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CD40LG(1-261) [plasma membrane]
Stable Identifier
R-HSA-198113
Type
Protein [EntityWithAccessionedSequence]
Species
Homo sapiens
Compartment
plasma membrane
Synonyms
Tumor necrosis factor ligand superfamily member 5, TNF5_HUMAN, TNFSF5
Icon
Locations in the PathwayBrowser
Expand all
Immune System (Homo sapiens)
Adaptive Immune System (Homo sapiens)
Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell (Homo sapiens)
CD40L binds CD40 (Homo sapiens)
CD40:CD40L trimer [plasma membrane] (Homo sapiens)
CD40LG trimer [plasma membrane] (Homo sapiens)
CD40LG(1-261) [plasma membrane] (Homo sapiens)
CD40LG trimer [plasma membrane] (Homo sapiens)
CD40LG(1-261) [plasma membrane] (Homo sapiens)
Cytokine Signaling in Immune system (Homo sapiens)
TNFR2 non-canonical NF-kB pathway (Homo sapiens)
K63polyUb-cIAP1,2 ubiquitinates TRAF3 (Homo sapiens)
TNFSF:TNFRSF heterotrimer:K63polyUb-cIAP1,2:TRAF2:TRAF3:NIK [plasma membrane] (Homo sapiens)
TNFA:TNFR2,BAFF:BAFFR,TWEAK:Fn14,Lymphotoxin:LTBR,RANKL:RANK,CD40L:CD40 [plasma membrane] (Homo sapiens)
CD40:CD40L trimer [plasma membrane] (Homo sapiens)
CD40LG trimer [plasma membrane] (Homo sapiens)
CD40LG(1-261) [plasma membrane] (Homo sapiens)
TNFSF:TNFRSF heterotrimer:TRAF2:K63polyUb-cIAP1,2:K48polyUb-TRAF3:NIK [plasma membrane] (Homo sapiens)
TNFA:TNFR2,BAFF:BAFFR,TWEAK:Fn14,Lymphotoxin:LTBR,RANKL:RANK,CD40L:CD40 [plasma membrane] (Homo sapiens)
CD40:CD40L trimer [plasma membrane] (Homo sapiens)
CD40LG trimer [plasma membrane] (Homo sapiens)
CD40LG(1-261) [plasma membrane] (Homo sapiens)
Protesomal degradation of K48polyUb-TRAF3 (Homo sapiens)
TNFA:TNFR2,BAFF:BAFFR,TWEAK:Fn14,Lymphotoxin:LTBR,RANKL:RANK,CD40L:CD40 [plasma membrane] (Homo sapiens)
CD40:CD40L trimer [plasma membrane] (Homo sapiens)
CD40LG trimer [plasma membrane] (Homo sapiens)
CD40LG(1-261) [plasma membrane] (Homo sapiens)
TNFSF:TNFRSF heterotrimer:TRAF2:K63polyUb-cIAP1,2:K48polyUb-TRAF3:NIK [plasma membrane] (Homo sapiens)
TNFA:TNFR2,BAFF:BAFFR,TWEAK:Fn14,Lymphotoxin:LTBR,RANKL:RANK,CD40L:CD40 [plasma membrane] (Homo sapiens)
CD40:CD40L trimer [plasma membrane] (Homo sapiens)
CD40LG trimer [plasma membrane] (Homo sapiens)
CD40LG(1-261) [plasma membrane] (Homo sapiens)
TNF receptor superfamily (TNFSF) members mediating non-canonical NF-kB pathway (Homo sapiens)
CD40L binds CD40 (Homo sapiens)
CD40:CD40L trimer [plasma membrane] (Homo sapiens)
CD40LG trimer [plasma membrane] (Homo sapiens)
CD40LG(1-261) [plasma membrane] (Homo sapiens)
CD40LG trimer [plasma membrane] (Homo sapiens)
CD40LG(1-261) [plasma membrane] (Homo sapiens)
TRAF2:TRAF1:cIAP1,2:TRAF3:NIK regulatory complex binds CD40 (Homo sapiens)
CD40:CD40L trimer [plasma membrane] (Homo sapiens)
CD40LG trimer [plasma membrane] (Homo sapiens)
CD40LG(1-261) [plasma membrane] (Homo sapiens)
CD40:CD40L trimer:cIAP1,2:TRAF2:TRAF3:NIK [plasma membrane] (Homo sapiens)
CD40:CD40L trimer [plasma membrane] (Homo sapiens)
CD40LG trimer [plasma membrane] (Homo sapiens)
CD40LG(1-261) [plasma membrane] (Homo sapiens)
TRAF2 ubiquitinates cIAP1,2 in cIAP1,2:TRAF1:TRAF2:TRAF3:NIK (Homo sapiens)
Non-canonical NF-kB initiating TNFRSF memebers [plasma membrane] (Homo sapiens)
CD40:CD40L trimer:cIAP1,2:TRAF2:TRAF3:NIK [plasma membrane] (Homo sapiens)
CD40:CD40L trimer [plasma membrane] (Homo sapiens)
CD40LG trimer [plasma membrane] (Homo sapiens)
CD40LG(1-261) [plasma membrane] (Homo sapiens)
TNFSF:TNFRSF heterotrimer:K63polyUb-cIAP1,2:TRAF2:TRAF3:NIK [plasma membrane] (Homo sapiens)
TNFA:TNFR2,BAFF:BAFFR,TWEAK:Fn14,Lymphotoxin:LTBR,RANKL:RANK,CD40L:CD40 [plasma membrane] (Homo sapiens)
CD40:CD40L trimer [plasma membrane] (Homo sapiens)
CD40LG trimer [plasma membrane] (Homo sapiens)
CD40LG(1-261) [plasma membrane] (Homo sapiens)
cIAP1,2 ubiquitinates NIK in cIAP1,2:TRAF2::TRAF3:NIK (Homo sapiens)
TNFSF:TNFRSF heterotrimer:K63polyUb-cIAP1,2:TRAF2:TRAF3:NIK [plasma membrane] (Homo sapiens)
TNFA:TNFR2,BAFF:BAFFR,TWEAK:Fn14,Lymphotoxin:LTBR,RANKL:RANK,CD40L:CD40 [plasma membrane] (Homo sapiens)
CD40:CD40L trimer [plasma membrane] (Homo sapiens)
CD40LG trimer [plasma membrane] (Homo sapiens)
CD40LG(1-261) [plasma membrane] (Homo sapiens)
External Reference Information
External Reference
UniProt:P29965 CD40LG
Gene Names
CD40LG, CD40L, TNFSF5, TRAP
Chain
chain:1-261, chain:113-261
Reference Genes
BioGPS Gene:959 CD40LG
COSMIC (genes):CD40LG CD40LG
CTD Gene:959 CD40LG
dbSNP Gene:959 CD40LG
ENSEMBL:ENSG00000102245 CD40LG
HGNC:11935 CD40LG
KEGG:hsa:959 CD40LG
Monarch:959 CD40LG
NCBI Gene:959 CD40LG
OMIM:300386 CD40LG
UCSC:P29965 CD40LG
Reference Transcript
RefSeq:NM_000074.2 CD40LG
Other Identifiers
11735105_a_at
11735106_at
17107329
207892_PM_at
207892_at
33945_at
3992581
3992582
3992583
3992584
3992585
3992586
3992587
3992588
3992590
3992591
8170187
959
A_14_P116946
A_23_P62220
A_33_P3250680
D31797_at
GE59946
GO:0002376
GO:0002637
GO:0005102
GO:0005125
GO:0005164
GO:0005174
GO:0005178
GO:0005515
GO:0005576
GO:0005615
GO:0005794
GO:0005886
GO:0006310
GO:0006355
GO:0006954
GO:0006955
GO:0007154
GO:0007155
GO:0007159
GO:0007165
GO:0007229
GO:0009897
GO:0009986
GO:0016020
GO:0023035
GO:0023052
GO:0030154
GO:0030168
GO:0030183
GO:0031295
GO:0032733
GO:0032735
GO:0032753
GO:0042100
GO:0042102
GO:0043066
GO:0043226
GO:0043539
GO:0045190
GO:0048018
GO:0051092
GO:0098772
GO:2000353
HMNXSV003043491
ILMN_1659077
PH_hs_0000074
TC0X000666.hg
g4557432_3p_at
Participates
as a component of
CD40LG trimer [plasma membrane] (Homo sapiens)
Inferred To
CD40LG [plasma membrane]
(Bos taurus)
CD40LG [plasma membrane]
(Canis familiaris)
CD40LG [plasma membrane]
(Gallus gallus)
CD40LG [plasma membrane]
(Sus scrofa)
tnfsf10l4 [plasma membrane]
(Danio rerio)
LOC112445051 [plasma membrane]
(Bos taurus)
cd40lg [plasma membrane]
(Danio rerio)
cd40lg [plasma membrane]
(Xenopus tropicalis)
Homologues of CD40LG(1-261) [plasma membrane]
(Bos taurus)
Homologues of CD40LG(1-261) [plasma membrane]
(Danio rerio)
CD40LG(1-261) [plasma membrane]
(Danio rerio)
Cd40lg [plasma membrane]
(Mus musculus)
Cd40lg [plasma membrane]
(Rattus norvegicus)
Cross References
RefSeq
NP_000065.1
ENSEMBL
ENSP00000359663
,
ENST00000370629
OpenTargets
ENSG00000102245
HPA
ENSG00000102245-CD40LG
PRO
P29965
Pharos - Targets
P29965
GlyGen
P29965
Orphanet
CD40LG
HMDB Protein
HMDBP02163
PDB
6BRB
,
6W9G
,
1ALY
,
1I9R
,
3QD6
,
3LKJ
,
7SGM
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