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DHFR [cytosol]
Stable Identifier
R-HSA-197984
Type
Protein [EntityWithAccessionedSequence]
Species
Homo sapiens
Compartment
cytosol
Synonyms
Dihydrofolate reductase, DYR_HUMAN
Locations in the PathwayBrowser
Expand all
Cell Cycle (Homo sapiens)
Cell Cycle, Mitotic (Homo sapiens)
Mitotic G1 phase and G1/S transition (Homo sapiens)
G1/S Transition (Homo sapiens)
G1/S-Specific Transcription (Homo sapiens)
DHFR gene expression is stimulated by E2F1 (Homo sapiens)
DHFR [cytosol] (Homo sapiens)
Metabolism (Homo sapiens)
Metabolism of vitamins and cofactors (Homo sapiens)
Metabolism of cofactors (Homo sapiens)
Tetrahydrobiopterin (BH4) synthesis, recycling, salvage and regulation (Homo sapiens)
Salvage - BH2 is reduced to BH4 by DHFR (Homo sapiens)
DHFR dimer [cytosol] (Homo sapiens)
DHFR [cytosol] (Homo sapiens)
Metabolism of water-soluble vitamins and cofactors (Homo sapiens)
Metabolism of folate and pterines (Homo sapiens)
DHFR dimer binds DHFR inhibitors (Homo sapiens)
DHFR dimer [cytosol] (Homo sapiens)
DHFR [cytosol] (Homo sapiens)
DHFR dimer:DHFR inhibitors [cytosol] (Homo sapiens)
DHFR dimer [cytosol] (Homo sapiens)
DHFR [cytosol] (Homo sapiens)
DHFR dimer reduces FOLA to DHF (Homo sapiens)
DHFR dimer [cytosol] (Homo sapiens)
DHFR [cytosol] (Homo sapiens)
External Reference Information
External Reference
UniProt:P00374 DHFR
Gene Names
DHFR, Dihydrofolate reductase
Chain
chain:1-187
Reference Genes
BioGPS Gene:1719 DHFR
COSMIC (genes):DHFR DHFR
CTD Gene:1719 DHFR
dbSNP Gene:1719 DHFR
ENSEMBL:ENSG00000228716 DHFR
HGNC:2861 DHFR
KEGG:hsa:1719 DHFR
Monarch:1719 DHFR
NCBI Gene:1719 DHFR
OMIM:126060 DHFR
UCSC:P00374 DHFR
Reference Transcript
RefSeq:NM_000791.3 DHFR
RefSeq:NM_001290354.1 DHFR
Other Identifiers
11718998_x_at
11718999_x_at
11719000_x_at
11747279_x_at
11747280_x_at
11749867_x_at
1178_at
1610_s_at
16997662
1719
202532_3p_s_at
202532_PM_s_at
202532_s_at
202533_PM_s_at
202533_s_at
202534_3p_x_at
202534_PM_x_at
202534_x_at
2490860
2864624
2864625
2864626
2864627
2864628
2864629
2864630
2864631
2864634
2864635
2864636
2864637
2864638
2864648
2948972
37913_at
3802221
3802223
4878663C_3p_s_at
48808_3p_at
48808_PM_at
48808_at
64237_r_at
8022640
8043036
8112902
A_23_P167553
A_24_P320284
A_24_P343095
A_24_P942328
A_32_P211045
GE79107
GO:0000900
GO:0003723
GO:0003729
GO:0003824
GO:0004146
GO:0005515
GO:0005542
GO:0005737
GO:0005739
GO:0005829
GO:0006575
GO:0006729
GO:0006730
GO:0006766
GO:0016491
GO:0017148
GO:0031103
GO:0031427
GO:0043226
GO:0045182
GO:0046452
GO:0046653
GO:0046654
GO:0046655
GO:0048856
GO:0050661
GO:0051000
GO:0070402
GO:1990825
GO:2000121
HMNXSV003000745
ILMN_1665821
ILMN_1778543
ILMN_1782813
J00139_s_at
PH_hs_0041095
TC05001538.hg
g12652874_3p_a_at
g12652874_3p_s_at
g12652874_3p_x_at
g13097773_3p_a_at
g7262376_3p_s_at
g8924154_3p_s_at
Participates
as an output of
DHFR gene expression is stimulated by E2F1 (Homo sapiens)
as a component of
DHFR dimer [cytosol] (Homo sapiens)
Inferred To
dhfr [cytosol]
(Danio rerio)
DHFR2 [cytosol]
(Caenorhabditis elegans)
DHFR2 [cytosol]
(Dictyostelium discoideum)
DHFR2 [cytosol]
(Drosophila melanogaster)
DHFR2 [cytosol]
(Mus musculus)
DHFR2 [cytosol]
(Rattus norvegicus)
DHFR2 [cytosol]
(Saccharomyces cerevisiae)
DHFR2 [cytosol]
(Schizosaccharomyces pombe)
DHFR [cytosol]
(Bos taurus)
DHFR [cytosol]
(Canis familiaris)
DHFR [cytosol]
(Gallus gallus)
DHFR [cytosol]
(Sus scrofa)
Cross References
Guide to Pharmacology - Targets
2603
OpenTargets
ENSG00000228716
ENSEMBL
ENSG00000228716
,
ENSP00000396308
,
ENST00000504396
,
ENST00000505337
,
ENSP00000426474
,
ENST00000439211
,
ENSP00000421334
ZINC - FDA approved
DYR_HUMAN
ZINC - Substances
DYR_HUMAN
ZINC - Biogenic
DYR_HUMAN
ZINC target
P00374
PRO
P00374
PDB
3S7A
,
5HT4
,
5HPB
,
4KD7
,
3NTZ
,
3N0H
,
3F91
,
2W3M
,
8WGN
,
3GHC
,
6DE4
,
3GI2
,
3FS6
,
4DDR
,
5HVE
,
5SD7
,
2W3A
,
4KFJ
,
5SD8
,
5SDA
,
3EIG
,
3NXT
,
4M6K
,
3S3V
,
3NXR
,
3NXX
,
5HUI
,
4KAK
,
3NXV
,
1YHO
,
5HQY
,
5HQZ
,
1MVS
,
1MVT
,
1BOZ
,
5HVB
,
1OHK
,
1HFR
,
2DHF
,
1S3U
,
1DHF
,
1S3V
,
2C2S
,
1PD8
,
1KMS
,
6A7E
,
4QHV
,
3NZD
,
7ESE
,
4KEB
,
5HSR
,
1U71
,
1U72
,
5HSU
,
4G95
,
5HT5
,
6A7C
,
4KBN
,
6VCJ
,
2W3B
,
7XI7
,
5SD6
,
4M6J
,
5SD9
,
6DAV
,
3NU0
,
4M6L
,
3GHW
,
5SDB
,
3NXY
,
3GHV
,
3NXO
,
3GYF
,
3L3R
,
1DRF
,
1PDB
,
1DLR
,
3OAF
,
4QJC
,
1DLS
,
3F8Z
,
3F8Y
,
1OHJ
,
1HFP
,
1HFQ
,
2C2T
,
1S3W
,
1PD9
,
1KMV
ZINC - Investigational
DYR_HUMAN
ZINC - Metabolites
DYR_HUMAN
HPA
ENSG00000228716-DHFR
GeneCards
DHFR
Pharos - Targets
P00374
Orphanet
DHFR
ZINC - Predictions - Purchasable
DYR_HUMAN
HMDB Protein
HMDBP00790
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