Reactome | FCGR1A [plasma membrane]

FCGR1A [plasma membrane]

Stable Identifier

R-HSA-197835

Type

Protein [EntityWithAccessionedSequence]

Species

Homo sapiens

Compartment

plasma membrane

Synonyms

High affinity immunoglobulin gamma Fc receptor IA, FCG1_HUMAN

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Locations in the PathwayBrowser

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Disease (Homo sapiens)

- Infectious disease (Homo sapiens)
  - Parasitic Infection Pathways (Homo sapiens)
    - Leishmania infection (Homo sapiens)
      - Leishmania parasite growth and survival (Homo sapiens)
        
        Anti-inflammatory response favouring Leishmania parasite infection (Homo sapiens)
        
        FCGR3A-mediated IL10 synthesis (Homo sapiens)
        
        Phosphorylation and activation of PLCG due to FCGR3A effect (Homo sapiens)
        
        clustered IgG-Ag:p-FCGRs:p-6Y-SYK:PLCG [plasma membrane] (Homo sapiens)
        
        clustered IgG-Ag:p-FCGRs:p-6Y-SYK [plasma membrane] (Homo sapiens)
        
        clustered IgG-Ag:p-FCGRs [plasma membrane] (Homo sapiens)
        
        p-FCGRs [plasma membrane] (Homo sapiens)
        
        FCGRIA:p-Y160,Y171-CD3G dimer [plasma membrane] (Homo sapiens)
        
        FCGR1A [plasma membrane] (Homo sapiens)

Immune System (Homo sapiens)

- Adaptive Immune System (Homo sapiens)
  - Class I MHC mediated antigen processing & presentation (Homo sapiens)
    - Antigen processing-Cross presentation (Homo sapiens)
      - Cross-presentation of soluble exogenous antigens (endosomes) (Homo sapiens)
        
        Interaction of exogenous soluble antigen with its corresponding receptor (Homo sapiens)
        
        MR/other probable receptors [plasma membrane] (Homo sapiens)
        
        FCGRA [plasma membrane] (Homo sapiens)
        
        FCGR1A [plasma membrane] (Homo sapiens)
        
        MR:soluble antigen [plasma membrane] (Homo sapiens)
        
        MR/other probable receptors [plasma membrane] (Homo sapiens)
        
        FCGRA [plasma membrane] (Homo sapiens)
        
        FCGR1A [plasma membrane] (Homo sapiens)
        
        Internalization of receptor bound antigen into clathrin coted vesicles (Homo sapiens)
        
        MR:soluble antigen [plasma membrane] (Homo sapiens)
        
        MR/other probable receptors [plasma membrane] (Homo sapiens)
        
        FCGRA [plasma membrane] (Homo sapiens)
        
        FCGR1A [plasma membrane] (Homo sapiens)
  - Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell (Homo sapiens)
    - CMVPP65 binds NCR3 (Homo sapiens)
      - CMVPP65:NCR3:FCRG3A:CD3Z dimer [plasma membrane] (Homo sapiens)
        
        NCR3:FCRG1A:CD3Z dimer [plasma membrane] (Homo sapiens)
        
        FCRG1A:CD3Z dimer [plasma membrane] (Homo sapiens)
        
        FCGR1A [plasma membrane] (Homo sapiens)
      - NCR3:FCRG1A:CD3Z dimer [plasma membrane] (Homo sapiens)
        
        FCRG1A:CD3Z dimer [plasma membrane] (Homo sapiens)
        
        FCGR1A [plasma membrane] (Homo sapiens)
    - NCR3LG1 binds NCR3 (Homo sapiens)
      - NCR3:FCRG1A:CD3Z dimer [plasma membrane] (Homo sapiens)
        
        FCRG1A:CD3Z dimer [plasma membrane] (Homo sapiens)
        
        FCGR1A [plasma membrane] (Homo sapiens)
      - NCR3LG1:NCR3:FCRG3A:CD3Z dimer [plasma membrane] (Homo sapiens)
        
        NCR3:FCRG1A:CD3Z dimer [plasma membrane] (Homo sapiens)
        
        FCRG1A:CD3Z dimer [plasma membrane] (Homo sapiens)
        
        FCGR1A [plasma membrane] (Homo sapiens)
    - viral HA binds NCRI (Homo sapiens)
      - NCR1:FCRG1A:CD3Z dimer [plasma membrane] (Homo sapiens)
        
        FCRG1A:CD3Z dimer [plasma membrane] (Homo sapiens)
        
        FCGR1A [plasma membrane] (Homo sapiens)
      - NCR1:FCRG1A:CD3Z dimer:Hemagglutinin [plasma membrane] (Homo sapiens)
        
        NCR1:FCRG1A:CD3Z dimer [plasma membrane] (Homo sapiens)
        
        FCRG1A:CD3Z dimer [plasma membrane] (Homo sapiens)
        
        FCGR1A [plasma membrane] (Homo sapiens)
- Cytokine Signaling in Immune system (Homo sapiens)
  - Interferon Signaling (Homo sapiens)
    - Interferon gamma signaling (Homo sapiens)
      - Expression of IFNG-stimulated genes (Homo sapiens)
        
        FCGRA [plasma membrane] (Homo sapiens)
        
        FCGR1A [plasma membrane] (Homo sapiens)
- Innate Immune System (Homo sapiens)
  - Fcgamma receptor (FCGR) dependent phagocytosis (Homo sapiens)
    - FCGR activation (Homo sapiens)
      - Cross-linking of FCGRIA with IgG-coated Ag (Homo sapiens)
        
        FCGRIA:CD3G homodimer [plasma membrane] (Homo sapiens)
        
        FCGR1A [plasma membrane] (Homo sapiens)
        
        IgG-Ag:FCGRIA:CD3G homodimer [plasma membrane] (Homo sapiens)
        
        FCGRIA:CD3G homodimer [plasma membrane] (Homo sapiens)
        
        FCGR1A [plasma membrane] (Homo sapiens)
      - Phosphorylation of SYK by Src kinases (Homo sapiens)
        
        clustered IgG-Ag:p-FCGRs:SYK [plasma membrane] (Homo sapiens)
        
        clustered IgG-Ag:p-FCGRs [plasma membrane] (Homo sapiens)
        
        p-FCGRs [plasma membrane] (Homo sapiens)
        
        FCGRIA:p-Y160,Y171-CD3G dimer [plasma membrane] (Homo sapiens)
        
        FCGR1A [plasma membrane] (Homo sapiens)
        
        clustered IgG-Ag:p-FCGRs:p-6Y-SYK [plasma membrane] (Homo sapiens)
        
        clustered IgG-Ag:p-FCGRs [plasma membrane] (Homo sapiens)
        
        p-FCGRs [plasma membrane] (Homo sapiens)
        
        FCGRIA:p-Y160,Y171-CD3G dimer [plasma membrane] (Homo sapiens)
        
        FCGR1A [plasma membrane] (Homo sapiens)
      - Recruitment of SYK to phosphorylated ITAMs (Homo sapiens)
        
        clustered IgG-Ag:p-FCGRs [plasma membrane] (Homo sapiens)
        
        p-FCGRs [plasma membrane] (Homo sapiens)
        
        FCGRIA:p-Y160,Y171-CD3G dimer [plasma membrane] (Homo sapiens)
        
        FCGR1A [plasma membrane] (Homo sapiens)
        
        clustered IgG-Ag:p-FCGRs:SYK [plasma membrane] (Homo sapiens)
        
        clustered IgG-Ag:p-FCGRs [plasma membrane] (Homo sapiens)
        
        p-FCGRs [plasma membrane] (Homo sapiens)
        
        FCGRIA:p-Y160,Y171-CD3G dimer [plasma membrane] (Homo sapiens)
        
        FCGR1A [plasma membrane] (Homo sapiens)
      - Sequestering and phosphorylation Fc gamma receptors in the lipid rafts (Homo sapiens)
        
        clustered IgG-Ag:FCGRs [plasma membrane] (Homo sapiens)
        
        FCGRs [plasma membrane] (Homo sapiens)
        
        FCGRIA:CD3G homodimer [plasma membrane] (Homo sapiens)
        
        FCGR1A [plasma membrane] (Homo sapiens)
        
        clustered IgG-Ag:p-FCGRs [plasma membrane] (Homo sapiens)
        
        p-FCGRs [plasma membrane] (Homo sapiens)
        
        FCGRIA:p-Y160,Y171-CD3G dimer [plasma membrane] (Homo sapiens)
        
        FCGR1A [plasma membrane] (Homo sapiens)
    - Regulation of actin dynamics for phagocytic cup formation (Homo sapiens)
      - Activation of RAC1 by CRKII:DOCK180:ELMO (Homo sapiens)
        
        CRKII:DOCK180:ELMO complex recruited to phagocytic cup [plasma membrane] (Homo sapiens)
        
        clustered IgG-Ag:p-FCGRs:p-6Y-SYK [plasma membrane] (Homo sapiens)
        
        clustered IgG-Ag:p-FCGRs [plasma membrane] (Homo sapiens)
        
        p-FCGRs [plasma membrane] (Homo sapiens)
        
        FCGRIA:p-Y160,Y171-CD3G dimer [plasma membrane] (Homo sapiens)
        
        FCGR1A [plasma membrane] (Homo sapiens)
      - Activation of RAC1 by VAV (Homo sapiens)
        
        clustered IgG-Ag:p-FCGRs:p-6Y-SYK:p-VAV [plasma membrane] (Homo sapiens)
        
        clustered IgG-Ag:p-FCGRs:p-6Y-SYK [plasma membrane] (Homo sapiens)
        
        clustered IgG-Ag:p-FCGRs [plasma membrane] (Homo sapiens)
        
        p-FCGRs [plasma membrane] (Homo sapiens)
        
        FCGRIA:p-Y160,Y171-CD3G dimer [plasma membrane] (Homo sapiens)
        
        FCGR1A [plasma membrane] (Homo sapiens)
      - Phosphorylation of VAV (Homo sapiens)
        
        clustered IgG-Ag:p-FCGRs:p-6Y-SYK [plasma membrane] (Homo sapiens)
        
        clustered IgG-Ag:p-FCGRs [plasma membrane] (Homo sapiens)
        
        p-FCGRs [plasma membrane] (Homo sapiens)
        
        FCGRIA:p-Y160,Y171-CD3G dimer [plasma membrane] (Homo sapiens)
        
        FCGR1A [plasma membrane] (Homo sapiens)
        
        clustered IgG-Ag:p-FCGRs:p-6Y-SYK:VAV [plasma membrane] (Homo sapiens)
        
        clustered IgG-Ag:p-FCGRs:p-6Y-SYK [plasma membrane] (Homo sapiens)
        
        clustered IgG-Ag:p-FCGRs [plasma membrane] (Homo sapiens)
        
        p-FCGRs [plasma membrane] (Homo sapiens)
        
        FCGRIA:p-Y160,Y171-CD3G dimer [plasma membrane] (Homo sapiens)
        
        FCGR1A [plasma membrane] (Homo sapiens)
        
        clustered IgG-Ag:p-FCGRs:p-6Y-SYK:p-VAV [plasma membrane] (Homo sapiens)
        
        clustered IgG-Ag:p-FCGRs:p-6Y-SYK [plasma membrane] (Homo sapiens)
        
        clustered IgG-Ag:p-FCGRs [plasma membrane] (Homo sapiens)
        
        p-FCGRs [plasma membrane] (Homo sapiens)
        
        FCGRIA:p-Y160,Y171-CD3G dimer [plasma membrane] (Homo sapiens)
        
        FCGR1A [plasma membrane] (Homo sapiens)
      - Recruitment of CRKII:DOCK180:ELMO complex to FCGR (Homo sapiens)
        
        CRKII:DOCK180:ELMO complex recruited to phagocytic cup [plasma membrane] (Homo sapiens)
        
        clustered IgG-Ag:p-FCGRs:p-6Y-SYK [plasma membrane] (Homo sapiens)
        
        clustered IgG-Ag:p-FCGRs [plasma membrane] (Homo sapiens)
        
        p-FCGRs [plasma membrane] (Homo sapiens)
        
        FCGRIA:p-Y160,Y171-CD3G dimer [plasma membrane] (Homo sapiens)
        
        FCGR1A [plasma membrane] (Homo sapiens)
        
        clustered IgG-Ag:p-FCGRs:p-6Y-SYK [plasma membrane] (Homo sapiens)
        
        clustered IgG-Ag:p-FCGRs [plasma membrane] (Homo sapiens)
        
        p-FCGRs [plasma membrane] (Homo sapiens)
        
        FCGRIA:p-Y160,Y171-CD3G dimer [plasma membrane] (Homo sapiens)
        
        FCGR1A [plasma membrane] (Homo sapiens)
      - Recruitment of VAV1 to p-6Y-SYK (Homo sapiens)
        
        clustered IgG-Ag:p-FCGRs:p-6Y-SYK [plasma membrane] (Homo sapiens)
        
        clustered IgG-Ag:p-FCGRs [plasma membrane] (Homo sapiens)
        
        p-FCGRs [plasma membrane] (Homo sapiens)
        
        FCGRIA:p-Y160,Y171-CD3G dimer [plasma membrane] (Homo sapiens)
        
        FCGR1A [plasma membrane] (Homo sapiens)
        
        clustered IgG-Ag:p-FCGRs:p-6Y-SYK:VAV [plasma membrane] (Homo sapiens)
        
        clustered IgG-Ag:p-FCGRs:p-6Y-SYK [plasma membrane] (Homo sapiens)
        
        clustered IgG-Ag:p-FCGRs [plasma membrane] (Homo sapiens)
        
        p-FCGRs [plasma membrane] (Homo sapiens)
        
        FCGRIA:p-Y160,Y171-CD3G dimer [plasma membrane] (Homo sapiens)
        
        FCGR1A [plasma membrane] (Homo sapiens)
      - Role of myosins in phagosome formation (Homo sapiens)
        
        clustered IgG-Ag:p-FCGRs [phagocytic cup] (Homo sapiens)
        
        p-FCGRs [plasma membrane] (Homo sapiens)
        
        FCGRIA:p-Y160,Y171-CD3G dimer [plasma membrane] (Homo sapiens)
        
        FCGR1A [plasma membrane] (Homo sapiens)
        
        clustered IgG-Ag:p-FCGRs [plasma membrane] (Homo sapiens)
        
        p-FCGRs [plasma membrane] (Homo sapiens)
        
        FCGRIA:p-Y160,Y171-CD3G dimer [plasma membrane] (Homo sapiens)
        
        FCGR1A [plasma membrane] (Homo sapiens)
    - Role of phospholipids in phagocytosis (Homo sapiens)
      - PI3K binds to p-6Y-SYK (Homo sapiens)
        
        PI3K:p-6Y-SYK [plasma membrane] (Homo sapiens)
        
        clustered IgG-Ag:p-FCGRs:p-6Y-SYK [plasma membrane] (Homo sapiens)
        
        clustered IgG-Ag:p-FCGRs [plasma membrane] (Homo sapiens)
        
        p-FCGRs [plasma membrane] (Homo sapiens)
        
        FCGRIA:p-Y160,Y171-CD3G dimer [plasma membrane] (Homo sapiens)
        
        FCGR1A [plasma membrane] (Homo sapiens)
        
        clustered IgG-Ag:p-FCGRs:p-6Y-SYK [plasma membrane] (Homo sapiens)
        
        clustered IgG-Ag:p-FCGRs [plasma membrane] (Homo sapiens)
        
        p-FCGRs [plasma membrane] (Homo sapiens)
        
        FCGRIA:p-Y160,Y171-CD3G dimer [plasma membrane] (Homo sapiens)
        
        FCGR1A [plasma membrane] (Homo sapiens)
      - PI3K phosphorylates PIP2 to PIP3 (Homo sapiens)
        
        PI3K:p-6Y-SYK [plasma membrane] (Homo sapiens)
        
        clustered IgG-Ag:p-FCGRs:p-6Y-SYK [plasma membrane] (Homo sapiens)
        
        clustered IgG-Ag:p-FCGRs [plasma membrane] (Homo sapiens)
        
        p-FCGRs [plasma membrane] (Homo sapiens)
        
        FCGRIA:p-Y160,Y171-CD3G dimer [plasma membrane] (Homo sapiens)
        
        FCGR1A [plasma membrane] (Homo sapiens)
      - Phosphorylation and activation of PLCG (Homo sapiens)
        
        clustered IgG-Ag:p-FCGRs:p-6Y-SYK:PLCG [plasma membrane] (Homo sapiens)
        
        clustered IgG-Ag:p-FCGRs:p-6Y-SYK [plasma membrane] (Homo sapiens)
        
        clustered IgG-Ag:p-FCGRs [plasma membrane] (Homo sapiens)
        
        p-FCGRs [plasma membrane] (Homo sapiens)
        
        FCGRIA:p-Y160,Y171-CD3G dimer [plasma membrane] (Homo sapiens)
        
        FCGR1A [plasma membrane] (Homo sapiens)
        
        clustered IgG-Ag:p-FCGRs:p-6Y-SYK:p-3Y-PLCG [plasma membrane] (Homo sapiens)
        
        clustered IgG-Ag:p-FCGRs:p-6Y-SYK [plasma membrane] (Homo sapiens)
        
        clustered IgG-Ag:p-FCGRs [plasma membrane] (Homo sapiens)
        
        p-FCGRs [plasma membrane] (Homo sapiens)
        
        FCGRIA:p-Y160,Y171-CD3G dimer [plasma membrane] (Homo sapiens)
        
        FCGR1A [plasma membrane] (Homo sapiens)
      - Recruitment of PLCgamma to membrane (Homo sapiens)
        
        clustered IgG-Ag:p-FCGRs:p-6Y-SYK [plasma membrane] (Homo sapiens)
        
        clustered IgG-Ag:p-FCGRs [plasma membrane] (Homo sapiens)
        
        p-FCGRs [plasma membrane] (Homo sapiens)
        
        FCGRIA:p-Y160,Y171-CD3G dimer [plasma membrane] (Homo sapiens)
        
        FCGR1A [plasma membrane] (Homo sapiens)
        
        clustered IgG-Ag:p-FCGRs:p-6Y-SYK:PLCG [plasma membrane] (Homo sapiens)
        
        clustered IgG-Ag:p-FCGRs:p-6Y-SYK [plasma membrane] (Homo sapiens)
        
        clustered IgG-Ag:p-FCGRs [plasma membrane] (Homo sapiens)
        
        p-FCGRs [plasma membrane] (Homo sapiens)
        
        FCGRIA:p-Y160,Y171-CD3G dimer [plasma membrane] (Homo sapiens)
        
        FCGR1A [plasma membrane] (Homo sapiens)
      - Release of PLCG from FCGR (Homo sapiens)
        
        clustered IgG-Ag:p-FCGRs:p-6Y-SYK [plasma membrane] (Homo sapiens)
        
        clustered IgG-Ag:p-FCGRs [plasma membrane] (Homo sapiens)
        
        p-FCGRs [plasma membrane] (Homo sapiens)
        
        FCGRIA:p-Y160,Y171-CD3G dimer [plasma membrane] (Homo sapiens)
        
        FCGR1A [plasma membrane] (Homo sapiens)
        
        clustered IgG-Ag:p-FCGRs:p-6Y-SYK:p-3Y-PLCG [plasma membrane] (Homo sapiens)
        
        clustered IgG-Ag:p-FCGRs:p-6Y-SYK [plasma membrane] (Homo sapiens)
        
        clustered IgG-Ag:p-FCGRs [plasma membrane] (Homo sapiens)
        
        p-FCGRs [plasma membrane] (Homo sapiens)
        
        FCGRIA:p-Y160,Y171-CD3G dimer [plasma membrane] (Homo sapiens)
        
        FCGR1A [plasma membrane] (Homo sapiens)

External Reference Information

External Reference

UniProt:P12314 FCGR1A

Gene Names

FCGR1A, FCG1, FCGR1, IGFR1

Chain

signal peptide:1-15, chain:16-374

Reference Genes

BioGPS Gene:2209 FCGR1A

COSMIC (genes):FCGR1A FCGR1A

CTD Gene:2209 FCGR1A

dbSNP Gene:2209 FCGR1A

ENSEMBL:ENSG00000150337 FCGR1A

ENSEMBL_homo_sapiens_GENE:ENSG00000150337.14 FCGR1A

HGNC:3613 FCGR1A

KEGG Gene (Homo sapiens):2209 FCGR1A

Monarch:2209 FCGR1A

NCBI Gene:2209 FCGR1A

OMIM:146760 FCGR1A

UCSC:P12314 FCGR1A

Reference Transcript

RefSeq:NM_000566.3 FCGR1A

Other Identifiers

11736311_x_at

16670367

214511_PM_x_at

214511_x_at

216950_PM_s_at

216950_s_at

2209

2357856

2357857

2357859

2357862

2357863

2357867

2357868

2357869

37220_at

7905047

7905060

7919133

A_14_P110375

A_14_P119044

A_21_P0010561

A_23_P63390

GE60514

GO:0001788

GO:0001798

GO:0001805

GO:0002376

GO:0004888

GO:0005515

GO:0005768

GO:0005886

GO:0006898

GO:0006910

GO:0006911

GO:0006954

GO:0006955

GO:0007165

GO:0007166

GO:0009617

GO:0009897

GO:0016020

GO:0016192

GO:0019770

GO:0019771

GO:0019864

GO:0019884

GO:0023052

GO:0030669

GO:0031410

GO:0031901

GO:0036211

GO:0038094

GO:0042590

GO:0042742

GO:0043226

GO:0045087

GO:0050766

GO:0050776

GO:0060089

GO:0061024

GO:0061098

GO:0098542

HMNXSV003021824

Hs.77424.1.S1_3p_s_at

Hs.77424.2.S1_3p_a_at

ILMN_2176063

ILMN_2261600

M63835_at

PH_hs_0035290

TC01001172.hg

TC01003057.hg

TC01004727.hg

Participates

as a component of

as a member of

FCGRA [plasma membrane] (Homo sapiens)

Other forms of this molecule

FCGR1A [clathrin-coated endocytic vesicle membrane]

FCGR1A [early endosome membrane]

Inferred To

Fcgr1a [plasma membrane] (Rattus norvegicus)

LOC105948225 [plasma membrane] (Xenopus tropicalis)

FCGR1A [plasma membrane] (Bos taurus)

FCGR1A [plasma membrane] (Canis familiaris)

FCGR1A [plasma membrane] (Gallus gallus)

FCGR1A [plasma membrane] (Sus scrofa)

Homologues of FCGR1A [plasma membrane] (Xenopus tropicalis)

LOC100494132 [plasma membrane] (Xenopus tropicalis)

Fcgr1 [plasma membrane] (Mus musculus)

Cross References

RefSeq

NP_000557.1

OpenTargets

ENSG00000150337

HPA

ENSG00000150337-FCGR1A

ZINC - Substances

FCGR1_HUMAN

GeneCards

P12314

ZINC target

P12314

Ensembl

ENSP00000358165, ENST00000369168, ENSG00000150337

PRO

P12314

Pharos - Targets

P12314

ZINC - Predictions - Purchasable

FCGR1_HUMAN

PDB

8DJ7, 4W4O, 8DIR, 8DIN, 4X4M, 3RJD, 4ZNE

Interactors (2)

Accession	#Entities	Entities	Confidence Score	Evidence (IntAct)
UniProt:Q86VB7 CD163	5	CD163(1051-1156) [plasma membrane] (R-HSA-9662797) sCD163 [extracellular region] (R-HSA-9662833) sCD163 [cytosol] (R-HSA-9663456) CD163 [endocytic vesicle membrane] (R-HSA-2230974) CD163 [plasma membrane] (R-HSA-2168868)	0.556	3
UniProt:Q15848 ADIPOQ	1	ADIPOQ [extracellular region] (R-HSA-1183052)	0.556	3

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