Nicotinamide salvaging

Stable Identifier
Homo sapiens
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Nicotinamide (NAM) levels are modulated by the action of three enzymes involved in nicotinamide salvaging. They are nicotinamide deaminase, nicotinamide phosphoribosyltransferase and nicotinate phosphoribosyltransferase. These enzymes are poorly characterized in humans, depsite their importance in NAM utilization (Magni et al. 2004). Although not a salvage reaction, NAM levels can also be regulated by nicotinamide N-methyltransferase (NNMT), a potential regulator of diet-induced obesity (Kraus et al. 2014).

Literature References
PubMed ID Title Journal Year
14704851 Enzymology of NAD+ homeostasis in man

Magni, G, Amici, A, Emanuelli, M, Orsomando, G, Raffaelli, N, Ruggieri, S

Cell Mol Life Sci 2004
24717514 Nicotinamide N-methyltransferase knockdown protects against diet-induced obesity

Kraus, D, Yang, Q, Kong, D, Banks, AS, Zhang, L, Rodgers, JT, Pirinen, E, Pulinilkunnil, TC, Gong, F, Wang, YC, Cen, Y, Sauve, AA, Asara, JM, Peroni, OD, Monia, BP, Bhanot, S, Alhonen, L, Puigserver, P, Kahn, BB

Nature 2014
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Orthologous Events
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