NOTCH1 is activated by JAG2 ligand expressed on a neighboring cell. When the mouse myoblast cell line C2C12 expressing exogenous human NOTCH1 is grown with NIH3T3 cells expressing exogenous human JAG2, myogenic differentiation is inhibited and a NOTCH1 polypeptide that corresponds to the NOTCH intracellular domain appears (Luo et al. 1997).
Shimizu, K, Hirai, H, Kumano, K, Saito, T, Chiba, S
Hasserjian, RP, Kuo, F, Aster, JC, Sklar, J, Luo, B
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