Reactome | DAG stimulates protein kinase C-delta

DAG stimulates protein kinase C-delta

Stable Identifier

R-HSA-198314

Type

Reaction [transition]

Species

Homo sapiens

Compartment

plasma membrane, cytosol

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Diacylglycerol (DAG) positively regulates the autophosphorylation of protein kinase C-delta (PKC-delta), which stimulates ERK1/2 and triggers neurite outgrowth. DAG also stimulates the translocation of PKC from the cytosol to the plasma membrane. PKC-delta contributes to growth factor specificity and response to neuronal cells by promoting cell-type-specific differences in growth factor signalling. DAG can also activate PKC-epsilon in the same manner (Newton 2001).

Literature References

PubMed ID	Title	Journal	Year
11749377	Protein kinase C: structural and spatial regulation by phosphorylation, cofactors, and macromolecular interactions Newton, AC	Chem. Rev.	2001
16678913	PKD at the crossroads of DAG and PKC signaling Wang, QJ	Trends Pharmacol. Sci.	2006