Reactome | TCRA [plasma membrane]

TCRA [plasma membrane]

Stable Identifier

R-HSA-198180

Type

Protein [EntityWithAccessionedSequence]

Species

Homo sapiens

Compartment

plasma membrane

Synonyms

T-cell receptor alpha chain V region CTL-L17 precursor, TVA2_HUMAN

Locations in the PathwayBrowser

Expand all

Immune System (Homo sapiens)

- Adaptive Immune System (Homo sapiens)
  - Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell (Homo sapiens)
    - TCR binds microbial lipid-based antigen via CD1 (Homo sapiens)
      - CD1:B2M:microbial lipid:TCR [plasma membrane] (Homo sapiens)
        
        T-cell receptor complex [plasma membrane] (Homo sapiens)
        
        T-cell receptor [plasma membrane] (Homo sapiens)
        
        TCR chain alpha [plasma membrane] (Homo sapiens)
        
        TCRA [plasma membrane] (Homo sapiens)
      - T-cell receptor complex [plasma membrane] (Homo sapiens)
        
        T-cell receptor [plasma membrane] (Homo sapiens)
        
        TCR chain alpha [plasma membrane] (Homo sapiens)
        
        TCRA [plasma membrane] (Homo sapiens)
    - TCR binds self-lipid-based antigen via CD1 (Homo sapiens)
      - CD1:B2M:self-lipid:TCR [plasma membrane] (Homo sapiens)
        
        T-cell receptor complex [plasma membrane] (Homo sapiens)
        
        T-cell receptor [plasma membrane] (Homo sapiens)
        
        TCR chain alpha [plasma membrane] (Homo sapiens)
        
        TCRA [plasma membrane] (Homo sapiens)
      - T-cell receptor complex [plasma membrane] (Homo sapiens)
        
        T-cell receptor [plasma membrane] (Homo sapiens)
        
        TCR chain alpha [plasma membrane] (Homo sapiens)
        
        TCRA [plasma membrane] (Homo sapiens)
    - TCR complex interacts with peptide antigen-presenting MHC Class I (Homo sapiens)
      - T-cell receptor complex with CD8 [plasma membrane] (Homo sapiens)
        
        T-cell receptor complex [plasma membrane] (Homo sapiens)
        
        T-cell receptor [plasma membrane] (Homo sapiens)
        
        TCR chain alpha [plasma membrane] (Homo sapiens)
        
        TCRA [plasma membrane] (Homo sapiens)
      - TCR interacting with antigen-bearing MHC Class I [plasma membrane] (Homo sapiens)
        
        T-cell receptor complex with CD8 [plasma membrane] (Homo sapiens)
        
        T-cell receptor complex [plasma membrane] (Homo sapiens)
        
        T-cell receptor [plasma membrane] (Homo sapiens)
        
        TCR chain alpha [plasma membrane] (Homo sapiens)
        
        TCRA [plasma membrane] (Homo sapiens)
  - Regulation of T cell activation by CD28 family (Homo sapiens)
    - Co-inhibition by PD-1 (Homo sapiens)
      - Dephosphorylation of CD3-zeta by PD-1 bound phosphatases (Homo sapiens)
        
        Antigen-bearing MHC Class II: TCR with dephosphorylated CD3 zeta chain:CD4 [plasma membrane] (Homo sapiens)
        
        T-cell receptor complex with dephosphorylated CD3 zeta chain [plasma membrane] (Homo sapiens)
        
        T-cell receptor [plasma membrane] (Homo sapiens)
        
        TCR chain alpha [plasma membrane] (Homo sapiens)
        
        TCRA [plasma membrane] (Homo sapiens)
        
        Antigen-bearing MHC Class II: TCR with phosphorylated ITAMs:CD4 [plasma membrane] (Homo sapiens)
        
        T-cell receptor complex with phosphorylated ITAMs [plasma membrane] (Homo sapiens)
        
        T-cell receptor [plasma membrane] (Homo sapiens)
        
        TCR chain alpha [plasma membrane] (Homo sapiens)
        
        TCRA [plasma membrane] (Homo sapiens)
  - TCR signaling (Homo sapiens)
    - Downstream TCR signaling (Homo sapiens)
      - Change of PKC theta conformation (Homo sapiens)
        
        Antigen-bearing MHC Class II :TCR complex:CD4: Lck phosphorylated at Tyr394 [plasma membrane] (Homo sapiens)
        
        T-cell receptor complex [plasma membrane] (Homo sapiens)
        
        T-cell receptor [plasma membrane] (Homo sapiens)
        
        TCR chain alpha [plasma membrane] (Homo sapiens)
        
        TCRA [plasma membrane] (Homo sapiens)
    - Generation of second messenger molecules (Homo sapiens)
      - Phosphorylation of PLC-gamma1 (Homo sapiens)
        
        ZAP-70 and ITK tyrosine kinases [plasma membrane] (Homo sapiens)
        
        Activated ZAP-70 [plasma membrane] (Homo sapiens)
        
        Antigen-bearing MHC Class II: TCR with phosphorylated ITAMs:CD4 [plasma membrane] (Homo sapiens)
        
        T-cell receptor complex with phosphorylated ITAMs [plasma membrane] (Homo sapiens)
        
        T-cell receptor [plasma membrane] (Homo sapiens)
        
        TCR chain alpha [plasma membrane] (Homo sapiens)
        
        TCRA [plasma membrane] (Homo sapiens)
      - Phosphorylation of SLP-76 (Homo sapiens)
        
        Activated ZAP-70 [plasma membrane] (Homo sapiens)
        
        Antigen-bearing MHC Class II: TCR with phosphorylated ITAMs:CD4 [plasma membrane] (Homo sapiens)
        
        T-cell receptor complex with phosphorylated ITAMs [plasma membrane] (Homo sapiens)
        
        T-cell receptor [plasma membrane] (Homo sapiens)
        
        TCR chain alpha [plasma membrane] (Homo sapiens)
        
        TCRA [plasma membrane] (Homo sapiens)
      - Phosphorylation of TBSMs in LAT (Homo sapiens)
        
        Activated ZAP-70 [plasma membrane] (Homo sapiens)
        
        Antigen-bearing MHC Class II: TCR with phosphorylated ITAMs:CD4 [plasma membrane] (Homo sapiens)
        
        T-cell receptor complex with phosphorylated ITAMs [plasma membrane] (Homo sapiens)
        
        T-cell receptor [plasma membrane] (Homo sapiens)
        
        TCR chain alpha [plasma membrane] (Homo sapiens)
        
        TCRA [plasma membrane] (Homo sapiens)
    - Phosphorylation of CD3 and TCR zeta chains (Homo sapiens)
      - Activation of Lck (Homo sapiens)
        
        Antigen-bearing MHC Class II : TCR complex:CD4:Lck [plasma membrane] (Homo sapiens)
        
        T-cell receptor complex [plasma membrane] (Homo sapiens)
        
        T-cell receptor [plasma membrane] (Homo sapiens)
        
        TCR chain alpha [plasma membrane] (Homo sapiens)
        
        TCRA [plasma membrane] (Homo sapiens)
        
        Antigen-bearing MHC Class II :TCR complex:CD4: Lck phosphorylated at Tyr394 [plasma membrane] (Homo sapiens)
        
        T-cell receptor complex [plasma membrane] (Homo sapiens)
        
        T-cell receptor [plasma membrane] (Homo sapiens)
        
        TCR chain alpha [plasma membrane] (Homo sapiens)
        
        TCRA [plasma membrane] (Homo sapiens)
      - Dephosphorylation of Lck-pY505 by CD45 (Homo sapiens)
        
        Antigen-bearing MHC Class II : TCR complex:CD4:Lck [plasma membrane] (Homo sapiens)
        
        T-cell receptor complex [plasma membrane] (Homo sapiens)
        
        T-cell receptor [plasma membrane] (Homo sapiens)
        
        TCR chain alpha [plasma membrane] (Homo sapiens)
        
        TCRA [plasma membrane] (Homo sapiens)
        
        Antigen-bearing MHC Class II : TCR complex:CD4:p-Lck(Y505) [plasma membrane] (Homo sapiens)
        
        T-cell receptor complex [plasma membrane] (Homo sapiens)
        
        T-cell receptor [plasma membrane] (Homo sapiens)
        
        TCR chain alpha [plasma membrane] (Homo sapiens)
        
        TCRA [plasma membrane] (Homo sapiens)
      - Inactivation of LCK by PTPN22 (Homo sapiens)
        
        Antigen-bearing MHC Class II : TCR complex:CD4:Lck [plasma membrane] (Homo sapiens)
        
        T-cell receptor complex [plasma membrane] (Homo sapiens)
        
        T-cell receptor [plasma membrane] (Homo sapiens)
        
        TCR chain alpha [plasma membrane] (Homo sapiens)
        
        TCRA [plasma membrane] (Homo sapiens)
        
        Antigen-bearing MHC Class II :TCR complex:CD4: Lck phosphorylated at Tyr394 [plasma membrane] (Homo sapiens)
        
        T-cell receptor complex [plasma membrane] (Homo sapiens)
        
        T-cell receptor [plasma membrane] (Homo sapiens)
        
        TCR chain alpha [plasma membrane] (Homo sapiens)
        
        TCRA [plasma membrane] (Homo sapiens)
      - Inactivation of Lck by Csk (Homo sapiens)
        
        Antigen-bearing MHC Class II : TCR complex:CD4:Lck [plasma membrane] (Homo sapiens)
        
        T-cell receptor complex [plasma membrane] (Homo sapiens)
        
        T-cell receptor [plasma membrane] (Homo sapiens)
        
        TCR chain alpha [plasma membrane] (Homo sapiens)
        
        TCRA [plasma membrane] (Homo sapiens)
        
        Antigen-bearing MHC Class II : TCR complex:CD4:p-Lck(Y505) [plasma membrane] (Homo sapiens)
        
        T-cell receptor complex [plasma membrane] (Homo sapiens)
        
        T-cell receptor [plasma membrane] (Homo sapiens)
        
        TCR chain alpha [plasma membrane] (Homo sapiens)
        
        TCRA [plasma membrane] (Homo sapiens)
      - Phosphorylation of ITAM motifs in CD3 complexes (Homo sapiens)
        
        Antigen-bearing MHC Class II :TCR complex:CD4: Lck phosphorylated at Tyr394 [plasma membrane] (Homo sapiens)
        
        T-cell receptor complex [plasma membrane] (Homo sapiens)
        
        T-cell receptor [plasma membrane] (Homo sapiens)
        
        TCR chain alpha [plasma membrane] (Homo sapiens)
        
        TCRA [plasma membrane] (Homo sapiens)
        
        Antigen-bearing MHC Class II: TCR with phosphorylated ITAMs:CD4 [plasma membrane] (Homo sapiens)
        
        T-cell receptor complex with phosphorylated ITAMs [plasma membrane] (Homo sapiens)
        
        T-cell receptor [plasma membrane] (Homo sapiens)
        
        TCR chain alpha [plasma membrane] (Homo sapiens)
        
        TCRA [plasma membrane] (Homo sapiens)
    - Translocation of ZAP-70 to Immunological synapse (Homo sapiens)
      - Activation of ZAP-70 (Homo sapiens)
        
        Activated ZAP-70 [plasma membrane] (Homo sapiens)
        
        Antigen-bearing MHC Class II: TCR with phosphorylated ITAMs:CD4 [plasma membrane] (Homo sapiens)
        
        T-cell receptor complex with phosphorylated ITAMs [plasma membrane] (Homo sapiens)
        
        T-cell receptor [plasma membrane] (Homo sapiens)
        
        TCR chain alpha [plasma membrane] (Homo sapiens)
        
        TCRA [plasma membrane] (Homo sapiens)
        
        phospho tyrosine ZAP-70 [plasma membrane] (Homo sapiens)
        
        Antigen-bearing MHC Class II: TCR with phosphorylated ITAMs:CD4 [plasma membrane] (Homo sapiens)
        
        T-cell receptor complex with phosphorylated ITAMs [plasma membrane] (Homo sapiens)
        
        T-cell receptor [plasma membrane] (Homo sapiens)
        
        TCR chain alpha [plasma membrane] (Homo sapiens)
        
        TCRA [plasma membrane] (Homo sapiens)
      - PTPN22 dephosphorylates ZAP70 (Homo sapiens)
        
        ZAP-70 bound to phosphorylated ITAM motifs [plasma membrane] (Homo sapiens)
        
        Antigen-bearing MHC Class II: TCR with phosphorylated ITAMs:CD4 [plasma membrane] (Homo sapiens)
        
        T-cell receptor complex with phosphorylated ITAMs [plasma membrane] (Homo sapiens)
        
        T-cell receptor [plasma membrane] (Homo sapiens)
        
        TCR chain alpha [plasma membrane] (Homo sapiens)
        
        TCRA [plasma membrane] (Homo sapiens)
        
        phospho tyrosine ZAP-70 [plasma membrane] (Homo sapiens)
        
        Antigen-bearing MHC Class II: TCR with phosphorylated ITAMs:CD4 [plasma membrane] (Homo sapiens)
        
        T-cell receptor complex with phosphorylated ITAMs [plasma membrane] (Homo sapiens)
        
        T-cell receptor [plasma membrane] (Homo sapiens)
        
        TCR chain alpha [plasma membrane] (Homo sapiens)
        
        TCRA [plasma membrane] (Homo sapiens)
      - Phosphorylation of ZAP-70 by Lck (Homo sapiens)
        
        Antigen-bearing MHC Class II :TCR complex:CD4: Lck phosphorylated at Tyr394 [plasma membrane] (Homo sapiens)
        
        T-cell receptor complex [plasma membrane] (Homo sapiens)
        
        T-cell receptor [plasma membrane] (Homo sapiens)
        
        TCR chain alpha [plasma membrane] (Homo sapiens)
        
        TCRA [plasma membrane] (Homo sapiens)
        
        ZAP-70 bound to phosphorylated ITAM motifs [plasma membrane] (Homo sapiens)
        
        Antigen-bearing MHC Class II: TCR with phosphorylated ITAMs:CD4 [plasma membrane] (Homo sapiens)
        
        T-cell receptor complex with phosphorylated ITAMs [plasma membrane] (Homo sapiens)
        
        T-cell receptor [plasma membrane] (Homo sapiens)
        
        TCR chain alpha [plasma membrane] (Homo sapiens)
        
        TCRA [plasma membrane] (Homo sapiens)
        
        phospho tyrosine ZAP-70 [plasma membrane] (Homo sapiens)
        
        Antigen-bearing MHC Class II: TCR with phosphorylated ITAMs:CD4 [plasma membrane] (Homo sapiens)
        
        T-cell receptor complex with phosphorylated ITAMs [plasma membrane] (Homo sapiens)
        
        T-cell receptor [plasma membrane] (Homo sapiens)
        
        TCR chain alpha [plasma membrane] (Homo sapiens)
        
        TCRA [plasma membrane] (Homo sapiens)
      - Recruitment of ZAP-70 to phosphorylated ITAMs (Homo sapiens)
        
        Antigen-bearing MHC Class II: TCR with phosphorylated ITAMs:CD4 [plasma membrane] (Homo sapiens)
        
        T-cell receptor complex with phosphorylated ITAMs [plasma membrane] (Homo sapiens)
        
        T-cell receptor [plasma membrane] (Homo sapiens)
        
        TCR chain alpha [plasma membrane] (Homo sapiens)
        
        TCRA [plasma membrane] (Homo sapiens)
        
        ZAP-70 bound to phosphorylated ITAM motifs [plasma membrane] (Homo sapiens)
        
        Antigen-bearing MHC Class II: TCR with phosphorylated ITAMs:CD4 [plasma membrane] (Homo sapiens)
        
        T-cell receptor complex with phosphorylated ITAMs [plasma membrane] (Homo sapiens)
        
        T-cell receptor [plasma membrane] (Homo sapiens)
        
        TCR chain alpha [plasma membrane] (Homo sapiens)
        
        TCRA [plasma membrane] (Homo sapiens)

External Reference Information

External Reference

UniProt:P04437 TRAV29DV5

Gene Names

TRAV29DV5

Chain

signal peptide:1-21, chain:22-119

Reference Genes

ENSEMBL:ENSG00000211810 TRAV29DV5

HGNC:12127 TRAV29DV5

UCSC:P04437 TRAV29DV5

Other Identifiers

16781954

3528404

3528405

3528406

3528407

3528408

3528409

A_24_P229151

GO:0002250

GO:0002376

GO:0005886

GO:0006955

GO:0016020

GO:0042101

GO:0042287

GO:0042605

HMNXSV003009391

Participates

as a member of

TCR chain alpha [plasma membrane] (Homo sapiens)

Inferred To

ENSRNOG00000065769 [plasma membrane] (Rattus norvegicus)

TCRA [plasma membrane] (Bos taurus)

TRAV29DV5 [plasma membrane] (Canis familiaris)

Trav19 [plasma membrane] (Mus musculus)

Cross References

ENSEMBL

ENST00000390458, ENSP00000452209, ENSG00000211810

OpenTargets

ENSG00000211810

GeneCards

TRAV29DV5

HPA

ENSG00000211810-TRAV29DV5

PRO

P04437

Pharos - Targets

P04437

GlyGen

P04437

PDB

1BD2

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