18094723 |
FBW7 ubiquitin ligase: a tumour suppressor at the crossroads of cell division, growth and differentiation
Welcker, M,
Clurman, BE
|
Nat Rev Cancer |
2008 |
11585921 |
SEL-10 is an inhibitor of notch signaling that targets notch for ubiquitin-mediated protein degradation
Wu, G,
Lyapina, S,
Das, I,
Li, J,
Gurney, M,
Pauley, A,
Chui, I,
Deshaies, RJ,
Kitajewski, J
|
Mol Cell Biol |
2001 |
8001118 |
Groucho is required for Drosophila neurogenesis, segmentation, and sex determination and interacts directly with hairy-related bHLH proteins
Paroush, Z,
Finley RL, Jr,
Kidd, T,
Wainwright, SM,
Ingham, PW,
Brent, R,
Ish-Horowicz, D
|
Cell |
1994 |
11044625 |
Analysis of HeyL expression in wild-type and Notch pathway mutant mouse embryos
Leimeister, C,
Schumacher, N,
Steidl, C,
Gessler, M
|
Mech Dev |
2000 |
15965470 |
DNER acts as a neuron-specific Notch ligand during Bergmann glial development
Eiraku, M,
Tohgo, A,
Ono, K,
Kaneko, M,
Fujishima, K,
Hirano, T,
Kengaku, M
|
Nat Neurosci |
2005 |
12391150 |
p300 and PCAF act cooperatively to mediate transcriptional activation from chromatin templates by notch intracellular domains in vitro
Wallberg, AE,
Pedersen, K,
Lendahl, U,
Roeder, RG
|
Mol Cell Biol |
2002 |
16530044 |
Structural basis for cooperativity in recruitment of MAML coactivators to Notch transcription complexes
Nam, Y,
Sliz, P,
Song, L,
Aster, JC,
Blacklow, SC
|
Cell |
2006 |
12354787 |
The disintegrin/metalloprotease ADAM 10 is essential for Notch signalling but not for alpha-secretase activity in fibroblasts
Hartmann, D,
De Strooper, B,
Serneels, L,
Craessaerts, K,
Herreman, A,
Annaert, W,
Umans, L,
Lübke, T,
Lena Illert, A,
von Figura, K,
Saftig, P
|
Hum Mol Genet |
2002 |
9244301 |
Kuzbanian controls proteolytic processing of Notch and mediates lateral inhibition during Drosophila and vertebrate neurogenesis
Pan, D,
Rubin, GM
|
Cell |
1997 |
16284625 |
Regulation of Notch signalling by non-visual beta-arrestin
Mukherjee, A,
Veraksa, A,
Bauer, A,
Rosse, C,
Camonis, J,
Artavanis-Tsakonas, S
|
Nat Cell Biol |
2005 |
9462510 |
The human homolog of rat Jagged1 expressed by marrow stroma inhibits differentiation of 32D cells through interaction with Notch1
Li, L,
Milner, LA,
Deng, Y,
Iwata, M,
Banta, AB,
Graf, L,
Marcovina, S,
Friedman, C,
Trask, BJ,
Hood, L,
Torok-Storb, B
|
Immunity |
1998 |
16256737 |
Hypoxia requires notch signaling to maintain the undifferentiated cell state
Gustafsson, MV,
Zheng, X,
Pereira, T,
Gradin, K,
Jin, S,
Lundkvist, J,
Ruas, JL,
Poellinger, L,
Lendahl, U,
Bondesson, M
|
Dev Cell |
2005 |
14980219 |
A corepressor/coactivator exchange complex required for transcriptional activation by nuclear receptors and other regulated transcription factors
Perissi, V,
Aggarwal, A,
Glass, CK,
Rose, DW,
Rosenfeld, MG
|
Cell |
2004 |
19726682 |
Metalloprotease ADAM10 is required for Notch1 site 2 cleavage
van Tetering, G,
van Diest, P,
Verlaan, I,
van der Wall, E,
Kopan, R,
Vooijs, M
|
J Biol Chem |
2009 |
9694793 |
A histone deacetylase corepressor complex regulates the Notch signal transduction pathway
Kao, HY,
Ordentlich, P,
Koyano-Nakagawa, N,
Tang, Z,
Downes, M,
Kintner, CR,
Evans, RM,
Kadesch, T
|
Genes Dev |
1998 |
18374649 |
TBL1 and TBLR1 phosphorylation on regulated gene promoters overcomes dual CtBP and NCoR/SMRT transcriptional repression checkpoints
Perissi, V,
Scafoglio, C,
Zhang, J,
Ohgi, KA,
Rose, DW,
Glass, CK,
Rosenfeld, MG
|
Mol Cell |
2008 |
11006133 |
Physical interaction of Delta1, Jagged1, and Jagged2 with Notch1 and Notch3 receptors
Shimizu, K,
Chiba, S,
Saito, T,
Kumano, K,
Hirai, H
|
Biochem Biophys Res Commun |
2000 |
11461910 |
The Notch intracellular domain is ubiquitinated and negatively regulated by the mammalian Sel-10 homolog
Oberg, C,
Li, J,
Pauley, A,
Wolf, E,
Gurney, M,
Lendahl, U
|
J Biol Chem |
2001 |
20972443 |
Structural and mechanistic insights into cooperative assembly of dimeric Notch transcription complexes
Arnett, KL,
Hass, M,
McArthur, DG,
Ilagan, MXG,
Aster, JC,
Kopan, R,
Blacklow, SC
|
Nat Struct Mol Biol |
2010 |
15574878 |
Fringe glycosyltransferases differentially modulate Notch1 proteolysis induced by Delta1 and Jagged1
Yang, LT,
Nichols, JT,
Yao, C,
Manilay, JO,
Robey, EA,
Weinmaster, G
|
Mol Biol Cell |
2005 |
9620803 |
Notch-1 signalling requires ligand-induced proteolytic release of intracellular domain
Schroeter, EH,
Kisslinger, JA,
Kopan, R
|
Nature |
1998 |
8649374 |
The WRPW motif of the hairy-related basic helix-loop-helix repressor proteins acts as a 4-amino-acid transcription repression and protein-protein interaction domain
Fisher, AL,
Ohsako, S,
Caudy, M
|
Mol Cell Biol |
1996 |
10206645 |
A presenilin-1-dependent gamma-secretase-like protease mediates release of Notch intracellular domain
De Strooper, B,
Annaert, W,
Cupers, P,
Saftig, P,
Craessaerts, K,
Mumm, JS,
Schroeter, EH,
Schrijvers, V,
Wolfe, MS,
Ray, WJ,
Goate, A,
Kopan, R
|
Nature |
1999 |
8687460 |
Molecular interaction between TLE1 and the carboxyl-terminal domain of HES-1 containing the WRPW motif
Grbavec, D,
Stifani, S
|
Biochem Biophys Res Commun |
1996 |
15107403 |
The Notch target genes Hey1 and Hey2 are required for embryonic vascular development
Fischer, A,
Schumacher, N,
Maier, M,
Sendtner, M,
Gessler, M
|
Genes Dev |
2004 |
10879540 |
Embryonic lethality in mice homozygous for a processing-deficient allele of Notch1
Huppert, SS,
Le, A,
Schroeter, EH,
Mumm, JS,
Saxena, MT,
Milner, LA,
Kopan, R
|
Nature |
2000 |
18077452 |
Neuralized-like 1 (Neurl1) targeted to the plasma membrane by N-myristoylation regulates the Notch ligand Jagged1
Koutelou, E,
Sato, S,
Tomomori-Sato, C,
Florens, LA,
Swanson, SK,
Washburn, MP,
Kokkinaki, M,
Conaway, RC,
Conaway, JW,
Moschonas, NK
|
J Biol Chem |
2008 |
15652348 |
dlk acts as a negative regulator of Notch1 activation through interactions with specific EGF-like repeats
Baladrón, V,
Ruiz-Hidalgo, MJ,
Nueda, ML,
Díaz-Guerra, MJM,
García-Ramírez, JJ,
Bonvini, E,
Gubina, E,
Laborda, J
|
Exp Cell Res |
2005 |
12530964 |
Mind bomb is a ubiquitin ligase that is essential for efficient activation of Notch signaling by Delta
Itoh, M,
Kim, CH,
Palardy, G,
Oda, T,
Jiang, YJ,
Maust, D,
Yeo, SY,
Lorick, K,
Wright, GJ,
Ariza-McNaughton, L,
Weissman, AM,
Lewis, J,
Chandrasekharappa, SC,
Chitnis, AB
|
Dev Cell |
2003 |
17003037 |
Neuralized-2 regulates a Notch ligand in cooperation with Mind bomb-1
Song, R,
Koo, BK,
Yoon, KJ,
Yoon, MJ,
Yoo, KW,
Kim, HT,
Oh, HJ,
Kim, YY,
Han, JK,
Kim, CH,
Kong, YY
|
J Biol Chem |
2006 |
7566092 |
Signalling downstream of activated mammalian Notch
Jarriault, S,
Brou, C,
Logeat, F,
Schroeter, EH,
Kopan, R,
Israel, A
|
Nature |
1995 |
17114293 |
NOTCH1 directly regulates c-MYC and activates a feed-forward-loop transcriptional network promoting leukemic cell growth
Palomero, T,
Lim, WK,
Odom, DT,
Sulis, ML,
Real, PJ,
Margolin, A,
Barnes, KC,
O'Neil, J,
Neuberg, D,
Weng, AP,
Aster, JC,
Sigaux, F,
Soulier, J,
Look, AT,
Young, RA,
Califano, A,
Ferrando, AA
|
Proc Natl Acad Sci U S A |
2006 |
11740940 |
Drosophila neuralized is a ubiquitin ligase that promotes the internalization and degradation of delta
Lai, EC,
Deblandre, GA,
Kintner, C,
Rubin, GM
|
Dev Cell |
2001 |
19567869 |
Numb regulates post-endocytic trafficking and degradation of Notch1
McGill, MA,
Dho, SE,
Weinmaster, G,
McGlade, CJ
|
J Biol Chem |
2009 |
18628966 |
AIP4/Itch regulates Notch receptor degradation in the absence of ligand
Chastagner, P,
Israel, A,
Brou, C
|
PLoS One |
2008 |
10964718 |
Comparative analysis of the human and mouse Hey1 promoter: Hey genes are new Notch target genes
Maier, MM,
Gessler, M
|
Biochem Biophys Res Commun |
2000 |
9590294 |
Human deltex is a conserved regulator of Notch signalling
Matsuno, K,
Eastman, D,
Mitsiades, T,
Quinn, AM,
Carcanciu, ML,
Ordentlich, P,
Kadesch, T,
Artavanis-Tsakonas, S
|
Nat Genet |
1998 |
11226752 |
Murine homologs of deltex define a novel gene family involved in vertebrate Notch signaling and neurogenesis
Kishi, N,
Tang, Z,
Maeda, Y,
Hirai, A,
Mo, R,
Ito, M,
Suzuki, S,
Nakao, K,
Kinoshita, T,
Kadesch, T,
Hui, C,
Artavanis-Tsakonas, S,
Okano, H,
Matsuno, K
|
Int J Dev Neurosci |
2001 |
17028573 |
Itch/AIP4 mediates Deltex degradation through the formation of K29-linked polyubiquitin chains
Chastagner, P,
Israel, A,
Brou, C
|
EMBO Rep |
2006 |
15824097 |
Mind bomb-2 is an E3 ligase for Notch ligand
Koo, BK,
Yoon, KJ,
Yoo, KW,
Lim, HS,
Song, R,
So, JH,
Kim, CH,
Kong, YY
|
J Biol Chem |
2005 |
10882063 |
A novel proteolytic cleavage involved in Notch signaling: the role of the disintegrin-metalloprotease TACE
Brou, C,
Logeat, F,
Gupta, N,
Bessia, C,
LeBail, O,
Doedens, JR,
Cumano, A,
Roux, P,
Black, RA,
Israel, A
|
Mol Cell |
2000 |
15546612 |
Mastermind recruits CycC:CDK8 to phosphorylate the Notch ICD and coordinate activation with turnover
Fryer, CJ,
White, JB,
Jones, KA
|
Mol Cell |
2004 |
19524514 |
The notch ligands Dll4 and Jagged1 have opposing effects on angiogenesis
Benedito, R,
Roca, C,
Sörensen, I,
Adams, S,
Gossler, A,
Fruttiger, M,
Adams, RH
|
Cell |
2009 |
14567914 |
F3/contactin acts as a functional ligand for Notch during oligodendrocyte maturation
Hu, QD,
Ang, BT,
Karsak, M,
Hu, WP,
Cui, XY,
Duka, T,
Takeda, Y,
Chia, W,
Sankar, N,
Ng, YK,
Ling, EA,
Maciag, T,
Small, D,
Trifonova, R,
Kopan, R,
Okano, H,
Nakafuku, M,
Chiba, S,
Hirai, H,
Aster, JC,
Schachner, M,
Pallen, CJ,
Watanabe, K,
Xiao, ZC
|
Cell |
2003 |
9819428 |
Delta-1 activation of notch-1 signaling results in HES-1 transactivation
Jarriault, S,
Le, Bail O,
Hirsinger, E,
Pourquie, O,
Logeat, F,
Strong, CF,
Brou, C,
Seidah, NG,
Isra, l A
|
Mol Cell Biol |
1998 |
9315665 |
Isolation and functional analysis of a cDNA for human Jagged2, a gene encoding a ligand for the Notch1 receptor
Luo, B,
Aster, JC,
Hasserjian, RP,
Kuo, F,
Sklar, J
|
Mol Cell Biol |
1997 |
18296446 |
Localization of the delta-like-1-binding site in human Notch-1 and its modulation by calcium affinity
Cordle, J,
Redfield, C,
Stacey, M,
van der Merwe, PA,
Willis, AC,
Champion, BR,
Hambleton, S,
Handford, PA
|
J Biol Chem |
2008 |
20418862 |
Cis-interactions between Notch and Delta generate mutually exclusive signalling states
Sprinzak, D,
Lakhanpal, A,
LeBon, L,
Santat, LA,
Fontes, ME,
Anderson, GA,
Garcia-Ojalvo, J,
Elowitz, MB
|
Nature |
2010 |
12050117 |
Mastermind mediates chromatin-specific transcription and turnover of the Notch enhancer complex
Fryer, CJ,
Lamar, E,
Turbachova, I,
Kintner, C,
Jones, KA
|
Genes Dev |
2002 |
8313469 |
Asymmetric distribution of numb protein during division of the sensory organ precursor cell confers distinct fates to daughter cells
Rhyu, MS,
Jan, LY,
Jan, YN
|
Cell |
1994 |
10713164 |
SKIP, a CBF1-associated protein, interacts with the ankyrin repeat domain of NotchIC To facilitate NotchIC function
Zhou, S,
Fujimuro, M,
Hsieh, JJ,
Chen, L,
Miyamoto, A,
Weinmaster, G,
Hayward, SD
|
Mol Cell Biol |
2000 |
18043734 |
An obligatory role of mind bomb-1 in notch signaling of mammalian development
Koo, BK,
Yoon, MJ,
Yoon, KJ,
Im, SK,
Kim, YY,
Kim, CH,
Suh, PG,
Jan, YN,
Kong, YY
|
PLoS One |
2007 |
18237417 |
The atypical mammalian ligand Delta-like homologue 1 (Dlk1) can regulate Notch signalling in Drosophila
Bray, SJ,
Takada, S,
Harrison, E,
Shen, SC,
Ferguson-Smith, AC
|
BMC Dev Biol |
2008 |