Reactome | CD40-1 [plasma membrane]

CD40-1 [plasma membrane]

Stable Identifier

R-HSA-198117

Type

Genes and Transcripts [EntityWithAccessionedSequence]

Species

Homo sapiens

Compartment

plasma membrane

Synonyms

Tumor necrosis factor receptor superfamily member 5, TNR5_HUMAN, TNFRSF5, CD40 isoform 1

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Locations in the PathwayBrowser

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Immune System (Homo sapiens)

- Adaptive Immune System (Homo sapiens)
  - Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell (Homo sapiens)
    - CD40L binds CD40 (Homo sapiens)
      - CD40 trimer [plasma membrane] (Homo sapiens)
        
        CD40-1 [plasma membrane] (Homo sapiens)
      - CD40:CD40L trimer [plasma membrane] (Homo sapiens)
        
        CD40 trimer [plasma membrane] (Homo sapiens)
        
        CD40-1 [plasma membrane] (Homo sapiens)
- Cytokine Signaling in Immune system (Homo sapiens)
  - TNFR2 non-canonical NF-kB pathway (Homo sapiens)
    - K63polyUb-cIAP1,2 ubiquitinates TRAF3 (Homo sapiens)
      - TNFSF:TNFRSF heterotrimer:K63polyUb-cIAP1,2:TRAF2:TRAF3:NIK [plasma membrane] (Homo sapiens)
        
        TNFA:TNFR2,BAFF:BAFFR,TWEAK:Fn14,Lymphotoxin:LTBR,RANKL:RANK,CD40L:CD40 [plasma membrane] (Homo sapiens)
        
        CD40:CD40L trimer [plasma membrane] (Homo sapiens)
        
        CD40 trimer [plasma membrane] (Homo sapiens)
        
        CD40-1 [plasma membrane] (Homo sapiens)
      - TNFSF:TNFRSF heterotrimer:TRAF2:K63polyUb-cIAP1,2:K48polyUb-TRAF3:NIK [plasma membrane] (Homo sapiens)
        
        TNFA:TNFR2,BAFF:BAFFR,TWEAK:Fn14,Lymphotoxin:LTBR,RANKL:RANK,CD40L:CD40 [plasma membrane] (Homo sapiens)
        
        CD40:CD40L trimer [plasma membrane] (Homo sapiens)
        
        CD40 trimer [plasma membrane] (Homo sapiens)
        
        CD40-1 [plasma membrane] (Homo sapiens)
    - Protesomal degradation of K48polyUb-TRAF3 (Homo sapiens)
      - TNFA:TNFR2,BAFF:BAFFR,TWEAK:Fn14,Lymphotoxin:LTBR,RANKL:RANK,CD40L:CD40 [plasma membrane] (Homo sapiens)
        
        CD40:CD40L trimer [plasma membrane] (Homo sapiens)
        
        CD40 trimer [plasma membrane] (Homo sapiens)
        
        CD40-1 [plasma membrane] (Homo sapiens)
      - TNFSF:TNFRSF heterotrimer:TRAF2:K63polyUb-cIAP1,2:K48polyUb-TRAF3:NIK [plasma membrane] (Homo sapiens)
        
        TNFA:TNFR2,BAFF:BAFFR,TWEAK:Fn14,Lymphotoxin:LTBR,RANKL:RANK,CD40L:CD40 [plasma membrane] (Homo sapiens)
        
        CD40:CD40L trimer [plasma membrane] (Homo sapiens)
        
        CD40 trimer [plasma membrane] (Homo sapiens)
        
        CD40-1 [plasma membrane] (Homo sapiens)
    - TNF receptor superfamily (TNFSF) members mediating non-canonical NF-kB pathway (Homo sapiens)
      - CD40L binds CD40 (Homo sapiens)
        
        CD40 trimer [plasma membrane] (Homo sapiens)
        
        CD40-1 [plasma membrane] (Homo sapiens)
        
        CD40:CD40L trimer [plasma membrane] (Homo sapiens)
        
        CD40 trimer [plasma membrane] (Homo sapiens)
        
        CD40-1 [plasma membrane] (Homo sapiens)
      - TRAF2:TRAF1:cIAP1,2:TRAF3:NIK regulatory complex binds CD40 (Homo sapiens)
        
        CD40:CD40L trimer [plasma membrane] (Homo sapiens)
        
        CD40 trimer [plasma membrane] (Homo sapiens)
        
        CD40-1 [plasma membrane] (Homo sapiens)
        
        CD40:CD40L trimer:cIAP1,2:TRAF2:TRAF3:NIK [plasma membrane] (Homo sapiens)
        
        CD40:CD40L trimer [plasma membrane] (Homo sapiens)
        
        CD40 trimer [plasma membrane] (Homo sapiens)
        
        CD40-1 [plasma membrane] (Homo sapiens)
    - TRAF2 ubiquitinates cIAP1,2 in cIAP1,2:TRAF1:TRAF2:TRAF3:NIK (Homo sapiens)
      - Non-canonical NF-kB initiating TNFRSF memebers [plasma membrane] (Homo sapiens)
        
        CD40:CD40L trimer:cIAP1,2:TRAF2:TRAF3:NIK [plasma membrane] (Homo sapiens)
        
        CD40:CD40L trimer [plasma membrane] (Homo sapiens)
        
        CD40 trimer [plasma membrane] (Homo sapiens)
        
        CD40-1 [plasma membrane] (Homo sapiens)
      - TNFSF:TNFRSF heterotrimer:K63polyUb-cIAP1,2:TRAF2:TRAF3:NIK [plasma membrane] (Homo sapiens)
        
        TNFA:TNFR2,BAFF:BAFFR,TWEAK:Fn14,Lymphotoxin:LTBR,RANKL:RANK,CD40L:CD40 [plasma membrane] (Homo sapiens)
        
        CD40:CD40L trimer [plasma membrane] (Homo sapiens)
        
        CD40 trimer [plasma membrane] (Homo sapiens)
        
        CD40-1 [plasma membrane] (Homo sapiens)
    - cIAP1,2 ubiquitinates NIK in cIAP1,2:TRAF2::TRAF3:NIK (Homo sapiens)
      - TNFSF:TNFRSF heterotrimer:K63polyUb-cIAP1,2:TRAF2:TRAF3:NIK [plasma membrane] (Homo sapiens)
        
        TNFA:TNFR2,BAFF:BAFFR,TWEAK:Fn14,Lymphotoxin:LTBR,RANKL:RANK,CD40L:CD40 [plasma membrane] (Homo sapiens)
        
        CD40:CD40L trimer [plasma membrane] (Homo sapiens)
        
        CD40 trimer [plasma membrane] (Homo sapiens)
        
        CD40-1 [plasma membrane] (Homo sapiens)

External Reference Information

External Reference

UniProt:P25942-1 CD40

Gene Names

CD40, TNFRSF5

Other Identifiers

11731818_a_at

11742282_a_at

205153_PM_s_at

205153_s_at

215346_PM_at

215346_at

35149_at

35150_3p_at

35150_PM_at

35150_at

3887303

3887304

3887307

3887308

3887310

3887311

3887316

3887317

3887324

3887328

3887329

3887330

3887331

3887332

4870417_3p_s_at

8063156

958

A_23_P57036

A_33_P3245439

GE59862

GO:0001934

GO:0002376

GO:0002637

GO:0002768

GO:0003823

GO:0005515

GO:0005576

GO:0005615

GO:0005886

GO:0006310

GO:0006351

GO:0006355

GO:0006874

GO:0006954

GO:0009617

GO:0009897

GO:0009986

GO:0012501

GO:0016020

GO:0019724

GO:0019899

GO:0019904

GO:0023035

GO:0023052

GO:0030168

GO:0030890

GO:0031625

GO:0031667

GO:0032735

GO:0033590

GO:0034341

GO:0035631

GO:0035666

GO:0036018

GO:0036211

GO:0038023

GO:0042060

GO:0042100

GO:0042113

GO:0042531

GO:0042832

GO:0043025

GO:0043123

GO:0043196

GO:0043226

GO:0043231

GO:0043406

GO:0043491

GO:0043536

GO:0043547

GO:0045766

GO:0045944

GO:0048304

GO:0048856

GO:0048870

GO:0050776

GO:0051092

GO:0051607

GO:0055065

GO:0060089

GO:0065003

GO:0070062

GO:0071222

GO:0071260

GO:0071347

GO:0071356

GO:0090037

GO:0098542

GO:1901652

GO:2000353

HMNXSV003049916

Hs.25648.1.S1_3p_x_at

ILMN_1779257

ILMN_2367818

PH_hs_0026562

TC20000365.hg

X60592_at

g4507580_3p_a_at

Participates

as a component of

CD40 trimer [plasma membrane] (Homo sapiens)

Inferred To

CD40-1 [plasma membrane] (Gallus gallus)

cd40 [plasma membrane] (Xenopus tropicalis)

Cd40 [plasma membrane] (Mus musculus)

Cd40 [plasma membrane] (Rattus norvegicus)

CD40 [plasma membrane] (Bos taurus)

CD40 [plasma membrane] (Canis familiaris)

CD40 [plasma membrane] (Sus scrofa)

si:ch211-231h20.3 [plasma membrane] (Danio rerio)

Cross References

RefSeq

NP_690593.1, NP_001309351.1, NP_001289682.1, NP_001241.1

Guide to Pharmacology - Targets

1874

OpenTargets

ENSG00000101017

GeneCards

P25942

HPA

ENSG00000101017-CD40

Ensembl

ENST00000372285, ENST00000372276, ENSP00000361350, ENSG00000101017, ENSP00000361359

ZINC target

P25942

PRO

P25942

Pharos - Targets

P25942

Orphanet

15414

PDB

1D00, 5DMI, 1CZZ, 6FAX, 5DMJ, 1FLL, 7P3I, 3QD6, 1LB6, 5IHL, 6PE8, 6PE9

Interactors (6)

Accession	#Entities	Entities	Confidence Score	Evidence (IntAct)
UniProt:Q12933 TRAF2	5	TRAF2 [nucleoplasm] (R-HSA-8862199) K63polyUb-TRAF2 [nucleoplasm] (R-HSA-8862194) K63polyUb-TRAF2 [cytosol] (R-HSA-8862193) PolyUb-TRAF2 [cytosol] (R-HSA-6782848) TRAF2 [cytosol] (R-HSA-66370)	0.951	18
UniProt:Q9Y4K3 TRAF6	8	K48polyUb-TRAF6 [cytosol] (R-HSA-6783233) PolyUb-TRAF6 [cytosol] (R-HSA-6782845) TRAF6 [endosome membrane] (R-HSA-450272) K63polyUb-TRAF6 [endosome membrane] (R-HSA-450227) TRAF6 [cytosol] (R-HSA-166366) K63polyUb-TRAF6 [cytosol] (R-HSA-2685681) K63polyUb-TRAF6 [plasma membrane] (R-HSA-936980) TRAF6 [plasma membrane] (R-HSA-936955)	0.59	2
UniProt:Q9BRI3 SLC30A2	2	SLC30A2 [endosome membrane] (R-HSA-435363) SLC30A2 [synaptic vesicle membrane] (R-HSA-4084714)	0.556	3
UniProt:P30825 SLC7A1	1	SLC7A1 [plasma membrane] (R-HSA-375771)	0.556	3
UniProt:Q15125 EBP	1	EBP [endoplasmic reticulum membrane] (R-HSA-195697)	0.556	3
UniProt:Q13114 TRAF3	4	TRAF3 R118W [cytosol] (R-HSA-5602321) K48polyUb-TRAF3 [cytosol] (R-HSA-936556) TRAF3 [cytosol] (R-HSA-914241) K63polyUb-TRAF3 [cytosol] (R-HSA-936402)	0.508	3

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