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CDH1(155-882) [plasma membrane]
Stable Identifier
R-HSA-198003
Type
Protein [EntityWithAccessionedSequence]
Species
Homo sapiens
Compartment
plasma membrane
Synonyms
CDH1, Cadherin-1, Epithelial-cadherin, CAD1_HUMAN
Locations in the PathwayBrowser for interactor UniProt:Q96EF9 ZHX1R
Expand all
Developmental Biology (Homo sapiens)
Gastrulation (Homo sapiens)
Formation of definitive endoderm (Homo sapiens)
Expression of E-cadherin (CDH1) in definitive endoderm (Homo sapiens)
CDH1(155-882) [plasma membrane] (Homo sapiens)
MITF-M-regulated melanocyte development (Homo sapiens)
Transcriptional and post-translational regulation of MITF-M expression and activity (Homo sapiens)
SNAI2 and TBX3 repress CDH1 gene expression during melanocyte development (Homo sapiens)
CDH1(155-882) [plasma membrane] (Homo sapiens)
Extracellular matrix organization (Homo sapiens)
Integrin cell surface interactions (Homo sapiens)
Interaction of integrin alphaEbeta7 with Cadherin-1 (Homo sapiens)
CDH1(155-882) [plasma membrane] (Homo sapiens)
Immune System (Homo sapiens)
Adaptive Immune System (Homo sapiens)
Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell (Homo sapiens)
Epithelial cadherin binds to KLRG1 (Homo sapiens)
CDH1(155-882) [plasma membrane] (Homo sapiens)
Programmed Cell Death (Homo sapiens)
Apoptosis (Homo sapiens)
Apoptotic execution phase (Homo sapiens)
Apoptotic cleavage of cellular proteins (Homo sapiens)
Apoptotic cleavage of cell adhesion proteins (Homo sapiens)
Caspase-mediated cleavage of E-Cadherin (Homo sapiens)
CDH1(155-882) [plasma membrane] (Homo sapiens)
External Reference Information
External Reference
UniProt:P12830 CDH1
Gene Names
CDH1, CDHE, UVO
Chain
signal peptide:1-22, propeptide:23-154, chain:155-882, chain:701-882, chain:732-882, chain:751-882
Reference Genes
BioGPS Gene:999 CDH1
COSMIC (genes):CDH1 CDH1
CTD Gene:999 CDH1
dbSNP Gene:999 CDH1
ENSEMBL:ENSG00000039068 CDH1
ENSEMBL_homo_sapiens_GENE:ENSG00000039068.20 CDH1
HGNC:1748 CDH1
KEGG Gene (Homo sapiens):999 CDH1
Monarch:999 CDH1
NCBI Gene:999 CDH1
OMIM:192090 CDH1
UCSC:P12830 CDH1
Reference Transcript
RefSeq:NM_001317185.1 CDH1
RefSeq:NM_001317186.1 CDH1
RefSeq:NM_004360.4 CDH1
RefSeq:NM_001317184.1 CDH1
Other Identifiers
11716905_a_at
11716906_a_at
16820486
201130_PM_s_at
201130_s_at
201131_PM_s_at
201131_s_at
2082_s_at
3666410
3666411
3666412
3666427
3666430
3666431
3666432
3666433
3666435
3666437
3666438
3666442
3666444
3666445
3666450
3666451
3666452
3666453
3666454
3666455
3666459
7996837
977_s_at
999
A_23_P206359
GE57732
GO:0000902
GO:0005509
GO:0005515
GO:0005576
GO:0005615
GO:0005768
GO:0005794
GO:0005802
GO:0005856
GO:0005886
GO:0005912
GO:0006351
GO:0006355
GO:0006886
GO:0006913
GO:0007043
GO:0007155
GO:0007156
GO:0007416
GO:0008013
GO:0008092
GO:0009410
GO:0009636
GO:0009898
GO:0010033
GO:0010468
GO:0015629
GO:0016020
GO:0016328
GO:0016339
GO:0016342
GO:0016600
GO:0021983
GO:0022408
GO:0023052
GO:0030027
GO:0030054
GO:0030154
GO:0030163
GO:0030336
GO:0030506
GO:0030517
GO:0030864
GO:0031175
GO:0031410
GO:0032794
GO:0034330
GO:0034332
GO:0042307
GO:0042802
GO:0043226
GO:0043296
GO:0044331
GO:0045295
GO:0045296
GO:0045893
GO:0046872
GO:0048471
GO:0048856
GO:0048870
GO:0050839
GO:0070062
GO:0070161
GO:0071285
GO:0071681
GO:0072659
GO:0098609
GO:0098794
GO:0098978
GO:0099576
GO:0140459
GO:1990782
HMNXSV003039550
ILMN_1770940
PH_hs_0011491
TC16000559.hg
Z35402_rna1_s_at
g340184_3p_a_at
g4757959_3p_a_at
Participates
as a component of
E-cadherin bound to KLRG1 [plasma membrane] (Homo sapiens)
CDH1(155-882):Ca2+ dimer [plasma membrane] (Homo sapiens)
Integrin alphaEbeta7:Cadherin-1 [plasma membrane] (Homo sapiens)
as an input of
Epithelial cadherin binds to KLRG1 (Homo sapiens)
Interaction of integrin alphaEbeta7 with Cadherin-1 (Homo sapiens)
Caspase-mediated cleavage of E-Cadherin (Homo sapiens)
as an output of
SNAI2 and TBX3 repress CDH1 gene expression during melanocyte development (Homo sapiens)
Expression of E-cadherin (CDH1) in definitive endoderm (Homo sapiens)
as a member of
Classic Cadherin [plasma membrane] (Homo sapiens)
Other forms of this molecule
CDH1(732-882) [plasma membrane]
CDH1(155-700) [plasma membrane]
CDH1(701-882) [extracellular region]
Ub-K,p-Y753,Y754-CDH1(155-882) [plasma membrane]
p-Y753,Y754-CDH1(155-882) [plasma membrane]
CDH1(155-750) [plasma membrane]
CDH1(751-882) [plasma membrane]
Inferred To
CDH1 [plasma membrane]
(Bos taurus)
CDH1 [plasma membrane]
(Canis familiaris)
CDH1 [plasma membrane]
(Sus scrofa)
CDH1(155-882) [plasma membrane]
(Canis familiaris)
CDH1(155-882) [plasma membrane]
(Danio rerio)
CDH1(155-882) [plasma membrane]
(Gallus gallus)
CDH1(155-882) [plasma membrane]
(Mus musculus)
CDH1(155-882) [plasma membrane]
(Rattus norvegicus)
Homologues of CDH1(155-882) [plasma membrane]
(Canis familiaris)
CadN2 [plasma membrane]
(Drosophila melanogaster)
Cross References
RefSeq
NP_001304113.1
,
NP_004351.1
,
NP_001304115.1
,
NP_001304114.1
OpenTargets
ENSG00000039068
HPA
ENSG00000039068-CDH1
GeneCards
P12830
Ensembl
ENSP00000414946
,
ENST00000422392
,
ENSP00000261769
,
ENSG00000039068
,
ENST00000261769
PRO
P12830
Pharos - Targets
P12830
Orphanet
15419
HMDB Protein
HMDBP02891
PDB
2OMZ
,
6OLF
,
2OMT
,
7STZ
,
6VEL
,
2OMU
,
3L6X
,
3FF7
,
3L6Y
,
1O6S
,
3FF8
,
2OMV
,
6OLG
,
4ZTE
,
2OMX
,
8H62
,
2O72
,
6CXY
,
4ZT1
,
6OLE
,
2OMY
Interactors (51)
Accession
#Entities
Entities
Confidence Score
Evidence (IntAct)
UniProt:P35222 CTNNB1
20
CTNNB1 S45A [cytosol]
(R-HSA-9663982)
CTNNB1 S45F [cytosol]
(R-HSA-4791268)
CTNNB1 S45C [cytosol]
(R-HSA-9663983)
CTNNB1 S45Y [cytosol]
(R-HSA-9663975)
CTNNB1 S45N [cytosol]
(R-HSA-9663984)
CTNNB1 S45P [cytosol]
(R-HSA-4791272)
pT41,S45-CTNNB1 S37P [cytosol]
(R-HSA-9663981)
pT41,S45-CTNNB1 S37F [cytosol]
(R-HSA-4839621)
pT41,S45-CTNNB1 S37A [cytosol]
(R-HSA-4839619)
pT41,S45-CTNNB1 S37Y [cytosol]
(R-HSA-9663978)
pT41,S45-CTNNB1 S37C [cytosol]
(R-HSA-4839617)
pS37,T41,S45-CTNNB1 S33A [cytosol]
(R-HSA-9663976)
pS37,T41,S45-CTNNB1 S33T [cytosol]
(R-HSA-9663977)
pS37,T41,S45-CTNNB1 S33C [cytosol]
(R-HSA-4839630)
pS37,T41,S45-CTNNB1 S33F [cytosol]
(R-HSA-4839628)
pS37,T41,S45-CTNNB1 S33P [cytosol]
(R-HSA-4839626)
pS37,T41,S45-CTNNB1 S33Y [cytosol]
(R-HSA-4839625)
pS45-CTNNB1 T41N [cytosol]
(R-HSA-9663980)
pS45-CTNNB1 T41A [cytosol]
(R-HSA-4836868)
pS45-CTNNB1 T41I [cytosol]
(R-HSA-4839612)
0.962
23
UniProt:P12830 CDH1
8
CDH1(732-882) [plasma membrane]
(R-HSA-3827997)
CDH1(155-700) [plasma membrane]
(R-HSA-2534244)
CDH1(701-882) [extracellular region]
(R-HSA-2534158)
Ub-K,p-Y753,Y754-CDH1(155-882) [plasma membrane]
(R-HSA-8877002)
p-Y753,Y754-CDH1(155-882) [plasma membrane]
(R-HSA-8876938)
CDH1(155-750) [plasma membrane]
(R-HSA-202940)
CDH1(751-882) [plasma membrane]
(R-HSA-202929)
CDH1(155-882) [plasma membrane]
(R-HSA-198003)
0.875
7
UniProt:P35221 CTNNA1
2
CTNNA1 [cytosol]
(R-HSA-191697)
CTNNA1 [plasma membrane]
(R-HSA-191735)
0.803
8
UniProt:P00533 EGFR
20
p-6Y-EGFR [clathrin-coated endocytic vesicle membrane]
(R-HSA-8869138)
p-5Y-EGFRvIII [plasma membrane]
(R-HSA-1248649)
EGFRvIII [plasma membrane]
(R-HSA-1214162)
p-6Y-EGFR E746_A750del;T790M [plasma membrane]
(R-HSA-1182985)
p-6Y-EGFR L858R;T790M [plasma membrane]
(R-HSA-1182984)
p-6Y-EGFR A767_V769dup [plasma membrane]
(R-HSA-1996343)
p-6Y-EGFR N771_H773dup [plasma membrane]
(R-HSA-1996342)
p-6Y-EGFR K739_I744dup [plasma membrane]
(R-HSA-1996346)
p-6Y-EGFR D770_N771insNPG [plasma membrane]
(R-HSA-1996335)
p-6Y-EGFR E746_A750del [plasma membrane]
(R-HSA-1181214)
p-6Y-EGFR L858R [plasma membrane]
(R-HSA-1173211)
p-6Y-EGFR G719S [plasma membrane]
(R-HSA-1169417)
p-6Y-EGFR L747_P753delinsS [plasma membrane]
(R-HSA-1228038)
p-6Y-EGFR L747_A750delinsP [plasma membrane]
(R-HSA-1228044)
p-6Y-EGFR L747_T751del [plasma membrane]
(R-HSA-1228041)
p-6Y-EGFR L747_S752del [plasma membrane]
(R-HSA-1228040)
p-6Y-EGFR L747_T751delinsP [plasma membrane]
(R-HSA-1228042)
p-6Y-EGFR E746_T751delinsA [plasma membrane]
(R-HSA-1228037)
p-6Y-EGFR E746_S752delinsV [plasma membrane]
(R-HSA-1228039)
p-6Y-EGFR L861Q [plasma membrane]
(R-HSA-1177541)
0.735
4
UniProt:O60716 CTNND1
1
CTNND1 [plasma membrane]
(R-HSA-418996)
0.731
9
UniProt:Q6IQ23 PKHA7
0.695
5
UniProt:P0DJM0 inlA
1
InlA [peptidoglycan-based cell wall]
(R-LMO-8876505)
0.683
3
UniProt:Q9JIY2
1
Cbll1 [cytosol]
(R-MMU-8851646)
0.645
21
UniProt:P30260 CDC27
2
CDC27 [nucleoplasm]
(R-HSA-174175)
CDC27 [cytosol]
(R-HSA-174073)
0.589
2
UniProt:Q15139 PRKD1
1
PRKD1 [cytosol]
(R-HSA-58210)
0.571
7
UniProt:P49768 PSEN1
6
PSEN1(1-467) [plasma membrane]
(R-HSA-201606)
PSEN1(299-467) [azurophil granule membrane]
(R-HSA-6799234)
PSEN1(1-467) [azurophil granule membrane]
(R-HSA-6799235)
PSEN1(1-298) [azurophil granule membrane]
(R-HSA-6799209)
PSEN1(1-298) [plasma membrane]
(R-HSA-2534298)
PSEN1(299-467) [plasma membrane]
(R-HSA-2534245)
0.564
2
UniProt:Q96EF9 ZHX1R
0.556
3
UniProt:P17612 PRKACA
4
PRKACA [mitochondrial matrix]
(R-HSA-9838291)
PRKACA [ciliary base]
(R-HSA-5610402)
PRKACA [nucleoplasm]
(R-HSA-111936)
PRKACA [cytosol]
(R-HSA-57844)
0.556
3
UniProt:O94983-5 CAMTA2
0.556
3
UniProt:Q9HC98-4 NEK6
0.556
3
UniProt:Q02978 SLC25A11
1
SLC25A11 [mitochondrial inner membrane]
(R-HSA-198451)
0.556
3
UniProt:P49184 DNASE1L1
2
DNASE1L1 [extracellular region]
(R-HSA-6806320)
DNASE1L1 [specific granule lumen]
(R-HSA-6799554)
0.556
3
UniProt:Q9BT49 THAP7
0.556
3
UniProt:Q9Y617 PSAT1
1
PXLP-K200-PSAT1 [cytosol]
(R-HSA-977330)
0.556
3
UniProt:Q9BQ29 Q9BQ29
0.556
3
UniProt:Q8TB02 Q8TB02
0.556
3
UniProt:P43356 MAGA2
0.556
3
UniProt:Q8N2W9 PIAS4
2
PIAS4 [nucleoplasm]
(R-HSA-2993789)
monoSUMO1-K35-PIAS4 [nucleoplasm]
(R-HSA-3968415)
0.556
3
UniProt:Q9ULW0 TPX2
2
TPX2 [cytosol]
(R-HSA-8853407)
TPX2 [nucleoplasm]
(R-HSA-2564700)
0.556
3
UniProt:Q7Z434 MAVS
2
MAVS [mitochondrial outer membrane]
(R-HSA-913730)
K48polyUb-MAVS [mitochondrial outer membrane]
(R-HSA-983463)
0.556
3
UniProt:P16422 EPCAM
1
EPCAM [plasma membrane]
(R-HSA-375068)
0.556
3
UniProt:Q8NBT0 POC1A
0.556
3
UniProt:P48775 TDO2
1
TDO2 [cytosol]
(R-HSA-71184)
0.556
3
UniProt:P50454 SERPINH1
1
SERPINH1 [endoplasmic reticulum lumen]
(R-HSA-2127480)
0.556
3
UniProt:Q96QH2 PRAM
0.556
3
UniProt:P37173 TGFBR2
9
TGFBR2 Y470D [plasma membrane]
(R-HSA-3640905)
TGFBR2 E526Q [plasma membrane]
(R-HSA-3645770)
TGFBR2 D522N [plasma membrane]
(R-HSA-3640907)
TGFBR2 R528H [plasma membrane]
(R-HSA-3640894)
TGFBR2 R528C [plasma membrane]
(R-HSA-3640899)
TGFBR2 K128Afs*3 [cytosol]
(R-HSA-3642173)
TGFBR2 K128Sfs*35 [cytosol]
(R-HSA-3642166)
NEDD8-K556,K567-TGFBR2 [plasma membrane]
(R-HSA-4332222)
TGFBR2 [plasma membrane]
(R-HSA-170842)
0.556
3
UniProt:Q8NCR3 MFI
0.556
3
IntAct:EBI-25833683 CCSB
0.556
3
UniProt:Q9NPC7 MYNN
0.556
3
UniProt:Q8N323 NXPE1
0.556
3
UniProt:Q6UXH1-2 CRELD2
0.556
3
UniProt:Q7Z6Z7-2 HUWE1
0.556
3
UniProt:P11362 FGFR1
9
FGFR1(22-763):TACC1(571-805) fusion [plasma membrane]
(R-HSA-8853241)
FGFR1 K656E [plasma membrane]
(R-HSA-1614373)
FGFR1 N546K [plasma membrane]
(R-HSA-1614377)
FGFR1 R576W [plasma membrane]
(R-HSA-2011844)
p-6Y-FGFR1(22-763):TACC1(571-805) fusion [plasma membrane]
(R-HSA-8853142)
p-8Y-FGFR1 K656E [plasma membrane]
(R-HSA-2023356)
p-8Y-FGFR1 N546K [plasma membrane]
(R-HSA-2023358)
p-8Y- FGFR1 R576W [plasma membrane]
(R-HSA-2023361)
FGFR1 [plasma membrane]
(R-HSA-9756433)
0.536
3
UniProt:P13569 CFTR
17
PolyUb-CFTR [clathrin-coated endocytic vesicle membrane]
(R-HSA-8869104)
PolyUb-CFTR [plasma membrane]
(R-HSA-8867595)
CFTR [lysosomal membrane]
(R-HSA-5627279)
CFTR [Golgi-associated vesicle membrane]
(R-HSA-5627079)
CFTR [endosome membrane]
(R-HSA-6782965)
PolyUb-CFTR [endosome membrane]
(R-HSA-6782976)
CFTR F508del [endoplasmic reticulum membrane]
(R-HSA-8866834)
ub-CFTR F508del [cytosol]
(R-HSA-8866838)
ub-CFTR F508del [endoplasmic reticulum membrane]
(R-HSA-8866842)
CFTR G542* [plasma membrane]
(R-HSA-5678986)
CFTR G551D [plasma membrane]
(R-HSA-5678977)
CFTR W1282* [plasma membrane]
(R-HSA-5678976)
CFTR F508del [plasma membrane]
(R-HSA-5678978)
CFTR N1303K [plasma membrane]
(R-HSA-5678983)
CFTR [plasma membrane]
(R-HSA-383188)
CFTR [endoplasmic reticulum membrane]
(R-HSA-8866837)
misfolded CFTR [endoplasmic reticulum membrane]
(R-HSA-8868730)
0.527
8
UniProt:Q9UN70 PCDGK
0.527
2
UniProt:Q9UI47 CTNA3
0.527
3
UniProt:P33724
5
CAV1 [endocytic vesicle membrane]
(R-CFA-535009)
CAV1 [lipid droplet]
(R-CFA-163510)
CAV1 [early endosome membrane]
(R-CFA-5368451)
CAV1 [plasma membrane]
(R-CFA-534994)
CAV1 [Golgi membrane]
(R-CFA-204504)
0.525
2
UniProt:P02511 CRYAB
1
CRYAB [nucleoplasm]
(R-HSA-6806336)
0.524
2
UniProt:cagA A0A2X5ABY1
0.524
2
UniProt:P62136 PPP1CA
1
PPP1CA [cytosol]
(R-HSA-163525)
0.524
2
UniProt:O43707 ACTN4
3
ACTN4 [cytosol]
(R-HSA-390558)
ACTN4 [platelet alpha granule lumen]
(R-HSA-198240)
ACTN4 [extracellular region]
(R-HSA-349729)
0.499
2
UniProt:Q68CZ2 TNS3
1
TNS3 [cytosol]
(R-HSA-8875524)
0.499
2
UniProt:Q9H8V3 ECT2
1
ECT2 [cytosol]
(R-HSA-195036)
0.499
3
UniProt:P07900 HSP90AA1
8
HSP90AA1 [secretory granule lumen]
(R-HSA-6801515)
HSP90AA1 [ficolin-1-rich granule lumen]
(R-HSA-6801470)
HSP90AA1 [plasma membrane]
(R-HSA-534996)
HSP90AA1 [endocytic vesicle lumen]
(R-HSA-3221912)
HSP90AA1 [extracellular region]
(R-HSA-3221946)
HSP90AA1 [nucleoplasm]
(R-HSA-5082401)
HSP90AA1 [cytosol]
(R-HSA-192864)
HSP90AA1 [lysosomal lumen]
(R-HSA-9622850)
0.499
2
UniProt:P12931 SRC
6
p-Y419-SRC [nucleoplasm]
(R-HSA-8937690)
SRC [cytosol]
(R-HSA-9628701)
p-Y419-SRC [cytosol]
(R-HSA-8964276)
MyrG-SRC [plasma membrane]
(R-HSA-8876922)
MyrG,p-Y530-SRC [plasma membrane]
(R-HSA-377598)
MyrG-p-Y419-SRC [plasma membrane]
(R-HSA-1810408)
0.499
2
UniProt:A0A0S2C3P2 A0A0S2C3P2
0.463
3
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