DAG stimulates protein kinase C-delta

Stable Identifier
R-HSA-198314
Type
Reaction [transition]
Species
Homo sapiens
Compartment
plasma membrane, cytosol
ReviewStatus
5/5
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DAG stimulates protein kinase C-delta
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Diacylglycerol (DAG) positively regulates the autophosphorylation of protein kinase C-delta (PKC-delta), which stimulates ERK1/2 and triggers neurite outgrowth. DAG also stimulates the translocation of PKC from the cytosol to the plasma membrane. PKC-delta contributes to growth factor specificity and response to neuronal cells by promoting cell-type-specific differences in growth factor signalling. DAG can also activate PKC-epsilon in the same manner (Newton 2001).
Literature References
PubMed ID Title Journal Year
16678913 PKD at the crossroads of DAG and PKC signaling

Wang, QJ

Trends Pharmacol. Sci. 2006
11749377 Protein kinase C: structural and spatial regulation by phosphorylation, cofactors, and macromolecular interactions

Newton, AC

Chem. Rev. 2001
Participants
Input
Output
Participates
as an event of
Catalyst Activity

diacylglycerol-dependent, calcium-independent serine/threonine kinase activity of PKC-delta/epsilon [cytosol]

Physical Entity
PKC-delta/epsilon [cytosol] (Homo sapiens)
Activity
diacylglycerol-dependent, calcium-independent serine/threonine kinase activity (GO:0004699)
This event is regulated
Positively by
Regulator
DAG [plasma membrane]
Orthologous Events
DAG stimulates protein kinase C-delta (Bos taurus)
DAG stimulates protein kinase C-delta (Caenorhabditis elegans)
DAG stimulates protein kinase C-delta (Canis familiaris)
DAG stimulates protein kinase C-delta (Danio rerio)
DAG stimulates protein kinase C-delta (Dictyostelium discoideum)
DAG stimulates protein kinase C-delta (Drosophila melanogaster)
DAG stimulates protein kinase C-delta (Gallus gallus)
DAG stimulates protein kinase C-delta (Mus musculus)
DAG stimulates protein kinase C-delta (Rattus norvegicus)
DAG stimulates protein kinase C-delta (Saccharomyces cerevisiae)
DAG stimulates protein kinase C-delta (Schizosaccharomyces pombe)
DAG stimulates protein kinase C-delta (Sus scrofa)
DAG stimulates protein kinase C-delta (Xenopus tropicalis)
Reviewed
Greene, LA  (2007-11-08)
Created
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