Beta defensin 103 activates TLR1:TLR2

Stable Identifier
R-HSA-1974676
Type
Reaction [binding]
Species
Homo sapiens
Compartment
extracellular region, plasma membrane
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Beta defensin 103 activates TLR1:TLR2
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Beta defensin 103 (hBD-3) can induce expression of the costimulatory molecules CD80, CD86 and CD40 on monocytes and myeloid dendritic cells in a Toll-like receptor (TLR)-dependent manner. Activation by hBD-3 is mediated by an interaction that requires TLRs 1 and 2 (Funderburg et al. 2007, 2011).

Literature References
PubMed ID Title Journal Year
18006661 Human -defensin-3 activates professional antigen-presenting cells via Toll-like receptors 1 and 2

Funderburg, N, Lederman, MM, Feng, Z, Drage, MG, Jadlowsky, J, Harding, CV, Weinberg, A, Sieg, SF

Proc Natl Acad Sci U S A 2007
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Orthologous Events
Beta defensin 103 activates TLR1:TLR2 (Canis familiaris)
Beta defensin 103 activates TLR1:TLR2 (Mus musculus)
Beta defensin 103 activates TLR1:TLR2 (Rattus norvegicus)
Beta defensin 103 activates TLR1:TLR2 (Sus scrofa)
Authored
Jupe, S  (2011-11-07)
Reviewed
McDermott, AM  (2011-11-03)
Created
Jupe, S  (2011-11-07)