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p-S99-BAD [cytosol]
Stable Identifier
R-HSA-198335
Type
Protein [EntityWithAccessionedSequence]
Species
Homo sapiens
Compartment
cytosol
Synonyms
Phospho-BAD protein (at S99)
Locations in the PathwayBrowser for interactor UniProt:O43521 BCL2L11
Expand all
Disease (Homo sapiens)
Diseases of signal transduction (Homo sapiens)
PI3K/AKT Signaling in Cancer (Homo sapiens)
Constitutive Signaling by AKT1 E17K in Cancer (Homo sapiens)
AKT1 E17K mutant phosphorylates BAD (Homo sapiens)
p-S99-BAD [cytosol] (Homo sapiens)
Programmed Cell Death (Homo sapiens)
Apoptosis (Homo sapiens)
Intrinsic Pathway for Apoptosis (Homo sapiens)
Activation of BH3-only proteins (Homo sapiens)
Activation of BAD and translocation to mitochondria (Homo sapiens)
AKT phosphorylates BAD (Homo sapiens)
p-S99-BAD [cytosol] (Homo sapiens)
Sequestration of BAD protein by 14-3-3 (Homo sapiens)
p-S99-BAD [cytosol] (Homo sapiens)
Signal Transduction (Homo sapiens)
Intracellular signaling by second messengers (Homo sapiens)
PIP3 activates AKT signaling (Homo sapiens)
AKT phosphorylates targets in the cytosol (Homo sapiens)
AKT phosphorylates BAD (Homo sapiens)
p-S99-BAD [cytosol] (Homo sapiens)
External Reference Information
External Reference
UniProt:Q92934 BAD
Gene Names
BAD, BBC6, BCL2L8
Chain
chain:1-168
Reference Genes
BioGPS Gene:572 BAD
COSMIC (genes):BAD BAD
CTD Gene:572 BAD
dbSNP Gene:572 BAD
ENSEMBL:ENSG00000002330 BAD
HGNC:936 BAD
KEGG Gene (Homo sapiens):572 BAD
Monarch:572 BAD
NCBI Gene:572 BAD
OMIM:603167 BAD
UCSC:Q92934 BAD
Reference Transcript
RefSeq:NM_032989.2 BAD
RefSeq:NM_004322.3 BAD
Other Identifiers
0002350358
0004050010
11727106_a_at
11750088_x_at
16739872
1861_at
1G5J
209364_at
28185
3376833
3376834
3376835
3376836
3376839
3376843
3376844
3376845
4205
572
62105
7949067
A0A024R562
A8MXU7
A_23_P150207
A_33_P3262043
AAB36516
AAB72092
AAB88124
AAH01901
AAH95431
AAP35324
AB451254
AB451378
AF021792
AF031523
AK291863
BAD
BAD-201
BAD-203
BAF84552
BAG70068
BAG70192
BC001901
BC095431
BT006678
CAB004205
CAG46733
CAG46757
CCDS8065
CH471076
CR541935
CR541959
EAW74235
EAW74236
ENSG00000002330
ENSP00000309103
ENSP00000378040
ENST00000309032
ENST00000309032.7
ENST00000394532
ENST00000394532.7
EntrezGene:572
EntrezGene:BAD
F5GYS3
F5H1R6
F5H3B1
g1683636_3p_s_at
GE61740
GO:0000003
GO:0001666
GO:0001836
GO:0001844
GO:0002376
GO:0003674
GO:0005515
GO:0005543
GO:0005575
GO:0005622
GO:0005623
GO:0005737
GO:0005739
GO:0005741
GO:0005829
GO:0005975
GO:0006007
GO:0006810
GO:0006914
GO:0006915
GO:0006919
GO:0006950
GO:0007005
GO:0007049
GO:0007155
GO:0007165
GO:0007267
GO:0007283
GO:0008150
GO:0008219
GO:0008283
GO:0008289
GO:0008625
GO:0008630
GO:0008656
GO:0009056
GO:0009725
GO:0009749
GO:0010033
GO:0010508
GO:0010918
GO:0014070
GO:0016020
GO:0019050
GO:0019221
GO:0019899
GO:0019901
GO:0019903
GO:0021987
GO:0022607
GO:0030154
GO:0030234
GO:0030346
GO:0032024
GO:0032355
GO:0032570
GO:0033133
GO:0033574
GO:0034201
GO:0034641
GO:0035774
GO:0042493
GO:0042542
GO:0042592
GO:0042593
GO:0042981
GO:0043065
GO:0043167
GO:0043200
GO:0043226
GO:0043280
GO:0043281
GO:0043422
GO:0044281
GO:0044342
GO:0044403
GO:0045471
GO:0045579
GO:0045582
GO:0045862
GO:0046031
GO:0046034
GO:0046902
GO:0046931
GO:0046982
GO:0048856
GO:0050679
GO:0051384
GO:0051592
GO:0051604
GO:0060139
GO:0060154
GO:0061024
GO:0065003
GO:0071247
GO:0071260
GO:0071316
GO:0071396
GO:0071456
GO:0071889
GO:0090200
GO:0097190
GO:0097191
GO:0097192
GO:0097193
GO:0097202
GO:1900740
GO:1901216
GO:1902220
GO:1904710
GO:2000078
GO:2001244
HGNC:936
HPA028185
HPA062105
ILMN_1720360
ILMN_1738652
IPR018868
MIM:603167
NM_004322
NM_032989
NP_004313
NP_116784
PF10514
PH_hs_0004408
TC11001903.hg
U66879
U66879_at
UPI0000035C7F
Participant Of
output
AKT phosphorylates BAD
AKT1 E17K mutant phosphorylates BAD
input
Sequestration of BAD protein by 14-3-3
hasComponent
14-3-3 proteins:p-S99-BAD complex [cytosol]
Other forms of this molecule
p-S128-BAD [cytosol]
BAD [mitochondrial outer membrane]
BAD [cytosol]
Inferred To
phospho-p-S99-BAD [cytosol] (Bos taurus)
phospho-p-S99-BAD [cytosol] (Canis familiaris)
phospho-p-S99-BAD [cytosol] (Danio rerio)
phospho-p-S99-BAD [cytosol] (Mus musculus)
phospho-p-S99-BAD [cytosol] (Rattus norvegicus)
phospho-p-S99-BAD [cytosol] (Sus scrofa)
phospho-p-S99-BAD [cytosol] (Xenopus tropicalis)
Modified Residues
Name
O-phospho-L-serine at 99
Coordinate
99
PsiMod Name
O-phospho-L-serine [MOD:00046]
PsiMod Definition
A protein modification that effectively converts an L-serine residue to O-phospho-L-serine.
Cross References
ZINC - Investigational
BAD_HUMAN
RefSeq
NP_116784.1
,
NP_004313.1
OpenTargets
ENSG00000002330
ZINC - Substances
BAD_HUMAN
GeneCards
Q92934
ZINC target
Q92934
PRO
Q92934
ZINC - Predictions - Purchasable
BAD_HUMAN
PDB
1G5J
Interactors (17)
Accession
#Entities
Entities
Confidence Score
Evidence (IntAct)
UniProt:Q07817 BCL2L1
1
BCL2L1 [mitochondrial outer membrane]
(R-HSA-114236)
0.967
29
UniProt:P63104 YWHAZ
2
YWHAZ [cytosol]
(R-HSA-206099)
YWHAZ [nucleoplasm]
(R-HSA-450469)
0.822
6
UniProt:Q07817-1 BCL2L1
0.807
6
UniProt:P10415 BCL2
1
BCL2 [mitochondrial outer membrane]
(R-HSA-50757)
0.807
5
UniProt:P31947 SFN
1
SFN [cytosol]
(R-HSA-1445105)
0.745
4
UniProt:Q92843 B2CL2
0.743
4
UniProt:Q04917 YWHAH
1
YWHAH [cytosol]
(R-HSA-1445107)
0.659
3
UniProt:P27348 YWHAQ
1
YWHAQ [cytosol]
(R-HSA-1445116)
0.589
3
UniProt:P04049 RAF1
10
p-S338,Y340,Y341-RAF1 [cytosol]
(R-HSA-5624465)
RAF1 [cytosol]
(R-HSA-167205)
p-S338-RAF1 [cytosol]
(R-HSA-5624469)
p-S259,S621-RAF1 [cytosol]
(R-HSA-109786)
p-S621-RAF1 [plasma membrane]
(R-HSA-206222)
p-Y341,T491,S494,S621 RAF1 [plasma membrane]
(R-HSA-5675420)
hyperphosphorylated RAF1 [plasma membrane]
(R-HSA-5675193)
p-S621-RAF1 [cytosol]
(R-HSA-206028)
p-S338,Y341,T491,S494,S621 RAF1 [plasma membrane]
(R-HSA-5672665)
p-S338,Y341,T491,S494,S621 RAF1 [cytosol]
(R-HSA-5672664)
0.589
2
UniProt:P62258 YWHAE
1
YWHAE [cytosol]
(R-HSA-194368)
0.553
2
UniProt:P61981 YWHAG
1
YWHAG [cytosol]
(R-HSA-380312)
0.547
2
UniProt:P31946 YWHAB
1
YWHAB [cytosol]
(R-HSA-48888)
0.547
2
UniProt:P17361 N1
0.524
2
UniProt:P03495 NS1
0.508
2
UniProt:O43521 BCL2L11
7
BCL2L11-BRAF fusion [cytosol]
(R-HSA-6802276)
BCL2L11 [mitochondrial outer membrane]
(R-HSA-2976674)
p-BCL2L11-BRAF fusion [cytosol]
(R-HSA-6802519)
p-S65-BCL2L11 [cytosol]
(R-HSA-2976671)
p-BCL2L11 [mitochondrial outer membrane]
(R-HSA-3145027)
p-BCL2L11 [cytosol]
(R-HSA-140525)
BCL2L11 [cytosol]
(R-HSA-2976673)
0.499
2
UniProt:P35609 ACTN2
3
ACTN2 [platelet alpha granule lumen]
(R-HSA-349727)
ACTN2 [extracellular region]
(R-HSA-349725)
ACTN2 [cytosol]
(R-HSA-390562)
0.488
2
UniProt:Q15323 KRT31
1
KRT31 [cytosol]
(R-HSA-6809616)
0.488
2
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