Reactome | PTPN6 [cytosol]

PTPN6 [cytosol]

Stable Identifier

R-HSA-197938

Type

Protein [EntityWithAccessionedSequence]

Species

Homo sapiens

Compartment

cytosol

Synonyms

SHP1, SHP-1, Src homology phosphatase-1, Protein-tyrosine phosphatase, non-receptor type 6, PTN6_HUMAN

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Locations in the PathwayBrowser for interactor UniProt:P32927 CSF2RB

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Disease (Homo sapiens)

- Diseases of signal transduction by growth factor receptors and second messengers (Homo sapiens)
  - Signaling by ALK in cancer (Homo sapiens)
    - Signaling by ALK fusions and activated point mutants (Homo sapiens)
      - Nuclear events stimulated by ALK signaling in cancer (Homo sapiens)
        
        DNMT1-dependent PTPN6 gene silencing (Homo sapiens)
        
        PTPN6 [cytosol] (Homo sapiens)

External Reference Information

External Reference

UniProt:P29350 PTPN6

Gene Names

PTPN6, HCP, PTP1C

Chain

chain:1-595

Reference Genes

BioGPS Gene:5777 PTPN6

COSMIC (genes):PTPN6 PTPN6

CTD Gene:5777 PTPN6

dbSNP Gene:5777 PTPN6

ENSEMBL:ENSG00000111679 PTPN6

ENSEMBL_homo_sapiens_GENE:ENSG00000111679.17 PTPN6

HGNC:9658 PTPN6

KEGG Gene (Homo sapiens):5777 PTPN6

Monarch:5777 PTPN6

NCBI Gene:5777 PTPN6

OMIM:176883 PTPN6

UCSC:P29350 PTPN6

Reference Transcript

Other Identifiers

11726034_a_at

11739054_a_at

11739055_x_at

16747623

206687_PM_s_at

206687_s_at

3403093

3403095

3403096

3403097

3403099

3403102

3403106

3403107

3403108

3403109

3403110

3403111

3403113

3403114

3403117

3403118

3403119

3403120

3403121

3403122

3403123

5777

794_at

7953569

A_23_P162486

GE59877

GO:0000165

GO:0000278

GO:0001784

GO:0002244

GO:0002376

GO:0002924

GO:0003824

GO:0004721

GO:0004725

GO:0004726

GO:0005001

GO:0005515

GO:0005576

GO:0005615

GO:0005634

GO:0005654

GO:0005730

GO:0005737

GO:0005829

GO:0005886

GO:0005911

GO:0006470

GO:0006954

GO:0007155

GO:0007186

GO:0008284

GO:0008285

GO:0012501

GO:0016020

GO:0016311

GO:0016787

GO:0016791

GO:0017124

GO:0018108

GO:0019221

GO:0019901

GO:0023052

GO:0030154

GO:0030220

GO:0031295

GO:0031410

GO:0032715

GO:0032720

GO:0032991

GO:0033007

GO:0033630

GO:0035335

GO:0035556

GO:0035580

GO:0035855

GO:0036211

GO:0042060

GO:0042098

GO:0042105

GO:0042130

GO:0042169

GO:0042267

GO:0042981

GO:0043226

GO:0043409

GO:0045577

GO:0048856

GO:0050732

GO:0050839

GO:0050852

GO:0050853

GO:0050860

GO:0051279

GO:0051897

GO:0055065

GO:0055085

GO:0060089

GO:0060338

GO:0070062

GO:0070372

GO:0070527

GO:0071310

GO:0098542

GO:0106015

GO:0140031

GO:0140096

GO:1904724

GO:1905867

GO:2000045

HMNXSV003044817

ILMN_1664122

ILMN_1716578

ILMN_1738675

PH_hs_0003980

TC12000101.hg

X62055_at

g4506296_3p_a_at

Participates

as a component of

as an input of

as an output of

DNMT1-dependent PTPN6 gene silencing (Homo sapiens)

as a member of

This entity regulates

Negatively

Transphosphorylation of JAK1 (Homo sapiens)

Other forms of this molecule

PTPN6 [specific granule lumen]

PTPN6 [extracellular region]

PTPN6 [tertiary granule lumen]

PTPN6 [nucleoplasm]

Inferred To

ptp-2 [cytosol] (Caenorhabditis elegans)

PTPN6 [cytosol] (Bos taurus)

PTPN6 [cytosol] (Canis familiaris)

PTPN6 [cytosol] (Drosophila melanogaster)

PTPN6 [cytosol] (Gallus gallus)

PTPN6 [cytosol] (Mus musculus)

PTPN6 [cytosol] (Rattus norvegicus)

PTPN6 [cytosol] (Sus scrofa)

Cross References

RefSeq

NP_002822.2, NP_536858.1, XP_011519290.1, NP_536859.1

OpenTargets

ENSG00000111679

ZINC - Substances

PTN6_HUMAN

ZINC target

P29350

ZINC - Biogenic

PTN6_HUMAN

PRO

P29350

PDB

6SM5, 4GRZ, 2YU7, 8YHI, 4GRY, 4GS0, 4HJQ, 1FPR, 3PS5, 2RMX, 1X6C, 1GWZ, 4HJP, 2B3O

IntEnz

3.1.3.48

GeneCards

P29350

HPA

ENSG00000111679-PTPN6

Ensembl

ENST00000399448, ENST00000456013, ENSP00000391592, ENST00000318974, ENSG00000111679, ENSP00000326010, ENSP00000382376

Pharos - Targets

P29350

ZINC - Predictions - Purchasable

PTN6_HUMAN

HMDB Protein

HMDBP02499

Interactors (29)

Accession	#Entities	Entities	Confidence Score	Evidence (IntAct)
UniProt:P43628 KIR2DL3	1	KIR2DL3 [plasma membrane] (R-HSA-3006532)	0.824	13
UniProt:P20138 CD33	3	CD33 [tertiary granule membrane] (R-HSA-6800959) CD33 [plasma membrane] (R-HSA-197719) CD33 [specific granule membrane] (R-HSA-6799615)	0.824	10
UniProt:P19235 EPOR	2	EPOR [plasma membrane] (R-HSA-1168347) p-8Y-EPOR [plasma membrane] (R-HSA-9006274)	0.8	11
UniProt:P31994 FCGR2B	1	FCGR2B [plasma membrane] (R-HSA-197854)	0.669	3
UniProt:P62993 GRB2	1	GRB2 [cytosol] (R-HSA-8983328)	0.646	3
UniProt:P08922 ROS1			0.642	4
UniProt:P06239 LCK	4	p-Y394-LCK [plasma membrane] (R-HSA-8857940) p-Y505-LCK [plasma membrane] (R-HSA-202159) p-Y394-LCK [cytosol] (R-HSA-202308) LCK [cytosol] (R-HSA-167609)	0.623	5
UniProt:Q6GTX8 LAIR1	3	LAIR1 [specific granule membrane] (R-HSA-6799644) LAIR1 [plasma membrane] (R-HSA-5686426) LAIR1 [tertiary granule membrane] (R-HSA-6800947)	0.613	5
UniProt:O94916-1 NFAT5			0.602	4
UniProt:Q9UKJ1 PILRA	1	PILRA [plasma membrane] (R-HSA-3008978)	0.581	5
UniProt:P35968 KDR	5	p-11Y-VEGFR2(20-662)insVAGTWTSGLMSL-PDGFRA(471-1089) [plasma membrane] (R-HSA-9673636) VEGFR2(20-662)insVAGTWTSGLMSL-PDGFRA(471-1089) fusion [plasma membrane] (R-HSA-9673613) p-Y801,Y1054,Y1175-KDR [plasma membrane] (R-HSA-9860484) VEGFR2 [plasma membrane] (R-HSA-195382) p-6Y-VEGFR2 [plasma membrane] (R-HSA-4420103)	0.573	2
UniProt:B7UM99 TIR			0.571	4
UniProt:Q05209 PTPN12	2	PTPN12 [cytosol] (R-HSA-432933) PTPN12 [nucleoplasm] (R-HSA-9008905)	0.564	3
UniProt:Q9BZW8 CD244	1	CD244 [plasma membrane] (R-HSA-197846)	0.564	2
UniProt:Q13643 FHL3			0.556	3
UniProt:P00533 EGFR	20	p-6Y-EGFR [clathrin-coated endocytic vesicle membrane] (R-HSA-8869138) p-5Y-EGFRvIII [plasma membrane] (R-HSA-1248649) EGFRvIII [plasma membrane] (R-HSA-1214162) p-6Y-EGFR E746_A750del;T790M [plasma membrane] (R-HSA-1182985) p-6Y-EGFR L858R;T790M [plasma membrane] (R-HSA-1182984) p-6Y-EGFR A767_V769dup [plasma membrane] (R-HSA-1996343) p-6Y-EGFR N771_H773dup [plasma membrane] (R-HSA-1996342) p-6Y-EGFR K739_I744dup [plasma membrane] (R-HSA-1996346) p-6Y-EGFR D770_N771insNPG [plasma membrane] (R-HSA-1996335) p-6Y-EGFR E746_A750del [plasma membrane] (R-HSA-1181214) p-6Y-EGFR L858R [plasma membrane] (R-HSA-1173211) p-6Y-EGFR G719S [plasma membrane] (R-HSA-1169417) p-6Y-EGFR L747_P753delinsS [plasma membrane] (R-HSA-1228038) p-6Y-EGFR L747_A750delinsP [plasma membrane] (R-HSA-1228044) p-6Y-EGFR L747_T751del [plasma membrane] (R-HSA-1228041) p-6Y-EGFR L747_S752del [plasma membrane] (R-HSA-1228040) p-6Y-EGFR L747_T751delinsP [plasma membrane] (R-HSA-1228042) p-6Y-EGFR E746_T751delinsA [plasma membrane] (R-HSA-1228037) p-6Y-EGFR E746_S752delinsV [plasma membrane] (R-HSA-1228039) p-6Y-EGFR L861Q [plasma membrane] (R-HSA-1177541)	0.547	2
UniProt:P24394 IL4R	2	IL4R [plasma membrane] (R-HSA-449670) p-Y-IL4R [plasma membrane] (R-HSA-6786087)	0.527	2
UniProt:Q14790 CASP8	8	CASP8(1-374) [cytosol] (R-HSA-3465404) CASP8(217-374) [mitochondrial outer membrane] (R-HSA-351869) CASP8(385-479) [mitochondrial outer membrane] (R-HSA-351828) CASP8(385-479) [cytosol] (R-HSA-76158) CASP8(375-384) [cytosol] (R-HSA-933460) CASP8(217-374) [cytosol] (R-HSA-75975) CASP8(1-216) [cytosol] (R-HSA-933456) CASP8(1-479) [cytosol] (R-HSA-57031)	0.524	3
UniProt:P08069 IGF1R	3	IGF1R(741-1367) [plasma membrane] (R-HSA-2404180) IGF1R(31-736) [plasma membrane] (R-HSA-2404169) p-Y1161,Y1165,Y1166-IGF1R(741-1367) [plasma membrane] (R-HSA-2404172)	0.508	3
UniProt:Q03135 CAV1	5	CAV1 [Golgi membrane] (R-HSA-204504) CAV1 [plasma membrane] (R-HSA-534994) CAV1 [early endosome membrane] (R-HSA-5368451) CAV1 [lipid droplet] (R-HSA-163510) CAV1 [endocytic vesicle membrane] (R-HSA-535009)	0.499	2
UniProt:O35274 NEB2			0.499	2
UniProt:P11049 CD37			0.499	4
UniProt:P20273 CD22	3	NAc-CD22 [plasma membrane] (R-HSA-5690736) CD22 [plasma membrane] (R-HSA-197703) p-Y762,807,822-CD22 [plasma membrane] (R-HSA-5690726)	0.499	4
UniProt:Q8N1K5 THMS1			0.499	4
UniProt:P32927 CSF2RB	6	CSF2RB S271L [plasma membrane] (R-HSA-5688879) p-Y593,Y628-CSF2RB [plasma membrane] (R-HSA-912312) CSF2RB [plasma membrane] (R-HSA-879960) p-S585-CSF2RB [plasma membrane] (R-HSA-914170) p-Y593-CSF2RB [plasma membrane] (R-HSA-914092) CSF2RB R211Efs*54 [plasma membrane] (R-HSA-5688863)	0.471	2
UniProt:P43626 KIR2DL1	1	KIR2DL1 [plasma membrane] (R-HSA-199538)	0.462	4
UniProt:P27986 PIK3R1	16	p-Y-PIK3R1 [cytosol] (R-HSA-9680647) PIK3R1 G376R [plasma membrane] (R-HSA-2399717) PIK3R1 K379E [plasma membrane] (R-HSA-8944148) PIK3R1 Y463_L466del [plasma membrane] (R-HSA-2399546) PIK3R1 H450_E451del [plasma membrane] (R-HSA-2399545) PIK3R1 R574_T576del [plasma membrane] (R-HSA-2399544) PIK3R1 D560Y [plasma membrane] (R-HSA-2399421) PIK3R1 N564D [plasma membrane] (R-HSA-2399427) PIK3R1 K459del [plasma membrane] (R-HSA-2399554) PIK3R1 N564K [plasma membrane] (R-HSA-2399431) PIK3R1 D560H [plasma membrane] (R-HSA-2399432) PIK3R1 R574I [plasma membrane] (R-HSA-2399536) PIK3R1 R574T [plasma membrane] (R-HSA-2399540) K63polyUb-PIK3R1 [cytosol] (R-HSA-3080572) PIK3R1 [cytosol] (R-HSA-74789) PIK3R1 [plasma membrane] (R-HSA-198365)	0.462	2
UniProt:P78314 3BP2			0.462	2
UniProt:P16284 PECAM1	5	PECAM1 [platelet alpha granule membrane] (R-HSA-61489) PECAM1 [plasma membrane] (R-HSA-114686) PECAM1 [secretory granule membrane] (R-HSA-6804778) p-Y663,Y686-PECAM1(27-?) [plasma membrane] (R-HSA-210007) p-Y713-PECAM1 [plasma membrane] (R-HSA-9860772)	0.462	4

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