NOTCH1 stimulates HES1 transcription

Stable Identifier
R-HSA-1980047
Type
Reaction [BlackBoxEvent]
Species
Homo sapiens
Compartment
nucleoplasm
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NOTCH1 stimulates HES1 transcription
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NOTCH1 coactivator complex binds the promoter of HES1 gene and directly stimulates HES1 transcription. HES1 belongs to the bHLH family of transcription factors (Jarriault et al. 1995).

Literature References
PubMed ID Title Journal Year
7566092 Signalling downstream of activated mammalian Notch

Kopan, R, Schroeter, EH, Brou, C, Israel, A, Jarriault, S, Logeat, F

Nature 1995
Participants
Input
Output
Participates
as an event of
This event is regulated
Positively by
Regulator
NOTCH1 Coactivator Complex:HES1 Gene [nucleoplasm] (Homo sapiens)
Active Unit
NOTCH1 Coactivator Complex [nucleoplasm]
Inferred From
mNICD1 stimulates Hes1 transcription (Homo sapiens)
Authored
Orlic-Milacic, M  (2011-11-14)
Egan, SE  (2011-11-14)
Reviewed
Haw, R  (2012-02-06)
Ito, Y  (2017-01-31)
Chuang, LS  (2017-01-31)
Created
Orlic-Milacic, M  (2011-11-08)
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