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UNC5B [plasma membrane]
Stable Identifier
R-HSA-197559
Type
Protein [EntityWithAccessionedSequence]
Species
Homo sapiens
Compartment
plasma membrane
Synonyms
Netrin receptor UNC5B, UN5B_HUMAN
Locations in the PathwayBrowser
Expand all
Developmental Biology (Homo sapiens)
Nervous system development (Homo sapiens)
Axon guidance (Homo sapiens)
Netrin-1 signaling (Homo sapiens)
Netrin mediated repulsion signals (Homo sapiens)
DCC heterodimerizes with UNC-5:Netrin-1 (Homo sapiens)
DCC:NTN1:UNC5 [plasma membrane] (Homo sapiens)
NTN1:UNC5 [plasma membrane] (Homo sapiens)
UNC5 [plasma membrane] (Homo sapiens)
UNC5B [plasma membrane] (Homo sapiens)
NTN1:UNC5 [plasma membrane] (Homo sapiens)
UNC5 [plasma membrane] (Homo sapiens)
UNC5B [plasma membrane] (Homo sapiens)
UNC-5 binds Netrin-1 (Homo sapiens)
NTN1:UNC5 [plasma membrane] (Homo sapiens)
UNC5 [plasma membrane] (Homo sapiens)
UNC5B [plasma membrane] (Homo sapiens)
UNC5 [plasma membrane] (Homo sapiens)
UNC5B [plasma membrane] (Homo sapiens)
PIKE-L interaction with UNC5B (Homo sapiens)
UNC5B [plasma membrane] (Homo sapiens)
UNC5B:AGAP2 [plasma membrane] (Homo sapiens)
UNC5B [plasma membrane] (Homo sapiens)
Programmed Cell Death (Homo sapiens)
Apoptosis (Homo sapiens)
Caspase activation via extrinsic apoptotic signalling pathway (Homo sapiens)
Caspase activation via Dependence Receptors in the absence of ligand (Homo sapiens)
Caspase cleavage of UNC5B (Homo sapiens)
UNC5B [plasma membrane] (Homo sapiens)
External Reference Information
External Reference
UniProt:Q8IZJ1 UNC5B
Gene Names
UNC5B, P53RDL1, UNC5H2, UNQ1883/PRO4326
Chain
signal peptide:1-26, chain:27-945
Reference Genes
BioGPS Gene:219699 UNC5B
COSMIC (genes):UNC5B UNC5B
CTD Gene:219699 UNC5B
dbSNP Gene:219699 UNC5B
ENSEMBL:ENSG00000107731 UNC5B
HGNC:12568 UNC5B
KEGG:hsa:219699 UNC5B
Monarch:219699 UNC5B
NCBI Gene:219699 UNC5B
OMIM:607870 UNC5B
UCSC:Q8IZJ1 UNC5B
Reference Transcript
RefSeq:NM_170744.4 UNC5B
RefSeq:NM_001244889.1 UNC5B
Other Identifiers
11727068_at
11727069_at
11758968_at
16705810
213100_3p_at
213100_PM_at
213100_at
219699
226899_PM_at
226899_at
3250991
3250992
3251003
3251004
3251005
3251006
3251007
3251008
3251009
3251010
3251011
3251012
3251013
3251014
3251015
3251016
3251017
3251019
3251020
3251021
3251022
41856_PM_at
41856_at
7928189
90745_at
A_14_P116174
A_23_P52336
GE56164
GE573867
GE80026
GO:0001525
GO:0005042
GO:0005515
GO:0005886
GO:0006915
GO:0007165
GO:0012501
GO:0016020
GO:0033564
GO:0038007
GO:0043524
GO:0045121
GO:0051897
GO:0060089
GO:2001240
HMNXSV003031295
Hs.13350.0.S1_3p_at
Hs.13350.0.S1_3p_s_at
Hs.183918.0.A1_3p_at
Hs.183918.0.A1_3p_x_at
ILMN_1692665
ILMN_2176502
PH_hs_0022002
TC10000438.hg
TC10002117.hg
Participates
as a component of
UNC5B:AGAP2 [plasma membrane] (Homo sapiens)
as an input of
PIKE-L interaction with UNC5B (Homo sapiens)
Caspase cleavage of UNC5B (Homo sapiens)
as a member of
UNC5 [plasma membrane] (Homo sapiens)
Other forms of this molecule
UNC5B(413-945) [cytosol]
UNC5B(27-412) [plasma membrane]
Inferred To
UNC5B [plasma membrane]
(Gallus gallus)
unc-5 [plasma membrane]
(Caenorhabditis elegans)
unc-5 [plasma membrane]
(Drosophila melanogaster)
unc5b [plasma membrane]
(Danio rerio)
unc5b [plasma membrane]
(Xenopus tropicalis)
Cross References
ENSEMBL
ENST00000373192
,
ENSP00000334329
,
ENSP00000362288
,
ENSG00000107731
,
ENST00000335350
OpenTargets
ENSG00000107731
GeneCards
UNC5B
HPA
ENSG00000107731-UNC5B
PRO
Q8IZJ1
Pharos - Targets
Q8IZJ1
Interactors (1)
Accession
#Entities
Entities
Confidence Score
Evidence (IntAct)
UniProt:Q8CGU4 Agap2
1
PIKE-L_RAT [cytosol]
(R-RNO-622356)
0.581
9
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