Reactome | CHST11,12,13,9 transfer sulfate to (4-)GalNAc

CHST11,12,13,9 transfer sulfate to (4-)GalNAc

Stable Identifier

R-HSA-1971483

Type

Reaction [transition]

Species

Homo sapiens

Compartment

Golgi membrane, Golgi lumen

Synonyms

Chondroitin can be sulfated on position 4 of GalNAc by CHST9, 11, 12 and 13

ReviewStatus

5/5

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CHST11,12,13,9 transfer sulfate to (4-)GalNAc

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Carbohydrate sulfotransferase 11, 12 and 13 (CHST11, 12 and 13, aka C4ST-1, -2 and -3), as well as CHST9, catalyse the transfer of sulfate from PAPS to position 4 of the N-acetylgalactosamine (GalNAc) residue of the chondroitin chain on chondroitin sulfate proteoglycans (CSPG, Kang et al. 2001, Okuda et al. 2000, Hiraoka et al. 2000, Kang et al. 2002 respectively). It is unclear if CHST9, 12, 13 contribute much to this activity in vivo. Mutations in CHST11 can cause bilateral symmetric skeletal defects (OCBMD, MIM:618167; Shabbir et al., 2018).

Literature References

PubMed ID	Title	Journal	Year
11056388	Molecular cloning, expression, and chromosomal mapping of human chondroitin 4-sulfotransferase, whose expression pattern in human tissues is different from that of chondroitin 6-sulfotransferase Okuda, T, Mita, S, Yamauchi, S, Matsubara, T, Yagi, F, Yamamori, D, Fukuta, M, Kuroiwa, A, Matsuda, Y, Habuchi, O	J Biochem	2000
10781601	Molecular cloning and expression of two distinct human chondroitin 4-O-sulfotransferases that belong to the HNK-1 sulfotransferase gene family Hiraoka, N, Nakagawa, H, Ong, E, Akama, TO, Fukuda, MN, Fukuda, M	J Biol Chem	2000
29514872	Homozygous CHST11 mutation in chondrodysplasia, brachydactyly, overriding digits, clino-symphalangism and synpolydactyly Shabbir, RMK, Nalbant, G, Ahmad, N, Malik, S, Tolun, A	J Med Genet	2018
12080076	Molecular cloning and characterization of chondroitin-4-O-sulfotransferase-3. A novel member of the HNK-1 family of sulfotransferases Kang, HG, Evers, MR, Xia, G, Baenziger, JU, Schachner, M	J Biol Chem	2002
11139592	Molecular cloning and expression of an N-acetylgalactosamine-4-O-sulfotransferase that transfers sulfate to terminal and non-terminal beta 1,4-linked N-acetylgalactosamine Kang, HG, Evers, MR, Xia, G, Baenziger, JU, Schachner, M	J Biol Chem	2001