NOTCH1 binds JAG2

Stable Identifier
R-HSA-1980044
Type
Reaction
Species
Homo sapiens
Compartment
Locations in the PathwayBrowser
Summation

NOTCH1 is activated by JAG2 ligand expressed on a neighboring cell. When the mouse myoblast cell line C2C12 expressing exogenous human NOTCH1 is grown with NIH3T3 cells expressing exogenous human JAG2, myogenic differentiation is inhibited and a NOTCH1 polypeptide that corresponds to the NOTCH intracellular domain appears (Luo et al. 1997).

Literature References
PubMed ID Title Journal Year
9315665 Isolation and functional analysis of a cDNA for human Jagged2, a gene encoding a ligand for the Notch1 receptor

Luo, B, Aster, JC, Hasserjian, RP, Kuo, F, Sklar, J

Mol Cell Biol 1997
11006133 Physical interaction of Delta1, Jagged1, and Jagged2 with Notch1 and Notch3 receptors

Shimizu, K, Chiba, S, Saito, T, Kumano, K, Hirai, H

Biochem Biophys Res Commun 2000
Participants
Participant Of
Orthologous Events
Authored
Reviewed