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CD247-1 [plasma membrane]
Stable Identifier
R-HSA-198166
Type
Genes and Transcripts [EntityWithAccessionedSequence]
Species
Homo sapiens
Compartment
plasma membrane
Synonyms
CD3 zeta (CD3 zeta isoform 1), T-cell surface glycoprotein CD3 zeta chain, CD3Z_HUMAN, T Cell Receptor zeta chain, CD247 isoform 1
Icon
Locations in the PathwayBrowser
Expand all
Disease (Homo sapiens)
Infectious disease (Homo sapiens)
Parasitic Infection Pathways (Homo sapiens)
Leishmania infection (Homo sapiens)
Leishmania parasite growth and survival (Homo sapiens)
Anti-inflammatory response favouring Leishmania parasite infection (Homo sapiens)
FCGR3A-mediated IL10 synthesis (Homo sapiens)
Opsonized leishmania amastigote binds FCGR3 (Homo sapiens)
FCGRIIIA:CD3G/CD3Z dimers [plasma membrane] (Homo sapiens)
CD3G/CD3Z dimers [plasma membrane] (Homo sapiens)
CD3G:CD3Z heterodimer [plasma membrane] (Homo sapiens)
CD247-1 [plasma membrane] (Homo sapiens)
CD3Z homodimer [plasma membrane] (Homo sapiens)
CD247-1 [plasma membrane] (Homo sapiens)
IgG:Lma antigens:FCGR3A:CD3 dimers [plasma membrane] (Homo sapiens)
FCGRIIIA:CD3G/CD3Z dimers [plasma membrane] (Homo sapiens)
CD3G/CD3Z dimers [plasma membrane] (Homo sapiens)
CD3G:CD3Z heterodimer [plasma membrane] (Homo sapiens)
CD247-1 [plasma membrane] (Homo sapiens)
CD3Z homodimer [plasma membrane] (Homo sapiens)
CD247-1 [plasma membrane] (Homo sapiens)
Src phosphorylates CD3 dimers in IgG:Lma antigens:FCGR3A:CD3 dimers (Homo sapiens)
IgG:Lma antigens:FCGR3A:CD3 dimers [plasma membrane] (Homo sapiens)
FCGRIIIA:CD3G/CD3Z dimers [plasma membrane] (Homo sapiens)
CD3G/CD3Z dimers [plasma membrane] (Homo sapiens)
CD3G:CD3Z heterodimer [plasma membrane] (Homo sapiens)
CD247-1 [plasma membrane] (Homo sapiens)
CD3Z homodimer [plasma membrane] (Homo sapiens)
CD247-1 [plasma membrane] (Homo sapiens)
Parasite infection (Homo sapiens)
Leishmania phagocytosis (Homo sapiens)
FCGR3A-mediated phagocytosis (Homo sapiens)
IgG:Lma antigens binds FCGR3A:CD3 dimers (Homo sapiens)
FCGRIIIA:CD3G/CD3Z dimers [plasma membrane] (Homo sapiens)
CD3G/CD3Z dimers [plasma membrane] (Homo sapiens)
CD3G:CD3Z heterodimer [plasma membrane] (Homo sapiens)
CD247-1 [plasma membrane] (Homo sapiens)
CD3Z homodimer [plasma membrane] (Homo sapiens)
CD247-1 [plasma membrane] (Homo sapiens)
IgG:Lma antigens:FCGR3A:CD3 dimers [plasma membrane] (Homo sapiens)
FCGRIIIA:CD3G/CD3Z dimers [plasma membrane] (Homo sapiens)
CD3G/CD3Z dimers [plasma membrane] (Homo sapiens)
CD3G:CD3Z heterodimer [plasma membrane] (Homo sapiens)
CD247-1 [plasma membrane] (Homo sapiens)
CD3Z homodimer [plasma membrane] (Homo sapiens)
CD247-1 [plasma membrane] (Homo sapiens)
Src phosphorylates CD3 dimers in IgG:Lma antigens:FCGR3A:CD3 dimers (Homo sapiens)
IgG:Lma antigens:FCGR3A:CD3 dimers [plasma membrane] (Homo sapiens)
FCGRIIIA:CD3G/CD3Z dimers [plasma membrane] (Homo sapiens)
CD3G/CD3Z dimers [plasma membrane] (Homo sapiens)
CD3G:CD3Z heterodimer [plasma membrane] (Homo sapiens)
CD247-1 [plasma membrane] (Homo sapiens)
CD3Z homodimer [plasma membrane] (Homo sapiens)
CD247-1 [plasma membrane] (Homo sapiens)
Viral Infection Pathways (Homo sapiens)
HIV Infection (Homo sapiens)
Host Interactions of HIV factors (Homo sapiens)
The role of Nef in HIV-1 replication and disease pathogenesis (Homo sapiens)
Nef and signal transduction (Homo sapiens)
Nef mediated activation of the T-cell receptor (Homo sapiens)
CD247-1 [plasma membrane] (Homo sapiens)
Nef:T cell Receptor zeta:Lipid Raft: Pak 2 Complex [plasma membrane] (Homo sapiens)
CD247-1 [plasma membrane] (Homo sapiens)
Immune System (Homo sapiens)
Adaptive Immune System (Homo sapiens)
Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell (Homo sapiens)
CMVPP65 binds NCR3 (Homo sapiens)
CMVPP65:NCR3:FCRG3A:CD3Z dimer [plasma membrane] (Homo sapiens)
NCR3:FCRG1A:CD3Z dimer [plasma membrane] (Homo sapiens)
FCRG1A:CD3Z dimer [plasma membrane] (Homo sapiens)
CD3Z homodimer [plasma membrane] (Homo sapiens)
CD247-1 [plasma membrane] (Homo sapiens)
NCR3:FCRG1A:CD3Z dimer [plasma membrane] (Homo sapiens)
FCRG1A:CD3Z dimer [plasma membrane] (Homo sapiens)
CD3Z homodimer [plasma membrane] (Homo sapiens)
CD247-1 [plasma membrane] (Homo sapiens)
NCR3LG1 binds NCR3 (Homo sapiens)
NCR3:FCRG1A:CD3Z dimer [plasma membrane] (Homo sapiens)
FCRG1A:CD3Z dimer [plasma membrane] (Homo sapiens)
CD3Z homodimer [plasma membrane] (Homo sapiens)
CD247-1 [plasma membrane] (Homo sapiens)
NCR3LG1:NCR3:FCRG3A:CD3Z dimer [plasma membrane] (Homo sapiens)
NCR3:FCRG1A:CD3Z dimer [plasma membrane] (Homo sapiens)
FCRG1A:CD3Z dimer [plasma membrane] (Homo sapiens)
CD3Z homodimer [plasma membrane] (Homo sapiens)
CD247-1 [plasma membrane] (Homo sapiens)
TCR binds microbial lipid-based antigen via CD1 (Homo sapiens)
CD1:B2M:microbial lipid:TCR [plasma membrane] (Homo sapiens)
T-cell receptor complex [plasma membrane] (Homo sapiens)
CD247-1 [plasma membrane] (Homo sapiens)
T-cell receptor complex [plasma membrane] (Homo sapiens)
CD247-1 [plasma membrane] (Homo sapiens)
TCR binds self-lipid-based antigen via CD1 (Homo sapiens)
CD1:B2M:self-lipid:TCR [plasma membrane] (Homo sapiens)
T-cell receptor complex [plasma membrane] (Homo sapiens)
CD247-1 [plasma membrane] (Homo sapiens)
T-cell receptor complex [plasma membrane] (Homo sapiens)
CD247-1 [plasma membrane] (Homo sapiens)
TCR complex interacts with peptide antigen-presenting MHC Class I (Homo sapiens)
T-cell receptor complex with CD8 [plasma membrane] (Homo sapiens)
T-cell receptor complex [plasma membrane] (Homo sapiens)
CD247-1 [plasma membrane] (Homo sapiens)
TCR interacting with antigen-bearing MHC Class I [plasma membrane] (Homo sapiens)
T-cell receptor complex with CD8 [plasma membrane] (Homo sapiens)
T-cell receptor complex [plasma membrane] (Homo sapiens)
CD247-1 [plasma membrane] (Homo sapiens)
viral HA binds NCRI (Homo sapiens)
NCR1:FCRG1A:CD3Z dimer [plasma membrane] (Homo sapiens)
FCRG1A:CD3Z dimer [plasma membrane] (Homo sapiens)
CD3Z homodimer [plasma membrane] (Homo sapiens)
CD247-1 [plasma membrane] (Homo sapiens)
NCR1:FCRG1A:CD3Z dimer:Hemagglutinin [plasma membrane] (Homo sapiens)
NCR1:FCRG1A:CD3Z dimer [plasma membrane] (Homo sapiens)
FCRG1A:CD3Z dimer [plasma membrane] (Homo sapiens)
CD3Z homodimer [plasma membrane] (Homo sapiens)
CD247-1 [plasma membrane] (Homo sapiens)
Regulation of T cell activation by CD28 family (Homo sapiens)
Co-inhibition by PD-1 (Homo sapiens)
Dephosphorylation of CD3-zeta by PD-1 bound phosphatases (Homo sapiens)
Antigen-bearing MHC Class II: TCR with dephosphorylated CD3 zeta chain:CD4 [plasma membrane] (Homo sapiens)
T-cell receptor complex with dephosphorylated CD3 zeta chain [plasma membrane] (Homo sapiens)
CD247-1 [plasma membrane] (Homo sapiens)
TCR signaling (Homo sapiens)
Downstream TCR signaling (Homo sapiens)
Change of PKC theta conformation (Homo sapiens)
Antigen-bearing MHC Class II :TCR complex:CD4: Lck phosphorylated at Tyr394 [plasma membrane] (Homo sapiens)
T-cell receptor complex [plasma membrane] (Homo sapiens)
CD247-1 [plasma membrane] (Homo sapiens)
Phosphorylation of CD3 and TCR zeta chains (Homo sapiens)
Activation of Lck (Homo sapiens)
Antigen-bearing MHC Class II : TCR complex:CD4:Lck [plasma membrane] (Homo sapiens)
T-cell receptor complex [plasma membrane] (Homo sapiens)
CD247-1 [plasma membrane] (Homo sapiens)
Antigen-bearing MHC Class II :TCR complex:CD4: Lck phosphorylated at Tyr394 [plasma membrane] (Homo sapiens)
T-cell receptor complex [plasma membrane] (Homo sapiens)
CD247-1 [plasma membrane] (Homo sapiens)
Dephosphorylation of Lck-pY505 by CD45 (Homo sapiens)
Antigen-bearing MHC Class II : TCR complex:CD4:Lck [plasma membrane] (Homo sapiens)
T-cell receptor complex [plasma membrane] (Homo sapiens)
CD247-1 [plasma membrane] (Homo sapiens)
Antigen-bearing MHC Class II : TCR complex:CD4:p-Lck(Y505) [plasma membrane] (Homo sapiens)
T-cell receptor complex [plasma membrane] (Homo sapiens)
CD247-1 [plasma membrane] (Homo sapiens)
Inactivation of LCK by PTPN22 (Homo sapiens)
Antigen-bearing MHC Class II : TCR complex:CD4:Lck [plasma membrane] (Homo sapiens)
T-cell receptor complex [plasma membrane] (Homo sapiens)
CD247-1 [plasma membrane] (Homo sapiens)
Antigen-bearing MHC Class II :TCR complex:CD4: Lck phosphorylated at Tyr394 [plasma membrane] (Homo sapiens)
T-cell receptor complex [plasma membrane] (Homo sapiens)
CD247-1 [plasma membrane] (Homo sapiens)
Inactivation of Lck by Csk (Homo sapiens)
Antigen-bearing MHC Class II : TCR complex:CD4:Lck [plasma membrane] (Homo sapiens)
T-cell receptor complex [plasma membrane] (Homo sapiens)
CD247-1 [plasma membrane] (Homo sapiens)
Antigen-bearing MHC Class II : TCR complex:CD4:p-Lck(Y505) [plasma membrane] (Homo sapiens)
T-cell receptor complex [plasma membrane] (Homo sapiens)
CD247-1 [plasma membrane] (Homo sapiens)
Phosphorylation of ITAM motifs in CD3 complexes (Homo sapiens)
Antigen-bearing MHC Class II :TCR complex:CD4: Lck phosphorylated at Tyr394 [plasma membrane] (Homo sapiens)
T-cell receptor complex [plasma membrane] (Homo sapiens)
CD247-1 [plasma membrane] (Homo sapiens)
Translocation of ZAP-70 to Immunological synapse (Homo sapiens)
Phosphorylation of ZAP-70 by Lck (Homo sapiens)
Antigen-bearing MHC Class II :TCR complex:CD4: Lck phosphorylated at Tyr394 [plasma membrane] (Homo sapiens)
T-cell receptor complex [plasma membrane] (Homo sapiens)
CD247-1 [plasma membrane] (Homo sapiens)
Innate Immune System (Homo sapiens)
Fcgamma receptor (FCGR) dependent phagocytosis (Homo sapiens)
FCGR activation (Homo sapiens)
Cross-linking of FCGRIIIA with IgG-coated Ag (Homo sapiens)
FCGRIIIA:CD3G/CD3Z dimers [plasma membrane] (Homo sapiens)
CD3G/CD3Z dimers [plasma membrane] (Homo sapiens)
CD3G:CD3Z heterodimer [plasma membrane] (Homo sapiens)
CD247-1 [plasma membrane] (Homo sapiens)
CD3Z homodimer [plasma membrane] (Homo sapiens)
CD247-1 [plasma membrane] (Homo sapiens)
IgG-Ag:FCGRIIIA:CD3G/CD3Z dimers [plasma membrane] (Homo sapiens)
FCGRIIIA:CD3G/CD3Z dimers [plasma membrane] (Homo sapiens)
CD3G/CD3Z dimers [plasma membrane] (Homo sapiens)
CD3G:CD3Z heterodimer [plasma membrane] (Homo sapiens)
CD247-1 [plasma membrane] (Homo sapiens)
CD3Z homodimer [plasma membrane] (Homo sapiens)
CD247-1 [plasma membrane] (Homo sapiens)
Sequestering and phosphorylation Fc gamma receptors in the lipid rafts (Homo sapiens)
clustered IgG-Ag:FCGRs [plasma membrane] (Homo sapiens)
FCGRs [plasma membrane] (Homo sapiens)
FCGRIIIA:CD3G/CD3Z dimers [plasma membrane] (Homo sapiens)
CD3G/CD3Z dimers [plasma membrane] (Homo sapiens)
CD3G:CD3Z heterodimer [plasma membrane] (Homo sapiens)
CD247-1 [plasma membrane] (Homo sapiens)
CD3Z homodimer [plasma membrane] (Homo sapiens)
CD247-1 [plasma membrane] (Homo sapiens)
External Reference Information
External Reference
UniProt:P20963-1 CD247
Gene Names
CD247, CD3Z, T3Z, TCRZ
Other Identifiers
11725455_at
16695994
210031_PM_at
210031_at
234462_PM_at
234462_at
2442596
2442597
2442598
2442599
2442600
2442605
2442606
2442607
2442608
2442609
2442610
2442611
2442612
2442613
2442614
2442615
2442616
2442617
2442618
2442619
2442620
2442621
2442622
2442623
2442624
2442625
2442626
2442627
2442633
2442634
2442635
2442636
2442637
2442674
2442684
2442685
2442686
2442687
37078_at
7922040
919
A_23_P34676
A_23_P46070
A_33_P3286873
GE58232
GO:0002250
GO:0002376
GO:0004888
GO:0005515
GO:0005737
GO:0005794
GO:0005886
GO:0007166
GO:0016020
GO:0033001
GO:0038094
GO:0042101
GO:0042105
GO:0042106
GO:0042802
GO:0042803
GO:0043226
GO:0046629
GO:0046631
GO:0046982
GO:0050852
GO:0051259
GO:0060089
GO:0065003
GO:0098797
GO:1990782
GO:2000010
HMNXSV003010025
HMNXSV003049359
Hs.283402.1.S1_3p_at
ILMN_1676924
J04132_at
S94421_at
TC01003479.hg
g623041_3p_at
Participates
as a component of
Nef:T cell Receptor zeta:Lipid Raft: Pak 2 Complex [plasma membrane] (Homo sapiens)
T-cell receptor complex with dephosphorylated CD3 zeta chain [plasma membrane] (Homo sapiens)
CD3G:CD3Z heterodimer [plasma membrane] (Homo sapiens)
CD3Z homodimer [plasma membrane] (Homo sapiens)
T-cell receptor complex [plasma membrane] (Homo sapiens)
as an input of
Nef mediated activation of the T-cell receptor (Homo sapiens)
Other forms of this molecule
p-6Y-CD247 [plasma membrane]
Inferred To
CD247 [plasma membrane]
(Bos taurus)
CD247 [plasma membrane]
(Canis familiaris)
CD247 [plasma membrane]
(Sus scrofa)
Cd247 [plasma membrane]
(Mus musculus)
Cd247 [plasma membrane]
(Rattus norvegicus)
CD247-1 [plasma membrane]
(Gallus gallus)
Cross References
RefSeq
NP_000725.1
,
NP_932170.1
Guide to Pharmacology - Targets
3142
OpenTargets
ENSG00000198821
ENSEMBL
ENST00000392122
,
ENST00000362089
,
ENSP00000375969
,
ENSP00000354782
HPA
ENSG00000198821-CD247
PRO
P20963
Pharos - Targets
P20963
Orphanet
CD247
PDB
8YC0
,
8WXE
,
7PHR
,
7FJD
,
7FJF
,
8ES7
,
8ES9
,
8J8I
,
8JCB
,
4XZ1
,
1TCE
,
8ES8
,
3IOZ
,
7FJE
,
3IK5
,
1YGR
,
6JXR
,
2HAC
,
8WY0
,
8WYI
,
2OQ1
,
8JC0
Interactors (4)
Accession
#Entities
Entities
Confidence Score
Evidence (IntAct)
UniProt:P43403 ZAP70
3
p-Y315,Y493-ZAP70 [cytosol]
(R-HSA-202252)
p-Y493-ZAP70 [cytosol]
(R-HSA-202368)
ZAP70 [cytosol]
(R-HSA-202397)
0.918
23
UniProt:P49407 ARRB1
6
ARRB1 [cytosol]
(R-HSA-264470)
PolyUb-ARRB1 [cytosol]
(R-HSA-6783186)
ARRB1 [endocytic vesicle membrane]
(R-HSA-9910882)
ARRB1 [lysosomal membrane]
(R-HSA-432701)
ARRB1 [Golgi membrane]
(R-HSA-350831)
ARRB1 [cytoplasmic vesicle membrane]
(R-HSA-351187)
0.644
9
UniProt:Q9Y2R2 PTPN22
1
PTPN22 [cytosol]
(R-HSA-8852205)
0.632
4
UniProt:P06239 LCK
4
LCK [cytosol]
(R-HSA-167609)
p-Y394-LCK [cytosol]
(R-HSA-202308)
p-Y505-LCK [plasma membrane]
(R-HSA-202159)
p-Y394-LCK [plasma membrane]
(R-HSA-8857940)
0.609
2
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