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TRAC [plasma membrane]
Stable Identifier
R-HSA-198175
Type
Protein [EntityWithAccessionedSequence]
Species
Homo sapiens
Compartment
plasma membrane
Synonyms
T-cell receptor alpha chain C region, TCA_HUMAN
Locations in the PathwayBrowser
Expand all
Immune System (Homo sapiens)
Adaptive Immune System (Homo sapiens)
Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell (Homo sapiens)
TCR binds microbial lipid-based antigen via CD1 (Homo sapiens)
CD1:B2M:microbial lipid:TCR [plasma membrane] (Homo sapiens)
T-cell receptor complex [plasma membrane] (Homo sapiens)
T-cell receptor [plasma membrane] (Homo sapiens)
TCR chain alpha [plasma membrane] (Homo sapiens)
TRAC [plasma membrane] (Homo sapiens)
T-cell receptor complex [plasma membrane] (Homo sapiens)
T-cell receptor [plasma membrane] (Homo sapiens)
TCR chain alpha [plasma membrane] (Homo sapiens)
TRAC [plasma membrane] (Homo sapiens)
TCR binds self-lipid-based antigen via CD1 (Homo sapiens)
CD1:B2M:self-lipid:TCR [plasma membrane] (Homo sapiens)
T-cell receptor complex [plasma membrane] (Homo sapiens)
T-cell receptor [plasma membrane] (Homo sapiens)
TCR chain alpha [plasma membrane] (Homo sapiens)
TRAC [plasma membrane] (Homo sapiens)
T-cell receptor complex [plasma membrane] (Homo sapiens)
T-cell receptor [plasma membrane] (Homo sapiens)
TCR chain alpha [plasma membrane] (Homo sapiens)
TRAC [plasma membrane] (Homo sapiens)
TCR complex interacts with peptide antigen-presenting MHC Class I (Homo sapiens)
T-cell receptor complex with CD8 [plasma membrane] (Homo sapiens)
T-cell receptor complex [plasma membrane] (Homo sapiens)
T-cell receptor [plasma membrane] (Homo sapiens)
TCR chain alpha [plasma membrane] (Homo sapiens)
TRAC [plasma membrane] (Homo sapiens)
TCR interacting with antigen-bearing MHC Class I [plasma membrane] (Homo sapiens)
T-cell receptor complex with CD8 [plasma membrane] (Homo sapiens)
T-cell receptor complex [plasma membrane] (Homo sapiens)
T-cell receptor [plasma membrane] (Homo sapiens)
TCR chain alpha [plasma membrane] (Homo sapiens)
TRAC [plasma membrane] (Homo sapiens)
Regulation of T cell activation by CD28 family (Homo sapiens)
Co-inhibition by PD-1 (Homo sapiens)
Dephosphorylation of CD3-zeta by PD-1 bound phosphatases (Homo sapiens)
Antigen-bearing MHC Class II: TCR with dephosphorylated CD3 zeta chain:CD4 [plasma membrane] (Homo sapiens)
T-cell receptor complex with dephosphorylated CD3 zeta chain [plasma membrane] (Homo sapiens)
T-cell receptor [plasma membrane] (Homo sapiens)
TCR chain alpha [plasma membrane] (Homo sapiens)
TRAC [plasma membrane] (Homo sapiens)
Antigen-bearing MHC Class II: TCR with phosphorylated ITAMs:CD4 [plasma membrane] (Homo sapiens)
T-cell receptor complex with phosphorylated ITAMs [plasma membrane] (Homo sapiens)
T-cell receptor [plasma membrane] (Homo sapiens)
TCR chain alpha [plasma membrane] (Homo sapiens)
TRAC [plasma membrane] (Homo sapiens)
TCR signaling (Homo sapiens)
Downstream TCR signaling (Homo sapiens)
Change of PKC theta conformation (Homo sapiens)
Antigen-bearing MHC Class II :TCR complex:CD4: Lck phosphorylated at Tyr394 [plasma membrane] (Homo sapiens)
T-cell receptor complex [plasma membrane] (Homo sapiens)
T-cell receptor [plasma membrane] (Homo sapiens)
TCR chain alpha [plasma membrane] (Homo sapiens)
TRAC [plasma membrane] (Homo sapiens)
Generation of second messenger molecules (Homo sapiens)
Phosphorylation of PLC-gamma1 (Homo sapiens)
ZAP-70 and ITK tyrosine kinases [plasma membrane] (Homo sapiens)
Activated ZAP-70 [plasma membrane] (Homo sapiens)
Antigen-bearing MHC Class II: TCR with phosphorylated ITAMs:CD4 [plasma membrane] (Homo sapiens)
T-cell receptor complex with phosphorylated ITAMs [plasma membrane] (Homo sapiens)
T-cell receptor [plasma membrane] (Homo sapiens)
TCR chain alpha [plasma membrane] (Homo sapiens)
TRAC [plasma membrane] (Homo sapiens)
Phosphorylation of SLP-76 (Homo sapiens)
Activated ZAP-70 [plasma membrane] (Homo sapiens)
Antigen-bearing MHC Class II: TCR with phosphorylated ITAMs:CD4 [plasma membrane] (Homo sapiens)
T-cell receptor complex with phosphorylated ITAMs [plasma membrane] (Homo sapiens)
T-cell receptor [plasma membrane] (Homo sapiens)
TCR chain alpha [plasma membrane] (Homo sapiens)
TRAC [plasma membrane] (Homo sapiens)
Phosphorylation of TBSMs in LAT (Homo sapiens)
Activated ZAP-70 [plasma membrane] (Homo sapiens)
Antigen-bearing MHC Class II: TCR with phosphorylated ITAMs:CD4 [plasma membrane] (Homo sapiens)
T-cell receptor complex with phosphorylated ITAMs [plasma membrane] (Homo sapiens)
T-cell receptor [plasma membrane] (Homo sapiens)
TCR chain alpha [plasma membrane] (Homo sapiens)
TRAC [plasma membrane] (Homo sapiens)
Phosphorylation of CD3 and TCR zeta chains (Homo sapiens)
Activation of Lck (Homo sapiens)
Antigen-bearing MHC Class II : TCR complex:CD4:Lck [plasma membrane] (Homo sapiens)
T-cell receptor complex [plasma membrane] (Homo sapiens)
T-cell receptor [plasma membrane] (Homo sapiens)
TCR chain alpha [plasma membrane] (Homo sapiens)
TRAC [plasma membrane] (Homo sapiens)
Antigen-bearing MHC Class II :TCR complex:CD4: Lck phosphorylated at Tyr394 [plasma membrane] (Homo sapiens)
T-cell receptor complex [plasma membrane] (Homo sapiens)
T-cell receptor [plasma membrane] (Homo sapiens)
TCR chain alpha [plasma membrane] (Homo sapiens)
TRAC [plasma membrane] (Homo sapiens)
Dephosphorylation of Lck-pY505 by CD45 (Homo sapiens)
Antigen-bearing MHC Class II : TCR complex:CD4:Lck [plasma membrane] (Homo sapiens)
T-cell receptor complex [plasma membrane] (Homo sapiens)
T-cell receptor [plasma membrane] (Homo sapiens)
TCR chain alpha [plasma membrane] (Homo sapiens)
TRAC [plasma membrane] (Homo sapiens)
Antigen-bearing MHC Class II : TCR complex:CD4:p-Lck(Y505) [plasma membrane] (Homo sapiens)
T-cell receptor complex [plasma membrane] (Homo sapiens)
T-cell receptor [plasma membrane] (Homo sapiens)
TCR chain alpha [plasma membrane] (Homo sapiens)
TRAC [plasma membrane] (Homo sapiens)
Inactivation of LCK by PTPN22 (Homo sapiens)
Antigen-bearing MHC Class II : TCR complex:CD4:Lck [plasma membrane] (Homo sapiens)
T-cell receptor complex [plasma membrane] (Homo sapiens)
T-cell receptor [plasma membrane] (Homo sapiens)
TCR chain alpha [plasma membrane] (Homo sapiens)
TRAC [plasma membrane] (Homo sapiens)
Antigen-bearing MHC Class II :TCR complex:CD4: Lck phosphorylated at Tyr394 [plasma membrane] (Homo sapiens)
T-cell receptor complex [plasma membrane] (Homo sapiens)
T-cell receptor [plasma membrane] (Homo sapiens)
TCR chain alpha [plasma membrane] (Homo sapiens)
TRAC [plasma membrane] (Homo sapiens)
Inactivation of Lck by Csk (Homo sapiens)
Antigen-bearing MHC Class II : TCR complex:CD4:Lck [plasma membrane] (Homo sapiens)
T-cell receptor complex [plasma membrane] (Homo sapiens)
T-cell receptor [plasma membrane] (Homo sapiens)
TCR chain alpha [plasma membrane] (Homo sapiens)
TRAC [plasma membrane] (Homo sapiens)
Antigen-bearing MHC Class II : TCR complex:CD4:p-Lck(Y505) [plasma membrane] (Homo sapiens)
T-cell receptor complex [plasma membrane] (Homo sapiens)
T-cell receptor [plasma membrane] (Homo sapiens)
TCR chain alpha [plasma membrane] (Homo sapiens)
TRAC [plasma membrane] (Homo sapiens)
Phosphorylation of ITAM motifs in CD3 complexes (Homo sapiens)
Antigen-bearing MHC Class II :TCR complex:CD4: Lck phosphorylated at Tyr394 [plasma membrane] (Homo sapiens)
T-cell receptor complex [plasma membrane] (Homo sapiens)
T-cell receptor [plasma membrane] (Homo sapiens)
TCR chain alpha [plasma membrane] (Homo sapiens)
TRAC [plasma membrane] (Homo sapiens)
Antigen-bearing MHC Class II: TCR with phosphorylated ITAMs:CD4 [plasma membrane] (Homo sapiens)
T-cell receptor complex with phosphorylated ITAMs [plasma membrane] (Homo sapiens)
T-cell receptor [plasma membrane] (Homo sapiens)
TCR chain alpha [plasma membrane] (Homo sapiens)
TRAC [plasma membrane] (Homo sapiens)
Translocation of ZAP-70 to Immunological synapse (Homo sapiens)
Activation of ZAP-70 (Homo sapiens)
Activated ZAP-70 [plasma membrane] (Homo sapiens)
Antigen-bearing MHC Class II: TCR with phosphorylated ITAMs:CD4 [plasma membrane] (Homo sapiens)
T-cell receptor complex with phosphorylated ITAMs [plasma membrane] (Homo sapiens)
T-cell receptor [plasma membrane] (Homo sapiens)
TCR chain alpha [plasma membrane] (Homo sapiens)
TRAC [plasma membrane] (Homo sapiens)
phospho tyrosine ZAP-70 [plasma membrane] (Homo sapiens)
Antigen-bearing MHC Class II: TCR with phosphorylated ITAMs:CD4 [plasma membrane] (Homo sapiens)
T-cell receptor complex with phosphorylated ITAMs [plasma membrane] (Homo sapiens)
T-cell receptor [plasma membrane] (Homo sapiens)
TCR chain alpha [plasma membrane] (Homo sapiens)
TRAC [plasma membrane] (Homo sapiens)
PTPN22 dephosphorylates ZAP70 (Homo sapiens)
ZAP-70 bound to phosphorylated ITAM motifs [plasma membrane] (Homo sapiens)
Antigen-bearing MHC Class II: TCR with phosphorylated ITAMs:CD4 [plasma membrane] (Homo sapiens)
T-cell receptor complex with phosphorylated ITAMs [plasma membrane] (Homo sapiens)
T-cell receptor [plasma membrane] (Homo sapiens)
TCR chain alpha [plasma membrane] (Homo sapiens)
TRAC [plasma membrane] (Homo sapiens)
phospho tyrosine ZAP-70 [plasma membrane] (Homo sapiens)
Antigen-bearing MHC Class II: TCR with phosphorylated ITAMs:CD4 [plasma membrane] (Homo sapiens)
T-cell receptor complex with phosphorylated ITAMs [plasma membrane] (Homo sapiens)
T-cell receptor [plasma membrane] (Homo sapiens)
TCR chain alpha [plasma membrane] (Homo sapiens)
TRAC [plasma membrane] (Homo sapiens)
Phosphorylation of ZAP-70 by Lck (Homo sapiens)
Antigen-bearing MHC Class II :TCR complex:CD4: Lck phosphorylated at Tyr394 [plasma membrane] (Homo sapiens)
T-cell receptor complex [plasma membrane] (Homo sapiens)
T-cell receptor [plasma membrane] (Homo sapiens)
TCR chain alpha [plasma membrane] (Homo sapiens)
TRAC [plasma membrane] (Homo sapiens)
ZAP-70 bound to phosphorylated ITAM motifs [plasma membrane] (Homo sapiens)
Antigen-bearing MHC Class II: TCR with phosphorylated ITAMs:CD4 [plasma membrane] (Homo sapiens)
T-cell receptor complex with phosphorylated ITAMs [plasma membrane] (Homo sapiens)
T-cell receptor [plasma membrane] (Homo sapiens)
TCR chain alpha [plasma membrane] (Homo sapiens)
TRAC [plasma membrane] (Homo sapiens)
phospho tyrosine ZAP-70 [plasma membrane] (Homo sapiens)
Antigen-bearing MHC Class II: TCR with phosphorylated ITAMs:CD4 [plasma membrane] (Homo sapiens)
T-cell receptor complex with phosphorylated ITAMs [plasma membrane] (Homo sapiens)
T-cell receptor [plasma membrane] (Homo sapiens)
TCR chain alpha [plasma membrane] (Homo sapiens)
TRAC [plasma membrane] (Homo sapiens)
Recruitment of ZAP-70 to phosphorylated ITAMs (Homo sapiens)
Antigen-bearing MHC Class II: TCR with phosphorylated ITAMs:CD4 [plasma membrane] (Homo sapiens)
T-cell receptor complex with phosphorylated ITAMs [plasma membrane] (Homo sapiens)
T-cell receptor [plasma membrane] (Homo sapiens)
TCR chain alpha [plasma membrane] (Homo sapiens)
TRAC [plasma membrane] (Homo sapiens)
ZAP-70 bound to phosphorylated ITAM motifs [plasma membrane] (Homo sapiens)
Antigen-bearing MHC Class II: TCR with phosphorylated ITAMs:CD4 [plasma membrane] (Homo sapiens)
T-cell receptor complex with phosphorylated ITAMs [plasma membrane] (Homo sapiens)
T-cell receptor [plasma membrane] (Homo sapiens)
TCR chain alpha [plasma membrane] (Homo sapiens)
TRAC [plasma membrane] (Homo sapiens)
External Reference Information
External Reference
UniProt:P01848 TRAC
Gene Names
TRAC, TCRA
Chain
chain:1-140
Reference Genes
HGNC:12029 TRAC
OMIM:186880 TRAC
UCSC:P01848 TRAC
Participates
as a member of
TCR chain alpha [plasma membrane] (Homo sapiens)
Inferred To
TRAC [plasma membrane]
(Bos taurus)
TRAC [plasma membrane]
(Mus musculus)
Cross References
OpenTargets
ENSG00000277734
HPA
ENSG00000277734-TRAC
PRO
P01848
Pharos - Targets
P01848
Orphanet
TRAC
GlyGen
P01848
PDB
7FJF
,
4X6C
,
3O4L
,
4ONH
,
4WW1
,
7RYN
,
5HHO
,
4UDU
,
3SDA
,
2PYF
,
7RYL
,
3TVM
,
5KS9
,
5C0C
,
2VLJ
,
2IAN
,
3SCM
,
5EU6
,
3QEU
,
6DKP
,
6JXR
,
3HG1
,
3ARE
,
2PO6
,
4JRY
,
4JFF
,
4Y16
,
2CDG
,
5KSB
,
4MVB
,
7T2C
,
2BNQ
,
2EYS
,
5C09
,
4G8E
,
3ARB
,
3FFC
,
7FJD
,
4X6D
,
4IRS
,
7T2D
,
3SDX
,
4WW2
,
7RYM
,
1AO7
,
2PYE
,
4PRH
,
7RYO
,
2VLK
,
2F54
,
5C0B
,
2ESV
,
2IAM
,
3QEQ
,
5BRZ
,
4P4K
,
2P5W
,
3SDC
,
3T0E
,
3ARF
,
2AK4
,
1BD2
,
5HYJ
,
1QSF
,
5KSA
,
2BNU
,
2P5E
,
2EYR
,
5C08
,
4C56
,
3KPR
,
3DXA
,
1J8H
,
7T2B
,
3PWP
,
3KXF
,
1OGA
,
1ZGL
,
1QRN
,
7NDT
,
2VLM
,
1MI5
,
4Y4F
,
4PRI
,
3SJV
,
4Y4K
,
3SKN
,
2GJ6
,
4Y4H
,
5JZI
,
4ZDH
,
4N0C
,
4JFH
,
4JFD
,
3ARG
,
2CDF
,
1KGC
,
2XN9
,
1FYT
,
3QDM
,
2EYT
,
4WWK
,
3QDG
,
3O9W
,
5C07
,
3QJF
,
4X6B
,
7FJE
,
4G8F
,
3O8X
,
3D39
,
3QIB
,
3O6F
,
4N5E
,
4MXQ
,
5FKA
,
4APQ
,
1YMM
,
3KPS
,
2VLR
,
2F53
,
2IAL
,
4UDT
,
5HHM
,
3TN0
,
5BS0
,
4NHU
,
4PRP
,
3ARD
,
4JFE
,
3HE7
,
4JRX
,
3GSN
,
3QUX
,
5C0A
,
2BNR
,
2XNA
,
5NQK
,
3DX9
,
4Y2D
,
5FK9
,
3QDJ
,
3SDD
,
2NX5
Interactors (2)
Accession
#Entities
Entities
Confidence Score
Evidence (IntAct)
UniProt:Q13572 ITPK1
1
ITPK1 [cytosol]
(R-HSA-994132)
0.527
2
UniProt:Q09328 MGAT5
1
MGAT5 [Golgi membrane]
(R-HSA-975896)
0.527
2
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