Reactome | TREM2 [plasma membrane]

TREM2 [plasma membrane]

Stable Identifier

R-HSA-197664

Type

Protein [EntityWithAccessionedSequence]

Species

Homo sapiens

Compartment

plasma membrane

Synonyms

Triggering receptor expressed on myeloid cells 2 precursor, TMR2_HUMAN

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Locations in the PathwayBrowser

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Developmental Biology (Homo sapiens)

- Nervous system development (Homo sapiens)
  - Axon guidance (Homo sapiens)
    - Semaphorin interactions (Homo sapiens)
      - Other semaphorin interactions (Homo sapiens)
        
        SEMA6D binds to PLXNA1:TREM2:DAP12 (Homo sapiens)
        
        PLXNA1:TREM2:DAP12 [plasma membrane] (Homo sapiens)
        
        DAP12 dimer:TREM2 [plasma membrane] (Homo sapiens)
        
        TREM2 [plasma membrane] (Homo sapiens)
        
        SEMA6D:PLXNA1:TREM2:DAP12 [plasma membrane] (Homo sapiens)
        
        PLXNA1:TREM2:DAP12 [plasma membrane] (Homo sapiens)
        
        DAP12 dimer:TREM2 [plasma membrane] (Homo sapiens)
        
        TREM2 [plasma membrane] (Homo sapiens)

External Reference Information

External Reference

UniProt:Q9NZC2 TREM2

Gene Names

TREM2

Chain

signal peptide:1-18, chain:19-230

Reference Genes

BioGPS Gene:54209 TREM2

COSMIC (genes):TREM2 TREM2

CTD Gene:54209 TREM2

dbSNP Gene:54209 TREM2

ENSEMBL:ENSG00000095970 TREM2

HGNC:17761 TREM2

KEGG:hsa:54209 TREM2

Monarch:54209 TREM2

NCBI Gene:54209 TREM2

OMIM:605086 TREM2

UCSC:Q9NZC2 TREM2

Reference Transcript

Other Identifiers

11723803_a_at

11745612_a_at

17019029

219725_PM_at

219725_at

2953498

2953500

2953502

2953503

2953505

2953506

2953507

2953508

2953509

2953510

2953511

2953512

2953513

2953514

45599_at

54209

8126279

A_23_P167941

A_24_P12397

GE61783

GO:0001530

GO:0001540

GO:0001774

GO:0001786

GO:0001934

GO:0002116

GO:0002282

GO:0002291

GO:0002376

GO:0002588

GO:0002862

GO:0002931

GO:0004888

GO:0005515

GO:0005543

GO:0005576

GO:0005886

GO:0006910

GO:0006911

GO:0006954

GO:0006959

GO:0007613

GO:0008013

GO:0008035

GO:0008289

GO:0008429

GO:0010468

GO:0010507

GO:0010628

GO:0010875

GO:0010887

GO:0010891

GO:0010983

GO:0012501

GO:0016020

GO:0016192

GO:0017154

GO:0019209

GO:0019216

GO:0030154

GO:0030169

GO:0030215

GO:0030316

GO:0032006

GO:0032008

GO:0032497

GO:0032499

GO:0032675

GO:0032691

GO:0032720

GO:0032733

GO:0033674

GO:0034136

GO:0034144

GO:0034151

GO:0034185

GO:0034186

GO:0034189

GO:0034241

GO:0034330

GO:0034351

GO:0035176

GO:0038023

GO:0038160

GO:0042742

GO:0042834

GO:0043066

GO:0043124

GO:0043277

GO:0044853

GO:0044877

GO:0045088

GO:0045672

GO:0045728

GO:0045960

GO:0048143

GO:0048678

GO:0050714

GO:0050730

GO:0050731

GO:0050766

GO:0050829

GO:0050850

GO:0050866

GO:0050877

GO:0050921

GO:0051897

GO:0051898

GO:0055088

GO:0060075

GO:0060089

GO:0060100

GO:0061024

GO:0061518

GO:0061889

GO:0070269

GO:0070345

GO:0070374

GO:0070392

GO:0070891

GO:0071223

GO:0071224

GO:0071333

GO:0071396

GO:0071402

GO:0071456

GO:0071526

GO:0071640

GO:0071813

GO:0097028

GO:0097062

GO:0097110

GO:0097242

GO:0098542

GO:0098657

GO:0098772

GO:0110089

GO:0120035

GO:0120146

GO:0140052

GO:0150062

GO:0150076

GO:0150078

GO:0150079

GO:0150094

GO:1900015

GO:1900016

GO:1900223

GO:1900226

GO:1901076

GO:1901224

GO:1901800

GO:1901980

GO:1902227

GO:1902531

GO:1903078

GO:1903082

GO:1903376

GO:1903753

GO:1903980

GO:1904093

GO:1904141

GO:1904646

GO:1904951

GO:1905291

GO:1905581

GO:1905805

GO:1905808

GO:1905907

GO:1990782

GO:2000350

GO:2001171

HMNXSV003020680

HMNXSV003043445

ILMN_1701248

PH_hs_0020407

PH_hs_0035985

TC06001713.hg

g9507202_3p_at

Participates

as a member of

as a component of

DAP12 dimer:TREM2 [plasma membrane] (Homo sapiens)

as an input of

Interaction of DAP12 and TREM2 (Homo sapiens)

Inferred To

Homologues of TREM2 [plasma membrane] (Gallus gallus)

si:ch211-264f5.2 [plasma membrane] (Danio rerio)

LOC119863908 [plasma membrane] (Canis familiaris)

LOC100490037 [plasma membrane] (Xenopus tropicalis)

CD300LG [plasma membrane] (Gallus gallus)

Trem2 [plasma membrane] (Rattus norvegicus)

TREM2 [plasma membrane] (Bos taurus)

TREM2 [plasma membrane] (Mus musculus)

TREM2 [plasma membrane] (Sus scrofa)

KRABZFP [plasma membrane] (Gallus gallus)

Cross References

RefSeq

NP_001258750.1, NP_061838.1

OpenTargets

ENSG00000095970

ENSEMBL

ENST00000373122, ENSP00000362214, ENST00000373113, ENSP00000342651, ENSG00000095970, ENST00000338469, ENSP00000362205

HPA

ENSG00000095970-TREM2

GeneCards

TREM2

PRO

Q9NZC2

Pharos - Targets

Q9NZC2

Orphanet

TREM2

GlyGen

Q9NZC2

PDB

8T59, 6Z0H, 6Z0I, 8T51, 6Z0G, 5ELI, 6Y6C, 6XDS, 5UD8, 6YYE, 5UD7, 6YMQ, 6B8O

HMDB Protein

HMDBP13856

Interactors (5)

Accession	#Entities	Entities	Confidence Score	Evidence (IntAct)
UniProt:O43914 TYROBP	3	p-Y91,Y102-TYROBP [plasma membrane] (R-HSA-210010) TYROBP [plasma membrane] (R-HSA-198087) TYROBP [secretory granule membrane] (R-HSA-6804800)	0.667	4
UniProt:P05067-PRO_0000000092 APP			0.611	4
IntAct:EBI-14348029 ABETA-42-OLIGOMER			0.611	3
UniProt:P02649 APOE	10	APOE [extracellular region] (R-HSA-174646) APOE [endoplasmic reticulum lumen] (R-HSA-6784908) p-APOE [endoplasmic reticulum lumen] (R-HSA-8956980) APOE [endocytic vesicle lumen] (R-HSA-3221641) APOE-4 [extracellular region] (R-HSA-9711070) APOE [plasma membrane] (R-HSA-174615) APOE [clathrin-coated endocytic vesicle membrane] (R-HSA-174651) APOE [endosome membrane] (R-HSA-174766) APOE [endosome lumen] (R-HSA-174804) APOE [early endosome] (R-HSA-2429687)	0.602	4
UniProt:P49768 PSEN1	6	PSEN1(299-467) [plasma membrane] (R-HSA-2534245) PSEN1(1-298) [plasma membrane] (R-HSA-2534298) PSEN1(1-298) [azurophil granule membrane] (R-HSA-6799209) PSEN1(1-467) [azurophil granule membrane] (R-HSA-6799235) PSEN1(299-467) [azurophil granule membrane] (R-HSA-6799234) PSEN1(1-467) [plasma membrane] (R-HSA-201606)	0.599	5

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