Reactome | Reduction of desmosterol to cholesterol

Reduction of desmosterol to cholesterol

Stable Identifier

R-HSA-196417

Type

Reaction [transition]

Species

Homo sapiens

Compartment

cytosol, endoplasmic reticulum membrane

Synonyms

desmosterol + NADPH + H+ => cholesterol + NADP+

ReviewStatus

5/5

Locations in the PathwayBrowser

Expand all

General

SBML | | PDF

SVG | | PPTX | SBGN

Click the image above or here to open this reaction in the Pathway Browser
The layout of this reaction may differ from that in the pathway view due to the constraints in pathway layout

Desmosterol is reduced by NADPH + H+ to form cholesterol and NADP+, catalyzed by DHCR24 associated with the endoplasmic reticulum membrane.

Literature References

PubMed ID	Title	Journal	Year
11519011	Mutations in the 3beta-hydroxysterol Delta24-reductase gene cause desmosterolosis, an autosomal recessive disorder of cholesterol biosynthesis Vreken, P, Romeijn, GJ, FitzPatrick, DR, Hennekam, RC, Koster, J, Andersson, HC, Kelley, RI, Waterham, HR	Am J Hum Genet	2001