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ENPP1 [plasma membrane]
Stable Identifier
R-HSA-196973
Type
Protein [EntityWithAccessionedSequence]
Species
Homo sapiens
Compartment
plasma membrane
Synonyms
Ectonucleotide pyrophosphatase/phosphodiesterase 1, NPP1_HUMAN
Locations in the PathwayBrowser
Expand all
Metabolism (Homo sapiens)
Metabolism of vitamins and cofactors (Homo sapiens)
Metabolism of water-soluble vitamins and cofactors (Homo sapiens)
Vitamin B2 (riboflavin) metabolism (Homo sapiens)
2xENPP1 hydrolyzes FAD to FMN (Homo sapiens)
2xENPP1 [plasma membrane] (Homo sapiens)
ENPP1 [plasma membrane] (Homo sapiens)
Vitamin B5 (pantothenate) metabolism (Homo sapiens)
ENPPs hydrolyse CoA-SH to PPANT, PAP (Homo sapiens)
2xENPP1, 2xENPP2, 2xENPP3 [plasma membrane] (Homo sapiens)
2xENPP1 [plasma membrane] (Homo sapiens)
ENPP1 [plasma membrane] (Homo sapiens)
External Reference Information
External Reference
UniProt:P22413 ENPP1
Gene Names
ENPP1, M6S1, NPPS, PC1, PDNP1
Chain
chain:1-925, chain:103-925
Reference Genes
BioGPS Gene:5167 ENPP1
COSMIC (genes):ENPP1 ENPP1
CTD Gene:5167 ENPP1
dbSNP Gene:5167 ENPP1
ENSEMBL:ENSG00000197594 ENPP1
HGNC:3356 ENPP1
Monarch:5167 ENPP1
NCBI Gene:5167 ENPP1
OMIM:173335 ENPP1
UCSC:P22413 ENPP1
Reference Transcript
RefSeq:NM_006208.2 ENPP1
Other Identifiers
11726354_at
11726355_at
11726356_at
17012632
205065_PM_at
205065_at
205066_PM_s_at
205066_s_at
228952_PM_at
228952_at
229088_PM_at
229088_at
2925954
2925955
2925956
2925957
2925958
2925961
2925962
2925963
2925964
2925965
2925966
2925967
2925968
2925969
2925970
2925971
2925972
2925973
2925975
2925976
2925977
2925978
2925979
2925981
2925982
2925983
2925984
2925985
2925986
2925987
2925988
2925989
2925990
2925993
2925994
2925995
2925996
2925997
2925998
2925999
2926000
2926012
2926014
2926016
2926018
342_at
343_s_at
43085_at
50060_at
5167
53571_at
71432_at
8122099
A_14_P112066
A_23_P156880
A_32_P192376
D12485_at
GE57052
GO:0002376
GO:0003676
GO:0003824
GO:0004115
GO:0004527
GO:0004528
GO:0004551
GO:0005044
GO:0005158
GO:0005509
GO:0005515
GO:0005524
GO:0005576
GO:0005615
GO:0005765
GO:0005886
GO:0006091
GO:0006355
GO:0006790
GO:0006796
GO:0006955
GO:0008270
GO:0009143
GO:0009986
GO:0010467
GO:0016020
GO:0016192
GO:0016323
GO:0016787
GO:0016788
GO:0016791
GO:0030154
GO:0030247
GO:0030282
GO:0030308
GO:0030318
GO:0030500
GO:0030502
GO:0030505
GO:0030643
GO:0030730
GO:0031214
GO:0031953
GO:0032869
GO:0033198
GO:0036219
GO:0036221
GO:0038024
GO:0042803
GO:0045599
GO:0045719
GO:0046034
GO:0046325
GO:0046627
GO:0046872
GO:0047429
GO:0047693
GO:0048856
GO:0050427
GO:0050656
GO:0055062
GO:0055086
GO:0090304
GO:0106177
GO:1901135
GO:1990787
HMNXSV003005299
Hs.11951.0.S2_3p_at
Hs.25557.0.A1_3p_at
Hs.25557.0.A1_3p_x_at
Hs.44238.0.A1_3p_at
ILMN_1700888
PH_hs_0023099
TC06000985.hg
g13324676_3p_s_at
Participates
as a component of
2xENPP1 [plasma membrane] (Homo sapiens)
Inferred To
NPP1 [plasma membrane]
(Saccharomyces cerevisiae)
enpp1 [plasma membrane]
(Danio rerio)
enpp1 [plasma membrane]
(Xenopus tropicalis)
ENPP1 [plasma membrane]
(Bos taurus)
ENPP1 [plasma membrane]
(Caenorhabditis elegans)
ENPP1 [plasma membrane]
(Canis familiaris)
ENPP1 [plasma membrane]
(Dictyostelium discoideum)
ENPP1 [plasma membrane]
(Mus musculus)
ENPP1 [plasma membrane]
(Rattus norvegicus)
ENPP1 [plasma membrane]
(Schizosaccharomyces pombe)
ENPP1 [plasma membrane]
(Sus scrofa)
Homologues of ENPP1 [plasma membrane]
(Caenorhabditis elegans)
Homologues of ENPP1 [plasma membrane]
(Saccharomyces cerevisiae)
NPP2 [plasma membrane]
(Saccharomyces cerevisiae)
Cross References
ENSEMBL
ENST00000647893
,
ENSP00000498074
OpenTargets
ENSG00000197594
ZINC - Substances
ENPP1_HUMAN
ZINC target
P22413
PRO
P22413
GlyGen
P22413
PDB
2YS0
,
6WFJ
,
8GHR
,
6WEW
,
6WEV
,
6WET
,
6WEU
IntEnz
3.1.4.1
HPA
ENSG00000197594-ENPP1
Pharos - Targets
P22413
Orphanet
ENPP1
ZINC - Predictions - Purchasable
ENPP1_HUMAN
HMDB Protein
HMDBP00119
Interactors (2)
Accession
#Entities
Entities
Confidence Score
Evidence (IntAct)
UniProt:Q9UNQ0 ABCG2
2
HC-ABCG2 [plasma membrane]
(R-HSA-917929)
HC-ABCG2 [apical plasma membrane]
(R-HSA-9794401)
0.602
4
UniProt:Q9HB96 FANCE
2
FANCE [cytosol]
(R-HSA-420786)
FANCE [nucleoplasm]
(R-HSA-419543)
0.527
2
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