COASY phosphorylates DP-CoA

Stable Identifier
R-HSA-196773
Type
Reaction [transition]
Species
Homo sapiens
Compartment
Synonyms
Phosphorylation of dephospho-CoA to produce CoA
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The kinase activity of CoA synthase (COASY) catalyzes the phosphorylation of dephospho-CoA to form Coenzyme A (CoA-SH). The enzyme is located in the mitochondrial outer membrane (Daugherty et al. 2002; Zhyvoloup et al. 2003).

Literature References
PubMed ID Title Journal Year
11994049 Identification and characterization of the gene encoding the human phosphopantetheine adenylyltransferase and dephospho-CoA kinase bifunctional enzyme (CoA synthase)

Aghajanian, S, Worrall, DM

Biochem J 2002
14514684 Subcellular localization and regulation of coenzyme A synthase

Zhyvoloup, A, Nemazanyy, I, Panasyuk, G, Valovka, T, Fenton, T, Rebholz, H, Wang, ML, Foxon, R, Lyzogubov, V, Usenko, V, Kyyamova, R, Gorbenko, O, Matsuka, G, Filonenko, V, Gout, IT

J Biol Chem 2003
Participants
Participant Of
Catalyst Activity
Catalyst Activity
Title
dephospho-CoA kinase activity of COASY [mitochondrial outer membrane]
Physical Entity
Activity
Orthologous Events
Cross References
Rhea
Authored
Created
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