Reactome | IL2RB [plasma membrane]

IL2RB [plasma membrane]

Stable Identifier

R-HSA-197876

Type

Protein [EntityWithAccessionedSequence]

Species

Homo sapiens

Compartment

plasma membrane

Synonyms

Interleukin-2 receptor beta chain, IL2B_HUMAN

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Locations in the PathwayBrowser for interactor UniProt:P60568 IL2

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Immune System (Homo sapiens)

- Cytokine Signaling in Immune system (Homo sapiens)
  - Signaling by Interleukins (Homo sapiens)
    - Interleukin-2 family signaling (Homo sapiens)
      - Interleukin-2 signaling (Homo sapiens)
        
        IL2RB binds JAK1 (Homo sapiens)
        
        IL2RB [plasma membrane] (Homo sapiens)

External Reference Information

External Reference

UniProt:P14784 IL2RB

Gene Names

IL2RB, IL15RB

Chain

signal peptide:1-26, chain:27-551

Reference Genes

BioGPS Gene:3560 IL2RB

COSMIC (genes):IL2RB IL2RB

CTD Gene:3560 IL2RB

dbSNP Gene:3560 IL2RB

ENSEMBL:ENSG00000100385 IL2RB

HGNC:6009 IL2RB

KEGG Gene (Homo sapiens):3560 IL2RB

Monarch:3560 IL2RB

NCBI Gene:3560 IL2RB

OMIM:146710 IL2RB

UCSC:P14784 IL2RB

Reference Transcript

Other Identifiers

0005390193

11722635_at

1365_at

16934709

205291_at

3560

3959988

3959989

3959990

3959991

3959992

3959993

3959994

3959995

3959997

3959998

3959999

3960000

3960001

3960002

3960003

7896691

7896708

8075886

A_24_P203000

GE62412

GO:0000165

GO:0003674

GO:0004896

GO:0004911

GO:0005515

GO:0005575

GO:0005622

GO:0005737

GO:0005768

GO:0005829

GO:0005886

GO:0005887

GO:0005893

GO:0006464

GO:0006810

GO:0007165

GO:0008150

GO:0008219

GO:0009897

GO:0009986

GO:0016020

GO:0016021

GO:0016032

GO:0016192

GO:0019221

GO:0019976

GO:0022607

GO:0031410

GO:0032991

GO:0035723

GO:0038110

GO:0042010

GO:0043066

GO:0043226

GO:0044403

GO:0050766

GO:0065003

HMNXSV003043276

ILMN_1684349

M26062_at

PH_hs_0004344

TC22000722.hg

g4504664_3p_at

Participates

as a component of

as an input of

IL2RB binds JAK1 (Homo sapiens)

Other forms of this molecule

p-Y364,Y418,Y536-IL2RB [plasma membrane]

p-Y-IL2RB [cytosol]

IL2RB [endosome]

Inferred To

il2rb [plasma membrane] (Danio rerio)

IL2RB [plasma membrane] (Bos taurus)

IL2RB [plasma membrane] (Canis familiaris)

IL2RB [plasma membrane] (Gallus gallus)

IL2RB [plasma membrane] (Sus scrofa)

Il2rb [plasma membrane] (Mus musculus)

Il2rb [plasma membrane] (Rattus norvegicus)

Cross References

RefSeq

NP_001333152.1, NP_001333151.1, NP_000869.1

Guide to Pharmacology - Targets

1696

OpenTargets

ENSG00000100385

HPA

ENSG00000100385-IL2RB

GeneCards

P14784

Ensembl

ENST00000216223, ENSG00000100385, ENSP00000216223

PRO

P14784

Pharos - Targets

P14784

Orphanet

22169

GlyGen

P14784

PDB

4GS7, 6E8K, 2ERJ, 3QAZ, 1ILN, 2B5I, 1ILM, 5M5E

Interactors (4)

Accession	#Entities	Entities	Confidence Score	Evidence (IntAct)
UniProt:P60568 IL2	1	IL2 [extracellular region] (R-HSA-447099)	0.737	5
UniProt:P40933 IL15	2	IL15 [extracellular region] (R-HSA-447242) IL15 [endosome] (R-HSA-8983123)	0.658	3
UniProt:Q13261 IL15RA	2	IL15RA [endosome] (R-HSA-8983117) IL15RA [plasma membrane] (R-HSA-449122)	0.591	3
UniProt:Q15645 PCH2			0.556	3