MDH1 oxidizes MAL to OA

Stable Identifier
R-HSA-198508
Type
Reaction [transition]
Species
Homo sapiens
Compartment
Synonyms
(S)-malate + NAD(+) => H(+) + NADH + oxaloacetate
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Cytosolic MDH1 (malate dehydrogenase 1) catalyzes the reaction of malate (MAL) and NAD+ to form oxaloacetate (OA) and NADH + H+ (Friedrich et al. 1988; Lo et al. 2005). The dimeric structure of the human dehydrogenase is inferred from that established for its well-studied pig homolog (Birktoft et al. 1989).

Literature References
PubMed ID Title Journal Year
3052244 Biochemical and genetic identity of alpha-keto acid reductase and cytoplasmic malate dehydrogenase from human erythrocytes

Friedrich, CA, Kitto, GB, Ferrell, RE, Siciliano, MJ

Ann Hum Genet 1988
2775751 Refined crystal structure of cytoplasmic malate dehydrogenase at 2.5-A resolution

Rhodes, G, Banaszak, LJ, Birktoft, JJ

Biochemistry 1989
15565635 Developmental regulation and cellular distribution of human cytosolic malate dehydrogenase (MDH1)

Liew, C-T, Waye, MM-Y, Lee, C-Y, Tsui, SK-W, Lo, AS-Y, Ngai, S-M, Fung, K-P

J Cell Biochem 2005
Participants
Participates
Catalyst Activity

L-malate dehydrogenase activity of MDH1 dimer [cytosol]

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