malate + NAD+ <=> oxaloacetate + NADH + H+

Stable Identifier
R-HSA-198508
Type
Reaction [transition]
Species
Homo sapiens
Compartment
Synonyms
(S)-malate + NAD+ <=> oxaloacetate + NADH + H+
Locations in the PathwayBrowser
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Cytosolic malate dehydrogenase catalyzes the reaction of malate and NAD+ to form oxaloacetate and NADH + H+ (Lo et al. 2005). The dimeric structure of the human dehydrogenase is inferred from that established for its well-studied pig homolog (Birktoft et al. 1989).

Literature References
PubMed ID Title Journal Year
15565635 Developmental regulation and cellular distribution of human cytosolic malate dehydrogenase (MDH1)

Lo, AS-Y, Liew, C-T, Ngai, S-M, Tsui, SK-W, Fung, K-P, Lee, C-Y, Waye, MM-Y

J Cell Biochem 2005
Participants
Participant Of
hasEvent
Catalyst Activity
Catalyst Activity
Title
L-malate dehydrogenase activity of malate dehydrogenase 1 dimer [cytosol]
Physical Entity
Activity
Orthologous Events
Cross References
Rhea
Authored
Reviewed
Created