Toggle navigation
About
What is Reactome ?
News
Team
Scientific Advisory Board
Funding
Editorial Calendar
Release Calendar
Statistics
Our Logo
License Agreement
Privacy Notice
Disclaimer
Digital Preservation
Contact us
Content
Table of Contents
DOIs
Data Schema
Reactome Research Spotlight
ORCID Integration Project
COVID-19 Disease Pathways
Docs
Userguide
Pathway Browser
How do I search ?
Details Panel
Analysis Tools
Analysis Data
Analysis Gene Expression
Species Comparison
Tissue Distribution
Diseases
Cytomics
Review Status of Reactome Events
ReactomeFIViz
Developer's Zone
Graph Database
Analysis Service
Content Service
Pathways Overview
Pathway Diagrams
Icon Info
EHLD Specs & Guidelines
Icon Library Guidelines
Data Model
Curator Guide
Release Documentation
Computationally inferred events
FAQ
Linking to Us
Citing us
Tools
Pathway Browser
Analyse gene list
Analyse gene expression
Species Comparison
Tissue Distribution
Analysis Service
Content Service
ReactomeFIViz
Advanced Data Search
Site Search
Community
Contribute Pathway Knowledge
Icon Library
Outreach
Events
Publications
Partners
Contributors
Resources Guide
Download
About
What is Reactome ?
News
Team
Scientific Advisory Board
Funding
Editorial Calendar
Release Calendar
Statistics
Our Logo
License Agreement
Privacy Notice
Disclaimer
Digital Preservation
Contact us
Content
Table of Contents
DOIs
Data Schema
Reactome Research Spotlight
ORCID Integration Project
COVID-19 Disease Pathways
Docs
Userguide
Pathway Browser
How do I search ?
Details Panel
Analysis Tools
Analysis Data
Analysis Gene Expression
Species Comparison
Tissue Distribution
Diseases
Cytomics
Review Status of Reactome Events
ReactomeFIViz
Developer's Zone
Graph Database
Analysis Service
Content Service
Pathways Overview
Pathway Diagrams
Icon Info
EHLD Specs & Guidelines
Icon Library Guidelines
Data Model
Curator Guide
Release Documentation
Computationally inferred events
FAQ
Linking to Us
Citing us
Tools
Pathway Browser
Analyse gene list
Analyse gene expression
Species Comparison
Tissue Distribution
Analysis Service
Content Service
ReactomeFIViz
Advanced Data Search
Site Search
Community
Contribute Pathway Knowledge
Icon Library
Outreach
Events
Publications
Partners
Contributors
Resources Guide
Download
Search ...
Go!
GSK3A [cytosol]
Stable Identifier
R-HSA-198326
Type
Protein [EntityWithAccessionedSequence]
Species
Homo sapiens
Compartment
cytosol
Synonyms
Glycogen synthase kinase-3 alpha, KG3A_HUMAN
Icon
Locations in the PathwayBrowser for interactor UniProt:Q8IUH5 ZDH17
Expand all
Cellular responses to stimuli (Homo sapiens)
Cellular responses to stress (Homo sapiens)
Unfolded Protein Response (UPR) (Homo sapiens)
IRE1alpha activates chaperones (Homo sapiens)
XBP1(S) activates chaperone genes (Homo sapiens)
Expression of GSK3A (Homo sapiens)
GSK3A [cytosol] (Homo sapiens)
Disease (Homo sapiens)
Infectious disease (Homo sapiens)
Bacterial Infection Pathways (Homo sapiens)
Infection with Mycobacterium tuberculosis (Homo sapiens)
Response of Mtb to phagocytosis (Homo sapiens)
Suppression of apoptosis (Homo sapiens)
PtpA dephosphorylates GSK3A (Homo sapiens)
GSK3A [cytosol] (Homo sapiens)
External Reference Information
External Reference
UniProt:P49840 GSK3A
Gene Names
GSK3A
Chain
initiator methionine:, chain:2-483
Reference Genes
BioGPS Gene:2931 GSK3A
COSMIC (genes):GSK3A GSK3A
CTD Gene:2931 GSK3A
dbSNP Gene:2931 GSK3A
ENSEMBL:ENSG00000105723 GSK3A
ENSEMBL_homo_sapiens_GENE:ENSG00000105723.13 GSK3A
HGNC:4616 GSK3A
KEGG Gene (Homo sapiens):2931 GSK3A
Monarch:2931 GSK3A
NCBI Gene:2931 GSK3A
OMIM:606784 GSK3A
UCSC:P49840 GSK3A
Reference Transcript
RefSeq:NM_019884.2 GSK3A
Other Identifiers
11724373_a_at
11756129_a_at
11756130_x_at
16872743
202210_3p_x_at
202210_PM_x_at
202210_x_at
2931
3863523
3863524
3863525
3863526
3863527
3863528
3863530
3863531
3863533
3863534
3863535
3863537
3863538
3863541
3863542
3863543
3863544
3863546
632_PM_at
632_at
8037152
A_24_P185394
GE54011
GE57271
GO:0000166
GO:0003012
GO:0003013
GO:0003073
GO:0003214
GO:0003824
GO:0004672
GO:0004674
GO:0005102
GO:0005515
GO:0005524
GO:0005634
GO:0005737
GO:0005739
GO:0005829
GO:0005975
GO:0005977
GO:0006091
GO:0006351
GO:0006355
GO:0006468
GO:0006886
GO:0006914
GO:0007005
GO:0007212
GO:0007399
GO:0008092
GO:0008286
GO:0009968
GO:0010508
GO:0010628
GO:0010800
GO:0010905
GO:0010975
GO:0012501
GO:0016055
GO:0016301
GO:0016310
GO:0016477
GO:0016740
GO:0018107
GO:0019082
GO:0023052
GO:0030154
GO:0030163
GO:0030424
GO:0030877
GO:0031398
GO:0032007
GO:0032436
GO:0032869
GO:0033138
GO:0034236
GO:0036016
GO:0036211
GO:0043025
GO:0043161
GO:0043226
GO:0045719
GO:0045732
GO:0045823
GO:0045944
GO:0046325
GO:0046627
GO:0048156
GO:0048856
GO:0048870
GO:0050321
GO:0050877
GO:0051093
GO:0051128
GO:0055085
GO:0055086
GO:0060079
GO:0061024
GO:0061052
GO:0071285
GO:0071385
GO:0071407
GO:0071879
GO:0090090
GO:0097191
GO:0097192
GO:0097440
GO:0098794
GO:0106071
GO:0106310
GO:0140096
GO:0141068
GO:1901030
GO:1901135
GO:1901524
GO:1902004
GO:1903955
GO:1904227
GO:1990635
GO:2000077
GO:2000466
GO:2000467
HMNXSV003043900
ILMN_1757569
L40027_at
L40027mRNA_3p_s_at
PH_hs_0020452
TC19001569.hg
g11995473_3p_s_at
Participates
as an output of
PtpA dephosphorylates GSK3A (Homo sapiens)
Expression of GSK3A (Homo sapiens)
as a member of
GSK3 [cytosol] (Homo sapiens)
Other forms of this molecule
p-S21-GSK3A [cytosol]
p-Y279-GSK3A [cytosol]
Cross References
RefSeq
NP_063937.2
ZINC - World Drugs
GSK3A_HUMAN
Guide to Pharmacology - Targets
2029
OpenTargets
ENSG00000105723
ZINC - FDA approved
GSK3A_HUMAN
ZINC - Substances
GSK3A_HUMAN
ZINC - Biogenic
GSK3A_HUMAN
ZINC target
P49840
PRO
P49840
PDB
7SXF
,
7SXG
ZINC - Investigational
GSK3A_HUMAN
IntEnz
2.7.11.1
,
2.7.11.26
HPA
ENSG00000105723-GSK3A
GeneCards
P49840
Ensembl
ENSG00000105723
,
ENST00000453535
,
ENSP00000412663
,
ENST00000222330
,
ENSP00000222330
Pharos - Targets
P49840
ZINC - Predictions - Purchasable
GSK3A_HUMAN
HMDB Protein
HMDBP01384
Interactors (25)
Accession
#Entities
Entities
Confidence Score
Evidence (IntAct)
UniProt:Q14596 NBR1
2
NBR1 [peroxisomal membrane]
(R-HSA-9665177)
NBR1 [cytosol]
(R-HSA-9665180)
0.844
7
UniProt:P61981 YWHAG
1
YWHAG [cytosol]
(R-HSA-380312)
0.813
5
UniProt:O15169 AXIN1
11
AXIN1 L396M [cytosol]
(R-HSA-5251503)
AXIN1 Y346* [cytosol]
(R-HSA-4839753)
AXIN1 E406* [cytosol]
(R-HSA-5251500)
AXIN1 W247* [cytosol]
(R-HSA-5251512)
AXIN1 P354L [cytosol]
(R-HSA-5251511)
AXIN1 P255S [cytosol]
(R-HSA-5251505)
ub-AXIN1 [cytosol]
(R-HSA-4641133)
Ub-RibC-AXIN1 [cytosol]
(R-HSA-3640864)
RibC-AXIN1 [cytosol]
(R-HSA-3640841)
p-T481,S486,S493-AXIN1 [cytosol]
(R-HSA-206040)
AXIN1 [cytosol]
(R-HSA-195249)
0.802
6
UniProt:Q92837 FRAT1
1
FRAT1 [cytosol]
(R-HSA-1226051)
0.744
5
UniProt:Q9P0R6 GSKIP
0.738
5
UniProt:Q6P3S6 FBX42
0.659
3
UniProt:Q9Y2T1 AXIN2
4
AXIN2 [cytosol]
(R-HSA-3640821)
RibC-AXIN2 [cytosol]
(R-HSA-3640842)
Ub-RibC-AXIN2 [cytosol]
(R-HSA-3640859)
ub-AXIN2 [cytosol]
(R-HSA-4641131)
0.659
4
UniProt:O75398 DEAF1
0.646
3
UniProt:O75581 LRP6
8
p-T1479,S1490,T1493-LRP6 [plasma membrane]
(R-HSA-205884)
p-S1490-LRP6 [plasma membrane]
(R-HSA-206156)
LRP6 [early endosome membrane]
(R-HSA-5368481)
p-LRP6 [early endosome membrane]
(R-HSA-5368496)
LRP6N [extracellular region]
(R-HSA-5334021)
p-2S,S1490,2T-LRP6 [plasma membrane]
(R-HSA-1458894)
p-4S,3T,T1479,S1490,T1493-LRP6 [plasma membrane]
(R-HSA-1458895)
LRP6 [plasma membrane]
(R-HSA-206252)
0.646
3
UniProt:P08238 HSP90AB1
6
HSP90AB1 [secretory granule lumen]
(R-HSA-6801477)
HSP90AB1 [extracellular region]
(R-HSA-6806463)
HSP90AB1 [ficolin-1-rich granule lumen]
(R-HSA-6801491)
HSP90AB1 [cytosol]
(R-HSA-419617)
HSP90AB1 [nucleoplasm]
(R-HSA-5082399)
HSP90AB1 [lysosomal lumen]
(R-HSA-9622846)
0.646
3
UniProt:P05067-PRO_0000000093 APP
0.618
3
UniProt:P10636-8 MAPT
3
p-S199,S202,S262,S396,S404,S409,T181,T231-MAPT-8 [cytosol]
(R-HSA-9836400)
p-S262,S356,S396-MAPT-8 [cytosol]
(R-HSA-9619521)
MAPT-8 [cytosol]
(R-HSA-9619519)
0.59
2
IntAct:EBI-25865403 EHD27213144
0.556
3
UniProt:P42858 HTT
1
HTT [nucleoplasm]
(R-HSA-9023590)
0.556
6
UniProt:Q9UKA4 AKA11
0.547
2
UniProt:Q9Y3Z3 SAMHD1
1
SAMHD1 [nucleoplasm]
(R-HSA-5624198)
0.527
2
UniProt:Q8N5C6 SRBD1
0.527
3
UniProt:P48454 PPP3CC
1
PPP3CC [cytosol]
(R-HSA-61113)
0.527
3
UniProt:O60296 TRAK2
1
TRAK2 [cytosol]
(R-HSA-9693815)
0.527
2
UniProt:P41236 IPP2
0.527
3
UniProt:Q96EG1 ARSG
2
OxA-ARSG [endoplasmic reticulum lumen]
(R-HSA-1614304)
ARSG [endoplasmic reticulum lumen]
(R-HSA-1614361)
0.527
2
UniProt:Q86TP1 PRUN1
0.527
2
UniProt:P49841 GSK3B
4
GSK3B del304-316 [cytosol]
(R-HSA-5339682)
GSK3B [nucleoplasm]
(R-HSA-2022823)
p-S9-GSK3B [cytosol]
(R-HSA-3149577)
GSK3B [cytosol]
(R-HSA-2997551)
0.527
2
UniProt:Q8IUH5 ZDH17
0.508
3
UniProt:P62258 YWHAE
1
YWHAE [cytosol]
(R-HSA-194368)
0.499
3
© 2024
Reactome
Cite Us!
Cite Us!
Cite Us!
Warning!
Unable to extract citation. Please try again later.
Download As:
BibTeX
RIS
Text