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NEDD4 binds ERBB4jmAcyt1s80 dimer
Stable Identifier
R-HSA-1973956
Type
Reaction [binding]
Species
Homo sapiens
Compartment
cytosol
ReviewStatus
5/5
Locations in the PathwayBrowser
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Signal Transduction (Homo sapiens)
Signaling by Receptor Tyrosine Kinases (Homo sapiens)
Signaling by ERBB4 (Homo sapiens)
Downregulation of ERBB4 signaling (Homo sapiens)
NEDD4 binds ERBB4jmAcyt1s80 dimer (Homo sapiens)
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The layout of this reaction may differ from that in the pathway view due to the constraints in pathway layout
E3 ubiquitin ligase NEDD4 binds intracellular domain of ERBB4 isoform JM-A CYT1 (ERBB4jmAcyt1s80) produced by ERBB4 cleavage (Zeng et al. 2009).
Literature References
PubMed ID
Title
Journal
Year
19193720
Nedd4 mediates ErbB4 JM-a/CYT-1 ICD ubiquitination and degradation in MDCK II cells
Harris, RC
,
Zeng, F
,
Xu, J
FASEB J
2009
Participants
Input
ERBB4jmAcyt1s80 dimer [cytosol]
(Homo sapiens)
NEDD4 [cytosol]
(Homo sapiens)
Output
ERBB4jmAcyt1s80:NEDD4 [cytosol]
(Homo sapiens)
Participates
as an event of
Downregulation of ERBB4 signaling (Homo sapiens)
Orthologous Events
NEDD4 binds ERBB4jmAcyt1s80 dimer (Bos taurus)
NEDD4 binds ERBB4jmAcyt1s80 dimer (Caenorhabditis elegans)
NEDD4 binds ERBB4jmAcyt1s80 dimer (Canis familiaris)
NEDD4 binds ERBB4jmAcyt1s80 dimer (Danio rerio)
NEDD4 binds ERBB4jmAcyt1s80 dimer (Drosophila melanogaster)
NEDD4 binds ERBB4jmAcyt1s80 dimer (Gallus gallus)
NEDD4 binds ERBB4jmAcyt1s80 dimer (Mus musculus)
NEDD4 binds ERBB4jmAcyt1s80 dimer (Rattus norvegicus)
NEDD4 binds ERBB4jmAcyt1s80 dimer (Sus scrofa)
Authored
Orlic-Milacic, M (2011-11-04)
Stern, DF (2019-02-21)
Reviewed
Zeng, F (2011-11-11)
Harris, RC (2011-11-11)
Created
Orlic-Milacic, M (2011-11-07)
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