Reactome | Reduction of desmosterol to cholesterol

Reduction of desmosterol to cholesterol

Stable Identifier

R-HSA-196417

Type

Reaction [transition]

Species

Homo sapiens

Compartment

cytosol, endoplasmic reticulum membrane

Synonyms

desmosterol + NADPH + H(+) => cholesterol + NADP(+)

ReviewStatus

5/5

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Desmosterol is reduced by NADPH + H+ to form cholesterol and NADP+, catalyzed by DHCR24 associated with the endoplasmic reticulum membrane.

Literature References

PubMed ID	Title	Journal	Year
11519011	Mutations in the 3beta-hydroxysterol Delta24-reductase gene cause desmosterolosis, an autosomal recessive disorder of cholesterol biosynthesis Waterham, HR, Koster, J, Romeijn, GJ, Hennekam, RC, Vreken, P, Andersson, HC, FitzPatrick, DR, Kelley, RI	Am J Hum Genet	2001