AKT phosphorylates GSK3

Stable Identifier
R-HSA-198371
Type
Reaction [transition]
Species
Homo sapiens
Compartment
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GSK3 (glycogen synthase kinase-3) participates in the Wnt signaling pathway. It is implicated in the hormonal control of several regulatory proteins including glycogen synthase, and the transcription factors MYB and JUN. GSK3 phosphorylates JUN at sites proximal to its DNA-binding domain, thereby reducing its affinity for DNA. GSK3 is inhibited when phosphorylated by AKT1.

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Participant Of
Event Information
Go Biological Process
Catalyst Activity
Catalyst Activity
Title
protein serine/threonine kinase activity of p-T,p-S-AKT [cytosol]
Physical Entity
Activity
Inferred From
Authored
Reviewed
Created