1168581)
NFKBIA [nucleoplasm]
(R-HSA-4656929)
monoSUMO1-K21-NFKBIA [nucleoplasm]
(R-HSA-4656935)
NFKBIA S32I [cytosol]
(R-HSA-5228846)
NFKBIA F2_M37del [cytosol]
(R-HSA-9630119)
NFKBIA M37K [cytosol]
(R-HSA-5228805)
0.954
16
UniProt:Q99558 MAP3K14
5
p-T559-MAP3K14 [cytosol]
(R-HSA-5668531)
K48polyUb-NIK [cytosol]
(R-HSA-5668525)
Active NIK [cytosol]
(R-HSA-5607646)
MAP3K14 [cytosol]
(R-HSA-168189)
p-MAP3K14 [cytosol]
(R-HSA-168187)
0.946
14
UniProt:Q16543 CDC37
1
CDC37 [cytosol]
(R-HSA-1221609)
0.886
9
UniProt:Q13451 FKBP5
2
FKBP5 [cytosol]
(R-HSA-5618096)
FKBP5 [nucleoplasm]
(R-HSA-8939165)
0.784
6
UniProt:P19838 NFKB1
8
NFKB1(1-968) [specific granule lumen]
(R-HSA-6799557)
NFKB1(1-968) [extracellular region]
(R-HSA-6806304)
NFKB1(1-968) [secretory granule lumen]
(R-HSA-6801004)
NFKB1(1-433) [cytosol]
(R-HSA-168168)
NFKB1(1-433) [nucleoplasm]
(R-HSA-177655)
NFKB1(1-968) [cytosol]
(R-HSA-451607)
p-S927,S932-NFKB1(1-968) [cytosol]
(R-HSA-451611)
3xUb-p-S927,S932-NFKB1(1-968) [cytosol]
(R-HSA-451619)
0.779
4
UniProt:Q04206 RELA
7
MeK310-RELA [nucleoplasm]
(R-HSA-8865233)
p-S536-RELA [nucleoplasm]
(R-HSA-9861499)
p-S276,5xAcK-RELA [nucleoplasm]
(R-HSA-5660642)
p-S276-RELA [nucleoplasm]
(R-HSA-5624468)
polySUMO3-K37,K122,K123-RELA [nucleoplasm]
(R-HSA-4755466)
RELA [cytosol]
(R-HSA-168172)
RELA [nucleoplasm]
(R-HSA-177676)
0.669
3
UniProt:P07900 HSP90AA1
8
HSP90AA1 [secretory granule lumen]
(R-HSA-6801515)
HSP90AA1 [ficolin-1-rich granule lumen]
(R-HSA-6801470)
HSP90AA1 [plasma membrane]
(R-HSA-534996)
HSP90AA1 [endocytic vesicle lumen]
(R-HSA-3221912)
HSP90AA1 [extracellular region]
(R-HSA-3221946)
HSP90AA1 [nucleoplasm]
(R-HSA-5082401)
HSP90AA1 [cytosol]
(R-HSA-192864)
HSP90AA1 [lysosomal lumen]
(R-HSA-9622850)
0.669
4
UniProt:O43318 MAP3K7
10
PolyUb-MAP3K7 [cytosol]
(R-HSA-6782968)
MAP3K7 [plasma membrane]
(R-HSA-9012677)
K63polyUb-34,158-p-T178,184,187,S192-TAK1 [cytosol]
(R-HSA-5607649)
K63polyUb-34,158-TAK1 [cytosol]
(R-HSA-5607643)
p-MAP3K7 [cytosol]
(R-HSA-168163)
p-T187-MAP3K7 [cytosol]
(R-HSA-206014)
MAP3K7 [endosome membrane]
(R-HSA-450315)
p-T184,T187-MAP3K7 [endosome membrane]
(R-HSA-450332)
MAP3K7 [cytosol]
(R-HSA-168156)
p-T184,T187-MAP3K7 [cytosol]
(R-HSA-202527)
0.65
3
UniProt:P24772 PG200
0.623
3
UniProt:O15111 CHUK
4
CHUK [cytosol]
(R-HSA-168104)
p-S176,S180-CHUK [cytosol]
(R-HSA-177667)
p-T23-CHUK [cytosol]
(R-HSA-198615)
p-Y187,Y198-CHUK [cytosol]
(R-HSA-9861501)
0.609
2
UniProt:Q15653 NFKBIB
3
p-S19,S23-Ub-NFKBIB [cytosol]
(R-HSA-1168571)
p-S19,S23-NFKBIB [cytosol]
(R-HSA-177670)
NFKBIB [cytosol]
(R-HSA-168132)
0.564
3
UniProt:Q7Z406 MYH14
1
MYH14 [cytosol]
(R-HSA-419176)
0.564
2
UniProt:P08238 HSP90AB1
6
HSP90AB1 [secretory granule lumen]
(R-HSA-6801477)
HSP90AB1 [extracellular region]
(R-HSA-6806463)
HSP90AB1 [ficolin-1-rich granule lumen]
(R-HSA-6801491)
HSP90AB1 [cytosol]
(R-HSA-419617)
HSP90AB1 [nucleoplasm]
(R-HSA-5082399)
HSP90AB1 [lysosomal lumen]
(R-HSA-9622846)
0.564
3
UniProt:Q86VP1 TAX1BP1
1
TAX1BP1 [cytosol]
(R-HSA-937346)
0.544
2
UniProt:Q99759 MAP3K3
1
MAP3K3 [cytosol]
(R-HSA-507725)
0.536
2
UniProt:Q6ZSG2 INSY2
0.527
2
UniProt:Q86WI3 NLRC5
2
K63polyUb-NLRC5 [cytosol]
(R-HSA-9750938)
NLRC5 [cytosol]
(R-HSA-937324)
0.524
3
UniProt:Q5TCX8 M3K21
0.524
2
UniProt:Q15796 SMAD2
20
Ub-SMAD2 [cytosol]
(R-HSA-6782774)
p-S465,S467-SMAD2 P305L [cytosol]
(R-HSA-3315471)
p-S465,S467-SMAD2 D300A [cytosol]
(R-HSA-3315064)
p-S465,S467-SMAD2 D300N [cytosol]
(R-HSA-3315066)
p-S465,S467-SMAD2 A354T [cytosol]
(R-HSA-3315474)
p-S465,S467-SMAD2 P305Q [cytosol]
(R-HSA-3315070)
p-S465,S467-SMAD2 D300V [cytosol]
(R-HSA-3315067)
SMAD2 S464* [cytosol]
(R-HSA-3304362)
SMAD2 W422* [cytosol]
(R-HSA-9668736)
SMAD2 S308* [cytosol]
(R-HSA-9668732)
SMAD2 R427* [cytosol]
(R-HSA-9668733)
SMAD2 W448* [cytosol]
(R-HSA-9668734)
SMAD2 S464L [cytosol]
(R-HSA-3304383)
SMAD2 C463* [cytosol]
(R-HSA-9668735)
SMAD2 R321* [cytosol]
(R-HSA-9668728)
SMAD2 S296* [cytosol]
(R-HSA-9668729)
SMAD2 S306* [cytosol]
(R-HSA-9668730)
SMAD2 Q455* [cytosol]
(R-HSA-9668731)
SMAD2 E439* [cytosol]
(R-HSA-9668724)
SMAD2 L315* [cytosol]
(R-HSA-9668725)
0.524
2
UniProt:Q9ULZ3 PYCARD
4
PYCARD [cytosol]
(R-HSA-561191)
PYCARD [azurophil granule lumen]
(R-HSA-6798768)
PYCARD [extracellular region]
(R-HSA-6806196)
PYCARD [secretory granule lumen]
(R-HSA-6800957)
0.512
5
UniProt:P71451 INLC
0.509
3
UniProt:P32121 ARRB2
3
ARRB2 [cytosol]
(R-HSA-416464)
PolyUb-ARRB2 [cytosol]
(R-HSA-6783000)
ARRB2 [endocytic vesicle membrane]
(R-HSA-9910881)
0.483
3
UniProt:P01106 MYC
2
PolyUb-MYC [nucleoplasm]
(R-HSA-6783169)
MYC [nucleoplasm]
(R-HSA-188379)
0.463
3
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