ERBB4 forms heterodimers with EGFR

Stable Identifier
Reaction [binding]
Homo sapiens
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Ligand-stimulated ERBB4 was shown to form heterodimers with ligand-stimulated EGFR when human ERBB4 and EGFR were exogenously expressed in mouse fibroblast cell line. Heterodimers of ERBB4 and EGFR undergo trans-autophosphorylation, but the exact phosphorylation pattern, downstream signaling and physiological significance of these heterodimers have not been studied (Riese et al. 1995, Cohen et al. 1996). Binding of ERBB4 CYT2 isoform to EGFR protects EGFR from ligand-induced degradation by preventing binding of the CBL:GRB2 complex to EGFR (Kiuchi et al. 2014).

Literature References
PubMed ID Title Journal Year
8617750 HER4-mediated biological and biochemical properties in NIH 3T3 cells. Evidence for HER1-HER4 heterodimers

Cohen, BD, Green, JM, Foy, L, Fell, HP

J Biol Chem 1996
7565730 The cellular response to neuregulins is governed by complex interactions of the erbB receptor family

Riese DJ, 2nd, van Raaij, TM, Plowman, GD, Andrews, GC, Stern, DF

Mol Cell Biol 1995
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Orthologous Events