STING binds TRIM32 or TRIM56

Stable Identifier
R-HSA-1964496
Type
Reaction [binding]
Species
Homo sapiens
Compartment
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Tripartite motif (TRIM) family member TRIM56 was shown to interact with STING upon DNA stimulation promoting lysine 63-linked ubiquitination of STING and type I IFN induction (Tsuchida T et al. 2010). Another member of the family TRIM32 has also been implicated in K63-linked ubiquitination of STING (Zhang J et al. 2012).

Literature References
PubMed ID Title Journal Year
22745133 TRIM32 protein modulates type I interferon induction and cellular antiviral response by targeting MITA/STING protein for K63-linked ubiquitination

Zhang, J, Hu, MM, Wang, YY, Shu, HB

J. Biol. Chem. 2012
21074459 The ubiquitin ligase TRIM56 regulates innate immune responses to intracellular double-stranded DNA

Tsuchida, T, Zou, J, Saitoh, T, Kumar, H, Abe, T, Matsuura, Y, Kawai, T, Akira, S

Immunity 2010
Participants
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Orthologous Events
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Created