NOTCH1 binds JAG2

Stable Identifier
R-HSA-1980044
Type
Reaction [binding]
Species
Homo sapiens
Compartment
plasma membrane
ReviewStatus
5/5
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NOTCH1 binds JAG2
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NOTCH1 is activated by JAG2 ligand expressed on a neighboring cell. When the mouse myoblast cell line C2C12 expressing exogenous human NOTCH1 is grown with NIH3T3 cells expressing exogenous human JAG2, myogenic differentiation is inhibited and a NOTCH1 polypeptide that corresponds to the NOTCH intracellular domain appears (Luo et al. 1997).
Literature References
PubMed ID Title Journal Year
11006133 Physical interaction of Delta1, Jagged1, and Jagged2 with Notch1 and Notch3 receptors

Shimizu, K, Hirai, H, Kumano, K, Saito, T, Chiba, S

Biochem Biophys Res Commun 2000
9315665 Isolation and functional analysis of a cDNA for human Jagged2, a gene encoding a ligand for the Notch1 receptor

Hasserjian, RP, Kuo, F, Aster, JC, Sklar, J, Luo, B

Mol Cell Biol 1997
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Orthologous Events
NOTCH1 binds JAG2 (Gallus gallus)
NOTCH1 binds JAG2 (Mus musculus)
Authored
Jassal, B  (2004-12-15)
Reviewed
Joutel, A  (2004-12-15)
Haw, R  (2012-02-06)
Created
Orlic-Milacic, M  (2011-11-09)
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