DLL4 binds NOTCH2

Stable Identifier
R-HSA-1980051
Type
Reaction [binding]
Species
Homo sapiens
Compartment
plasma membrane
ReviewStatus
5/5
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DLL4 binds NOTCH2
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DLL4, expressed on a neighboring cell, binds NOTCH2 receptor and activates NOTCH2 intracellular signaling. The study used recombinant NOTCH2 and DLL4, exogenously expressed in Chinese hamster ovary cells. The species origin of NOTCH2 and DLL4 is not specified in the manuscript by Ji et al. 2004. The impact of fringe-mediated modification of NOTCH2 on activation by DLL4 has not been examined.

Literature References
PubMed ID Title Journal Year
15569487 Function of Delta4 gene and its effects on 32D cell differentiation

Zhang, MH, Ji, CY, Zhao, JQ, Ma, DX, Cui, CS, Guo, NJ

Chin Med J (Engl) 2004
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as an event of
Orthologous Events
DLL4 binds NOTCH2 (Xenopus tropicalis)
Authored
Orlic-Milacic, M  (2013-01-11)
Reviewed
Ilagan, MXG  (2013-04-25)
Haw, R  (2013-01-14)
Boyle, S  (2013-04-25)
Created
Orlic-Milacic, M  (2011-11-09)
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