Cytosolic MDH1 (malate dehydrogenase 1) catalyzes the reaction of malate (MAL) and NAD+ to form oxaloacetate (OA) and NADH + H+ (Friedrich et al. 1988; Lo et al. 2005). The dimeric structure of the human dehydrogenase is inferred from that established for its well-studied pig homolog (Birktoft et al. 1989).
Friedrich, CA, Kitto, GB, Ferrell, RE, Siciliano, MJ
Rhodes, G, Banaszak, LJ, Birktoft, JJ
Liew, C-T, Waye, MM-Y, Lee, C-Y, Tsui, SK-W, Lo, AS-Y, Ngai, S-M, Fung, K-P
L-malate dehydrogenase activity of MDH1 dimer [cytosol]
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