Reactome | Nicotinamide salvaging

Nicotinamide salvaging

Stable Identifier

R-HSA-197264

Type

Pathway

Species

Homo sapiens

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Nicotinamide (NAM) levels are modulated by the action of three enzymes involved in nicotinamide salvaging. They are nicotinamide deaminase, nicotinamide phosphoribosyltransferase and nicotinate phosphoribosyltransferase. These enzymes are poorly characterized in humans, depsite their importance in NAM utilization (Magni et al. 2004). Although not a salvage reaction, NAM levels can also be regulated by nicotinamide N-methyltransferase (NNMT), a potential regulator of diet-induced obesity (Kraus et al. 2014).

Literature References

PubMed ID	Title	Journal	Year
14704851	Enzymology of NAD+ homeostasis in man Magni, G, Amici, A, Emanuelli, M, Orsomando, G, Raffaelli, N, Ruggieri, S	Cell Mol Life Sci	2004
24717514	Nicotinamide N-methyltransferase knockdown protects against diet-induced obesity Kraus, D, Yang, Q, Kong, D, Banks, AS, Zhang, L, Rodgers, JT, Pirinen, E, Pulinilkunnil, TC, Gong, F, Wang, YC, Cen, Y, Sauve, AA, Asara, JM, Peroni, OD, Monia, BP, Bhanot, S, Alhonen, L, Puigserver, P, Kahn, BB	Nature	2014