Reactome | ERBB4 forms heterodimers with EGFR

ERBB4 forms heterodimers with EGFR

Stable Identifier

R-HSA-1977959

Type

Reaction [binding]

Species

Homo sapiens

Compartment

plasma membrane, extracellular region

ReviewStatus

5/5

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Ligand-stimulated ERBB4 was shown to form heterodimers with ligand-stimulated EGFR when human ERBB4 and EGFR were exogenously expressed in mouse fibroblast cell line. Heterodimers of ERBB4 and EGFR undergo trans-autophosphorylation, but the exact phosphorylation pattern, downstream signaling and physiological significance of these heterodimers have not been studied (Riese et al. 1995, Cohen et al. 1996). Binding of ERBB4 CYT2 isoform to EGFR protects EGFR from ligand-induced degradation by preventing binding of the CBL:GRB2 complex to EGFR (Kiuchi et al. 2014).

Literature References

PubMed ID	Title	Journal	Year
7565730	The cellular response to neuregulins is governed by complex interactions of the erbB receptor family Riese DJ, 2nd, van Raaij, TM, Plowman, GD, Andrews, GC, Stern, DF	Mol Cell Biol	1995
8617750	HER4-mediated biological and biochemical properties in NIH 3T3 cells. Evidence for HER1-HER4 heterodimers Cohen, BD, Green, JM, Foy, L, Fell, HP	J Biol Chem	1996