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DAG stimulates protein kinase C-delta
Stable Identifier
R-HSA-198314
Type
Reaction [transition]
Species
Homo sapiens
Compartment
plasma membrane
,
cytosol
ReviewStatus
5/5
Locations in the PathwayBrowser
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Immune System (Homo sapiens)
Innate Immune System (Homo sapiens)
Fcgamma receptor (FCGR) dependent phagocytosis (Homo sapiens)
Role of phospholipids in phagocytosis (Homo sapiens)
DAG stimulates protein kinase C-delta (Homo sapiens)
Signal Transduction (Homo sapiens)
Intracellular signaling by second messengers (Homo sapiens)
DAG and IP3 signaling (Homo sapiens)
DAG stimulates protein kinase C-delta (Homo sapiens)
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Diacylglycerol (DAG) positively regulates the autophosphorylation of protein kinase C-delta (PKC-delta), which stimulates ERK1/2 and triggers neurite outgrowth. DAG also stimulates the translocation of PKC from the cytosol to the plasma membrane. PKC-delta contributes to growth factor specificity and response to neuronal cells by promoting cell-type-specific differences in growth factor signalling. DAG can also activate PKC-epsilon in the same manner (Newton 2001).
Literature References
PubMed ID
Title
Journal
Year
16678913
PKD at the crossroads of DAG and PKC signaling
Wang, QJ
Trends Pharmacol. Sci.
2006
11749377
Protein kinase C: structural and spatial regulation by phosphorylation, cofactors, and macromolecular interactions
Newton, AC
Chem. Rev.
2001
Participants
Input
x 3
ATP [cytosol]
PKC-delta/epsilon [cytosol]
(Homo sapiens)
Output
x 3
ADP [cytosol]
Phospho-PKC-delta/epsilon [plasma membrane]
(Homo sapiens)
Participates
as an event of
DAG and IP3 signaling (Homo sapiens)
Role of phospholipids in phagocytosis (Homo sapiens)
Catalyst Activity
protein kinase C activity of PKC-delta/epsilon [cytosol]
Physical Entity
PKC-delta/epsilon [cytosol]
(Homo sapiens)
Activity
protein kinase C activity (GO:0004697)
This event is regulated
Positively by
Regulator
DAGs [plasma membrane]
Orthologous Events
DAG stimulates protein kinase C-delta (Bos taurus)
DAG stimulates protein kinase C-delta (Caenorhabditis elegans)
DAG stimulates protein kinase C-delta (Canis familiaris)
DAG stimulates protein kinase C-delta (Danio rerio)
DAG stimulates protein kinase C-delta (Dictyostelium discoideum)
DAG stimulates protein kinase C-delta (Drosophila melanogaster)
DAG stimulates protein kinase C-delta (Gallus gallus)
DAG stimulates protein kinase C-delta (Mus musculus)
DAG stimulates protein kinase C-delta (Rattus norvegicus)
DAG stimulates protein kinase C-delta (Saccharomyces cerevisiae)
DAG stimulates protein kinase C-delta (Schizosaccharomyces pombe)
DAG stimulates protein kinase C-delta (Sus scrofa)
DAG stimulates protein kinase C-delta (Xenopus tropicalis)
Reviewed
Greene, LA (2007-11-08)
Created
© 2024
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