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SEMA3A [extracellular region]
Stable Identifier
R-HSA-198235
Type
Protein [EntityWithAccessionedSequence]
Species
Homo sapiens
Compartment
extracellular region
Synonyms
Semaphorin 3A, SM3A_HUMAN
Icon
Locations in the PathwayBrowser
Expand all
Developmental Biology (Homo sapiens)
Nervous system development (Homo sapiens)
Axon guidance (Homo sapiens)
Semaphorin interactions (Homo sapiens)
CRMPs in Sema3A signaling (Homo sapiens)
Activation of Fyn (Homo sapiens)
Sema3A dimer [extracellular region] (Homo sapiens)
SEMA3A [extracellular region] (Homo sapiens)
Sema3A:Nrp-1:PlexinA:Fyn [plasma membrane] (Homo sapiens)
Sema3A dimer [extracellular region] (Homo sapiens)
SEMA3A [extracellular region] (Homo sapiens)
Phosphorylation of CRMPs by Cdk5 (Homo sapiens)
Sema3A:Nrp-1:PlexinA:Fyn:Cdk5:pCRMP's [plasma membrane] (Homo sapiens)
Sema3A dimer [extracellular region] (Homo sapiens)
SEMA3A [extracellular region] (Homo sapiens)
Sema3A:Nrp-1:PlexinA:Fyn:pCdk5 [plasma membrane] (Homo sapiens)
Sema3A dimer [extracellular region] (Homo sapiens)
SEMA3A [extracellular region] (Homo sapiens)
Phosphorylation of CRMPs by GSK3beta (Homo sapiens)
Sema3A:Nrp-1:PlexinA:Fyn:Cdk5:pCRMP's [plasma membrane] (Homo sapiens)
Sema3A dimer [extracellular region] (Homo sapiens)
SEMA3A [extracellular region] (Homo sapiens)
Recruitment and activation of Cdk5 (Homo sapiens)
Sema3A:Nrp-1:PlexinA:Fyn [plasma membrane] (Homo sapiens)
Sema3A dimer [extracellular region] (Homo sapiens)
SEMA3A [extracellular region] (Homo sapiens)
Sema3A:Nrp-1:PlexinA:Fyn:pCdk5 [plasma membrane] (Homo sapiens)
Sema3A dimer [extracellular region] (Homo sapiens)
SEMA3A [extracellular region] (Homo sapiens)
Tyrosine phosphorylation of CRMPs by Fes (Homo sapiens)
Sema3A:NP-1:Plexin-A:Fes:CRMP [plasma membrane] (Homo sapiens)
Sema3A:NRP-1:pPlexin-A:Fyn:Fes [plasma membrane] (Homo sapiens)
Sema3A:NRP-1:pPlexin-A:fyn [plasma membrane] (Homo sapiens)
Sema3A dimer [extracellular region] (Homo sapiens)
SEMA3A [extracellular region] (Homo sapiens)
Sema3A:NRP-1:pPlexin-A:Fyn:Fes [plasma membrane] (Homo sapiens)
Sema3A:NRP-1:pPlexin-A:fyn [plasma membrane] (Homo sapiens)
Sema3A dimer [extracellular region] (Homo sapiens)
SEMA3A [extracellular region] (Homo sapiens)
SEMA3A-Plexin repulsion signaling by inhibiting Integrin adhesion (Homo sapiens)
Inactivation of R-Ras by Sema3A-Plexin-A GAP activity (Homo sapiens)
Sema3A:Nrp-1:pPlexinA:Fyn:Fes:Rac-1-GTP:Rnd1 [plasma membrane] (Homo sapiens)
Sema3A:Nrp-1:pPlexinA:Fyn:Fes:Rac-1-GTP [plasma membrane] (Homo sapiens)
Sema3A:NRP-1:pPlexin-A:Fyn:Fes [plasma membrane] (Homo sapiens)
Sema3A:NRP-1:pPlexin-A:fyn [plasma membrane] (Homo sapiens)
Sema3A dimer [extracellular region] (Homo sapiens)
SEMA3A [extracellular region] (Homo sapiens)
Phosphorylation of Plexin-A (Homo sapiens)
Sema3A:NRP-1:pPlexin-A:Fyn:Fes [plasma membrane] (Homo sapiens)
Sema3A:NRP-1:pPlexin-A:fyn [plasma membrane] (Homo sapiens)
Sema3A dimer [extracellular region] (Homo sapiens)
SEMA3A [extracellular region] (Homo sapiens)
Sema3A:Nrp-1:Plexin A:Fyn [plasma membrane] (Homo sapiens)
Sema3A dimer [extracellular region] (Homo sapiens)
SEMA3A [extracellular region] (Homo sapiens)
Rac1 binds PlexinA (Homo sapiens)
Sema3A:NRP-1:pPlexin-A:Fyn:Fes [plasma membrane] (Homo sapiens)
Sema3A:NRP-1:pPlexin-A:fyn [plasma membrane] (Homo sapiens)
Sema3A dimer [extracellular region] (Homo sapiens)
SEMA3A [extracellular region] (Homo sapiens)
Sema3A:Nrp-1:pPlexinA:Fyn:Fes:Rac-1-GTP [plasma membrane] (Homo sapiens)
Sema3A:NRP-1:pPlexin-A:Fyn:Fes [plasma membrane] (Homo sapiens)
Sema3A:NRP-1:pPlexin-A:fyn [plasma membrane] (Homo sapiens)
Sema3A dimer [extracellular region] (Homo sapiens)
SEMA3A [extracellular region] (Homo sapiens)
Recruitment of Rnd1 to Plexin A (Homo sapiens)
Sema3A:Nrp-1:pPlexinA:Fyn:Fes:Rac-1-GTP [plasma membrane] (Homo sapiens)
Sema3A:NRP-1:pPlexin-A:Fyn:Fes [plasma membrane] (Homo sapiens)
Sema3A:NRP-1:pPlexin-A:fyn [plasma membrane] (Homo sapiens)
Sema3A dimer [extracellular region] (Homo sapiens)
SEMA3A [extracellular region] (Homo sapiens)
Sema3A:Nrp-1:pPlexinA:Fyn:Fes:Rac-1-GTP:Rnd1 [plasma membrane] (Homo sapiens)
Sema3A:Nrp-1:pPlexinA:Fyn:Fes:Rac-1-GTP [plasma membrane] (Homo sapiens)
Sema3A:NRP-1:pPlexin-A:Fyn:Fes [plasma membrane] (Homo sapiens)
Sema3A:NRP-1:pPlexin-A:fyn [plasma membrane] (Homo sapiens)
Sema3A dimer [extracellular region] (Homo sapiens)
SEMA3A [extracellular region] (Homo sapiens)
Sema3A binds Nrp-1 bound to PlexinA (Homo sapiens)
Sema3A dimer [extracellular region] (Homo sapiens)
SEMA3A [extracellular region] (Homo sapiens)
Sema3A:Nrp-1:Plexin A:Fyn [plasma membrane] (Homo sapiens)
Sema3A dimer [extracellular region] (Homo sapiens)
SEMA3A [extracellular region] (Homo sapiens)
Sema3A PAK dependent Axon repulsion (Homo sapiens)
Activation of PAK by Rac1 (Homo sapiens)
Sema3A:Nrp-1:PlexinA:Rac1-GTP:PAK [plasma membrane] (Homo sapiens)
Sema3A:Nrp-1:pPlexinA:Fyn:Fes:Rac-1-GTP [plasma membrane] (Homo sapiens)
Sema3A:NRP-1:pPlexin-A:Fyn:Fes [plasma membrane] (Homo sapiens)
Sema3A:NRP-1:pPlexin-A:fyn [plasma membrane] (Homo sapiens)
Sema3A dimer [extracellular region] (Homo sapiens)
SEMA3A [extracellular region] (Homo sapiens)
Sema3A:Nrp-1:pPlexinA:Fyn:Fes:Rac-1-GTP [plasma membrane] (Homo sapiens)
Sema3A:NRP-1:pPlexin-A:Fyn:Fes [plasma membrane] (Homo sapiens)
Sema3A:NRP-1:pPlexin-A:fyn [plasma membrane] (Homo sapiens)
Sema3A dimer [extracellular region] (Homo sapiens)
SEMA3A [extracellular region] (Homo sapiens)
Autophosphorylation of PAK (Homo sapiens)
Sema3A:Nrp-1:PlexinA:Rac1-GTP:PAK [plasma membrane] (Homo sapiens)
Sema3A:Nrp-1:pPlexinA:Fyn:Fes:Rac-1-GTP [plasma membrane] (Homo sapiens)
Sema3A:NRP-1:pPlexin-A:Fyn:Fes [plasma membrane] (Homo sapiens)
Sema3A:NRP-1:pPlexin-A:fyn [plasma membrane] (Homo sapiens)
Sema3A dimer [extracellular region] (Homo sapiens)
SEMA3A [extracellular region] (Homo sapiens)
Sema3A:Nrp-1:PlexinA:Rac1-GTP:pPAK [plasma membrane] (Homo sapiens)
Sema3A:Nrp-1:pPlexinA:Fyn:Fes:Rac-1-GTP [plasma membrane] (Homo sapiens)
Sema3A:NRP-1:pPlexin-A:Fyn:Fes [plasma membrane] (Homo sapiens)
Sema3A:NRP-1:pPlexin-A:fyn [plasma membrane] (Homo sapiens)
Sema3A dimer [extracellular region] (Homo sapiens)
SEMA3A [extracellular region] (Homo sapiens)
Phosphorylation of LIMK-1 by PAK (Homo sapiens)
Sema3A:Nrp-1:PlexinA:Rac1-GTP:pPAK [plasma membrane] (Homo sapiens)
Sema3A:Nrp-1:pPlexinA:Fyn:Fes:Rac-1-GTP [plasma membrane] (Homo sapiens)
Sema3A:NRP-1:pPlexin-A:Fyn:Fes [plasma membrane] (Homo sapiens)
Sema3A:NRP-1:pPlexin-A:fyn [plasma membrane] (Homo sapiens)
Sema3A dimer [extracellular region] (Homo sapiens)
SEMA3A [extracellular region] (Homo sapiens)
External Reference Information
External Reference
UniProt:Q14563 SEMA3A
Gene Names
SEMA3A, SEMAD
Chain
signal peptide:1-20, chain:21-771
Reference Genes
BioGPS Gene:10371 SEMA3A
COSMIC (genes):SEMA3A SEMA3A
CTD Gene:10371 SEMA3A
dbSNP Gene:10371 SEMA3A
ENSEMBL:ENSG00000075213 SEMA3A
HGNC:10723 SEMA3A
KEGG:hsa:10371 SEMA3A
Monarch:10371 SEMA3A
NCBI Gene:10371 SEMA3A
OMIM:603961 SEMA3A
UCSC:Q14563 SEMA3A
Reference Transcript
RefSeq:XM_006715839.3 SEMA3A
RefSeq:XM_005250110.3 SEMA3A
RefSeq:XM_011515734.2 SEMA3A
RefSeq:NM_006080.2 SEMA3A
RefSeq:XM_005250111.4 SEMA3A
RefSeq:XM_017011673.1 SEMA3A
Other Identifiers
10371
11730390_at
11730391_at
17059323
206805_PM_at
206805_at
244163_PM_at
244163_at
3059473
3059474
3059475
3059476
3059477
3059478
3059479
3059485
3059488
3059490
3059491
3059492
3059493
3059494
3059495
3059497
3059498
3059500
3059506
3059507
3059512
3059515
3059516
3059522
3059523
3059524
3059540
3059541
3059542
3059543
3059570
33461_at
49074_at
70137_at
74956_at
8140668
A_23_P317591
A_24_P192301
GE494191
GE57698
GO:0001755
GO:0001764
GO:0005515
GO:0005576
GO:0005615
GO:0005886
GO:0007399
GO:0007411
GO:0008045
GO:0010977
GO:0021612
GO:0021637
GO:0021675
GO:0021772
GO:0021785
GO:0030154
GO:0030215
GO:0030335
GO:0030424
GO:0030425
GO:0030517
GO:0038191
GO:0045499
GO:0046330
GO:0048018
GO:0048485
GO:0048841
GO:0048846
GO:0048856
GO:0048870
GO:0048880
GO:0050919
GO:0060385
GO:0061549
GO:0071526
GO:0097490
GO:0097491
GO:0098772
GO:0098978
GO:0150020
GO:1901166
HMNXSV003014887
Hs.98279.0.A1_3p_at
Hs.98279.1.S1_3p_at
ILMN_1765641
L26081_at
PH_hs_0023240
TC07001568.hg
g5174672_3p_at
Participates
as a component of
Sema3A dimer [extracellular region] (Homo sapiens)
Inferred To
sema3a [extracellular region]
(Xenopus tropicalis)
smp-1 [extracellular region]
(Caenorhabditis elegans)
Homologues of SEMA3A [extracellular region]
(Caenorhabditis elegans)
Homologues of SEMA3A [extracellular region]
(Drosophila melanogaster)
Sema2b [extracellular region]
(Drosophila melanogaster)
Sema1a [extracellular region]
(Drosophila melanogaster)
Sema1b [extracellular region]
(Drosophila melanogaster)
Sema2a [extracellular region]
(Drosophila melanogaster)
sema3ab [extracellular region]
(Danio rerio)
smp-2 [extracellular region]
(Caenorhabditis elegans)
SEMA3A [extracellular region]
(Bos taurus)
SEMA3A [extracellular region]
(Canis familiaris)
SEMA3A [extracellular region]
(Gallus gallus)
SEMA3A [extracellular region]
(Sus scrofa)
Sema3a [extracellular region]
(Mus musculus)
Sema3a [extracellular region]
(Rattus norvegicus)
mab-20 [extracellular region]
(Caenorhabditis elegans)
Cross References
RefSeq
XP_005250168.1
,
XP_016867162.1
,
XP_005250167.1
,
XP_006715902.1
,
NP_006071.1
,
XP_011514036.1
ENSEMBL
ENST00000265362
,
ENSP00000265362
,
ENST00000436949
,
ENSP00000415260
OpenTargets
ENSG00000075213
HPA
ENSG00000075213-SEMA3A
PRO
Q14563
Pharos - Targets
Q14563
GlyGen
Q14563
Orphanet
SEMA3A
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