NOTCH1 associates with negative regulators NUMB and ITCH

Stable Identifier
R-HSA-1980128
Type
Reaction [binding]
Species
Homo sapiens
Compartment
cytosol, plasma membrane
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NOTCH1 associates with negative regulators NUMB and ITCH
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Genetic studies in Drosophila have identified Numb as an inhibitor of Notch signaling during development of the peripheral and central nervous systems as well as muscle cell differentiation. Both Drosophila and mammalian Numb are asymmetrically localized in dividing precursor cells, ensuring that cells adopt distinct cell fates through suppression of Notch signaling in one daughter cell (Rhyu et al. 1994). NUMB recruits E3 ubiquitin ligase ITCH (AIP4) to NOTCH1 and promotes sorting of NOTCH1 through late endosomes for degradation (McGill et al. 2009).

Literature References
PubMed ID Title Journal Year
19567869 Numb regulates post-endocytic trafficking and degradation of Notch1

McGill, MA, Dho, SE, Weinmaster, G, McGlade, CJ

J Biol Chem 2009
8313469 Asymmetric distribution of numb protein during division of the sensory organ precursor cell confers distinct fates to daughter cells

Rhyu, MS, Jan, LY, Jan, YN

Cell 1994
Participants
Input
Output
Participant Of
hasEvent
Inferred From
Numb recruits Itch to Notch1 (Mus musculus)
Authored
Egan, SE  (2011-11-14)
Orlic-Milacic, M  (2011-11-14)
Reviewed
Haw, R  (2012-02-06)
Created
Orlic-Milacic, M  (2011-11-09)